Enfermedad de Paget en Chile: una serie de 15 pacientes

Background: Paget disease of bone (PD) is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and m...

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Autores principales:	González V,Gilberto, Brusco G,Francisca, Arteaga U,Eugenio, Rodríguez P,José, Jacobelli G,Sergio, Massardo V,Loreto, Ortiz M,Cristián, Contreras O,Oscar
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Alkaline phosphatase Osteitis deformans Paget disease, extramammary
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000500003
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spelling	oai:scielo:S0034-988720030005000032004-12-13Enfermedad de Paget en Chile: una serie de 15 pacientesGonzález V,GilbertoBrusco G,FranciscaArteaga U,EugenioRodríguez P,JoséJacobelli G,SergioMassardo V,LoretoOrtiz M,CristiánContreras O,Oscar Alkaline phosphatase Osteitis deformans Paget disease, extramammary Background: Paget disease of bone (PD) is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and methods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian), eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit). Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.5 20032003-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000500003es10.4067/S0034-98872003000500003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alkaline phosphatase Osteitis deformans Paget disease, extramammary
spellingShingle	Alkaline phosphatase Osteitis deformans Paget disease, extramammary González V,Gilberto Brusco G,Francisca Arteaga U,Eugenio Rodríguez P,José Jacobelli G,Sergio Massardo V,Loreto Ortiz M,Cristián Contreras O,Oscar Enfermedad de Paget en Chile: una serie de 15 pacientes
description	Background: Paget disease of bone (PD) is a localized disorder of bone remodeling, which leads to bone fragility and deformity. In Chile PD is uncommon. Aim: To study clinical and demographic characteristics of patients with PD seen in the Clinical Hospital of the Catholic University. Patients and methods: Patients with typical radiological and clinical features of PD referred to our institution during the last decade were included in this review. Results: We obtained data from 15 patients with PD (ten males, eight Chilean, six European and one Asian), eleven of them were diagnosed during the last 3 years. The mean age at diagnosis was 68,7±11,1 years old. No one had first degree relatives with PD. Bone pain was the main complaint in 13 patients and elevated total alkaline phosphatases in the other two. The average duration of the symptoms prior to diagnosis was 38,8 months. Eight patients had monostotic lesions; the most commonly involved sites were the pelvis, spine and femur. Radiological evaluation disclosed sclerotic changes in all patients as well as bone deformity and osteoarthritis in eight patients. Total alkaline phosphatases were elevated in 14 cases (mean: 4 times over the upper normal limit). Conclusions: When compared to series of the Northern hemisphere, PD in Chile is characterized by an older age at diagnosis, a higher frequency of symptomatic presentation, advanced radiological involvement and greater proportion of complications. PD should be suspected in every patient, Chilean or foreigner, with bone pain or elevated alkaline phosphatases (Rev Méd Chile 2003; 131: 491-7).
author	González V,Gilberto Brusco G,Francisca Arteaga U,Eugenio Rodríguez P,José Jacobelli G,Sergio Massardo V,Loreto Ortiz M,Cristián Contreras O,Oscar
author_facet	González V,Gilberto Brusco G,Francisca Arteaga U,Eugenio Rodríguez P,José Jacobelli G,Sergio Massardo V,Loreto Ortiz M,Cristián Contreras O,Oscar
author_sort	González V,Gilberto
title	Enfermedad de Paget en Chile: una serie de 15 pacientes
title_short	Enfermedad de Paget en Chile: una serie de 15 pacientes
title_full	Enfermedad de Paget en Chile: una serie de 15 pacientes
title_fullStr	Enfermedad de Paget en Chile: una serie de 15 pacientes
title_full_unstemmed	Enfermedad de Paget en Chile: una serie de 15 pacientes
title_sort	enfermedad de paget en chile: una serie de 15 pacientes
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000500003
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Enfermedad de Paget en Chile: una serie de 15 pacientes

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