Efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónica

Background: The six minute walk test (6MW) elicits dynamic hyperinflation (DH) in severe COPD patients, which can be evaluated by reductions in inspiratory capacity (IC). Although IC is currently used to determine the effects of bronchodilators on DH during exercise tests on a cycle ergometer, its u...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jorquera A,Jorge, Díaz P,Orlando, Lisboa B,Carmen
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Ipratropium Lung diseases obstructive Spirometry
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000600003
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872003000600003
record_format	dspace
spelling	oai:scielo:S0034-988720030006000032004-12-13Efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónicaJorquera A,JorgeDíaz P,OrlandoLisboa B,Carmen Ipratropium Lung diseases obstructive Spirometry Background: The six minute walk test (6MW) elicits dynamic hyperinflation (DH) in severe COPD patients, which can be evaluated by reductions in inspiratory capacity (IC). Although IC is currently used to determine the effects of bronchodilators on DH during exercise tests on a cycle ergometer, its usefulness during a walking test has not been evaluated. Aim: To study the acute effects of ipratropium bromide (IB) on forced expiratory volume at l second (FEV1) and IC at rest and on DH during exercise assessed by the 6MW. Subjects and methods: Fifteen stable COPD patients were randomly allocated in a double-blind, placebo-controlled, crossover fashion to 2 treatment periods using a single dose of nebulized IB 500 mg or placebo. Spirometry, including IC, and 6MW were measured at baseline and after IB and placebo. IC was also measured 15 min after exercise. Dyspnea, oxygen saturation (SpO2) and heart rate were assessed at the end of exercise. Results: After IB, 8/15 patients exhibited a clinically significant increase in IC (<FONT FACE=Symbol>³1</FONT>0% predicted). A similar increase in FEV1 was observed in only one patient. No changes were observed with placebo. A significant increase in 6MW from baseline (p=0.007) was found after IB (45±14 m) compared to placebo (0.5±9 m), whereas dyspnea was significantly lower. Inspiratory capacity fell after 6MW with both treatments, but it reached their baseline values at 15 min after exercise only with IB. Conclusions: Our results demonstrate that IC provides additional information to conventional spirometry on the acute effects of bronchodilators and confirm its value to assess DH during a walking test (Rev Méd Chile 2003; 131: 605-612)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.6 20032003-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000600003es10.4067/S0034-98872003000600003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Ipratropium Lung diseases obstructive Spirometry
spellingShingle	Ipratropium Lung diseases obstructive Spirometry Jorquera A,Jorge Díaz P,Orlando Lisboa B,Carmen Efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónica
description	Background: The six minute walk test (6MW) elicits dynamic hyperinflation (DH) in severe COPD patients, which can be evaluated by reductions in inspiratory capacity (IC). Although IC is currently used to determine the effects of bronchodilators on DH during exercise tests on a cycle ergometer, its usefulness during a walking test has not been evaluated. Aim: To study the acute effects of ipratropium bromide (IB) on forced expiratory volume at l second (FEV1) and IC at rest and on DH during exercise assessed by the 6MW. Subjects and methods: Fifteen stable COPD patients were randomly allocated in a double-blind, placebo-controlled, crossover fashion to 2 treatment periods using a single dose of nebulized IB 500 mg or placebo. Spirometry, including IC, and 6MW were measured at baseline and after IB and placebo. IC was also measured 15 min after exercise. Dyspnea, oxygen saturation (SpO2) and heart rate were assessed at the end of exercise. Results: After IB, 8/15 patients exhibited a clinically significant increase in IC (<FONT FACE=Symbol>³1</FONT>0% predicted). A similar increase in FEV1 was observed in only one patient. No changes were observed with placebo. A significant increase in 6MW from baseline (p=0.007) was found after IB (45±14 m) compared to placebo (0.5±9 m), whereas dyspnea was significantly lower. Inspiratory capacity fell after 6MW with both treatments, but it reached their baseline values at 15 min after exercise only with IB. Conclusions: Our results demonstrate that IC provides additional information to conventional spirometry on the acute effects of bronchodilators and confirm its value to assess DH during a walking test (Rev Méd Chile 2003; 131: 605-612)
author	Jorquera A,Jorge Díaz P,Orlando Lisboa B,Carmen
author_facet	Jorquera A,Jorge Díaz P,Orlando Lisboa B,Carmen
author_sort	Jorquera A,Jorge
title	Efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónica
title_short	Efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónica
title_full	Efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónica
title_fullStr	Efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónica
title_full_unstemmed	Efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónica
title_sort	efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónica
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000600003
work_keys_str_mv	AT jorqueraajorge efectodelbromurodeipratropiosobrelahiperinflacionpulmonardinamicaenpacientesconenfermedadpulmonarobstructivacronica AT diazporlando efectodelbromurodeipratropiosobrelahiperinflacionpulmonardinamicaenpacientesconenfermedadpulmonarobstructivacronica AT lisboabcarmen efectodelbromurodeipratropiosobrelahiperinflacionpulmonardinamicaenpacientesconenfermedadpulmonarobstructivacronica
_version_	1718436095617662976

Efecto del bromuro de ipratropio sobre la hiperinflación pulmonar dinámica en pacientes con enfermedad pulmonar obstructiva crónica

Ejemplares similares