Efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemia
Background: Inulin is a non absorbable polysaccharide with prebiotic effects, whose influence on blood lipids or insulin sensitivity is not well known. Aim: To assess the effect of oral administration of inulin on lipid profile and insulin sensitivity in dyslipidemic obese subjects. Material and Met...
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Sociedad Médica de Santiago
2003
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oai:scielo:S0034-988720030006000022004-12-13Efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemiaBalcázar-Muñoz,Blanca RMartínez-Abundis,EsperanzaGonzález-Ortiz,Manuel Hyperlipidemia Insulin resistance Inulin Obesity Background: Inulin is a non absorbable polysaccharide with prebiotic effects, whose influence on blood lipids or insulin sensitivity is not well known. Aim: To assess the effect of oral administration of inulin on lipid profile and insulin sensitivity in dyslipidemic obese subjects. Material and Methods: A clinical trial, double blind, randomized with placebo was carried out in 12 obese, hypertrygliceridemic and hypercholesterolemic subjects between 19 and 32 years old. The subjects were randomized to receive 7 g/day of inulin or placebo in the morning, during 4 weeks. Biochemical and metabolic profiles and euglycemic-hyperinsulinemic clamp technique for assessing insulin sensitivity, before and after pharmacological intervention were performed. Results: After inulin administration, there was a significant reduction of total cholesterol (248.7±30.5 and 194.3±39.8 mg/dL; p=0.028), low density lipoprotein (LDL), cholesterol (136.0±27.8 and 113.0±36.2 mg/dL; p= 0.028), very low density lipoproteins (VLDL) (45.9±18.5 and 31.6±7.2 mg/dL; p=0.046) and trygliceride concentrations (235.5±85.9 and 171.1±37.9 mg/dL; p=0.046). No effect of inulin on insulin sensitivity was observed. Conclusions: The oral inulin administration reduced total cholesterol, LDL cholesterol, VLDL and trygliceride levels in dyslipidemic and obese subjects, without modifications in the insulin sensitivity. (Rev Méd Chile 2003; 131: 597-604)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.6 20032003-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000600002es10.4067/S0034-98872003000600002 |
institution |
Scielo Chile |
collection |
Scielo Chile |
language |
Spanish / Castilian |
topic |
Hyperlipidemia Insulin resistance Inulin Obesity |
spellingShingle |
Hyperlipidemia Insulin resistance Inulin Obesity Balcázar-Muñoz,Blanca R Martínez-Abundis,Esperanza González-Ortiz,Manuel Efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemia |
description |
Background: Inulin is a non absorbable polysaccharide with prebiotic effects, whose influence on blood lipids or insulin sensitivity is not well known. Aim: To assess the effect of oral administration of inulin on lipid profile and insulin sensitivity in dyslipidemic obese subjects. Material and Methods: A clinical trial, double blind, randomized with placebo was carried out in 12 obese, hypertrygliceridemic and hypercholesterolemic subjects between 19 and 32 years old. The subjects were randomized to receive 7 g/day of inulin or placebo in the morning, during 4 weeks. Biochemical and metabolic profiles and euglycemic-hyperinsulinemic clamp technique for assessing insulin sensitivity, before and after pharmacological intervention were performed. Results: After inulin administration, there was a significant reduction of total cholesterol (248.7±30.5 and 194.3±39.8 mg/dL; p=0.028), low density lipoprotein (LDL), cholesterol (136.0±27.8 and 113.0±36.2 mg/dL; p= 0.028), very low density lipoproteins (VLDL) (45.9±18.5 and 31.6±7.2 mg/dL; p=0.046) and trygliceride concentrations (235.5±85.9 and 171.1±37.9 mg/dL; p=0.046). No effect of inulin on insulin sensitivity was observed. Conclusions: The oral inulin administration reduced total cholesterol, LDL cholesterol, VLDL and trygliceride levels in dyslipidemic and obese subjects, without modifications in the insulin sensitivity. (Rev Méd Chile 2003; 131: 597-604) |
author |
Balcázar-Muñoz,Blanca R Martínez-Abundis,Esperanza González-Ortiz,Manuel |
author_facet |
Balcázar-Muñoz,Blanca R Martínez-Abundis,Esperanza González-Ortiz,Manuel |
author_sort |
Balcázar-Muñoz,Blanca R |
title |
Efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemia |
title_short |
Efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemia |
title_full |
Efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemia |
title_fullStr |
Efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemia |
title_full_unstemmed |
Efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemia |
title_sort |
efecto de la administración oral de inulina sobre el perfil de lípidos y la sensibilidad a la insulina en individuos con obesidad y dislipidemia |
publisher |
Sociedad Médica de Santiago |
publishDate |
2003 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000600002 |
work_keys_str_mv |
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