Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca

Background : Environmental and genetic factors (viruses, toxins and diet) are involved in the aetiology of type 1 diabetes. Among the dietary factors, the role of breast feeding and exposure to cow's milk proteins deserve special attention. Aim: To determine the anti-BSA-IgG levels in type 1 di...

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Autores principales:	Oyarzún A,Amaya, Santos M,J Luis, Carrasco P,Elena, Albala B,Cecilia, Salinas T,Alfonso, Pérez B,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Breast feeding Diabetes Mellitus insulin-dependent Insulin antibodies Milk proteins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000800005
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spelling	oai:scielo:S0034-988720030008000052004-12-13Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vacaOyarzún A,AmayaSantos M,J LuisCarrasco P,ElenaAlbala B,CeciliaSalinas T,AlfonsoPérez B,Francisco Breast feeding Diabetes Mellitus insulin-dependent Insulin antibodies Milk proteins Background : Environmental and genetic factors (viruses, toxins and diet) are involved in the aetiology of type 1 diabetes. Among the dietary factors, the role of breast feeding and exposure to cow's milk proteins deserve special attention. Aim: To determine the anti-BSA-IgG levels in type 1 diabetic children and to analyse the possible association with breast feeding duration, exposure to cow's milk and ß pancreatic auto-antibodies. Patients and methods: Blood samples were collected from 161 diabetic children and 144 controls to measure anti-BSA-IgG level, GAD65, IA-2 and ICA autoantibodies. All children answered a questionnaire about dietary habits during infancy. Results: anti-BSA-IgG was positive (using a cut off point of 25.6 ng/ml) in 98% of diabetic children and 0% of the control population. The length of breast feeding or early exposure to cow's milk did not influence the concentration of anti-BSA-IgG. Positive BSA titers did not increase the ß pancreatic reactivity (ICA+, GAD+, IA-2+). Conclusions: Our data confirm the high frequency of anti-BSA-IgG among diabetic children. However, a specific role in the immunological process of type 1 diabetes cannot be attributed to this protein (Rev Méd Chile 2003; 131: 865-72)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.8 20032003-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000800005es10.4067/S0034-98872003000800005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Breast feeding Diabetes Mellitus insulin-dependent Insulin antibodies Milk proteins
spellingShingle	Breast feeding Diabetes Mellitus insulin-dependent Insulin antibodies Milk proteins Oyarzún A,Amaya Santos M,J Luis Carrasco P,Elena Albala B,Cecilia Salinas T,Alfonso Pérez B,Francisco Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca
description	Background : Environmental and genetic factors (viruses, toxins and diet) are involved in the aetiology of type 1 diabetes. Among the dietary factors, the role of breast feeding and exposure to cow's milk proteins deserve special attention. Aim: To determine the anti-BSA-IgG levels in type 1 diabetic children and to analyse the possible association with breast feeding duration, exposure to cow's milk and ß pancreatic auto-antibodies. Patients and methods: Blood samples were collected from 161 diabetic children and 144 controls to measure anti-BSA-IgG level, GAD65, IA-2 and ICA autoantibodies. All children answered a questionnaire about dietary habits during infancy. Results: anti-BSA-IgG was positive (using a cut off point of 25.6 ng/ml) in 98% of diabetic children and 0% of the control population. The length of breast feeding or early exposure to cow's milk did not influence the concentration of anti-BSA-IgG. Positive BSA titers did not increase the ß pancreatic reactivity (ICA+, GAD+, IA-2+). Conclusions: Our data confirm the high frequency of anti-BSA-IgG among diabetic children. However, a specific role in the immunological process of type 1 diabetes cannot be attributed to this protein (Rev Méd Chile 2003; 131: 865-72)
author	Oyarzún A,Amaya Santos M,J Luis Carrasco P,Elena Albala B,Cecilia Salinas T,Alfonso Pérez B,Francisco
author_facet	Oyarzún A,Amaya Santos M,J Luis Carrasco P,Elena Albala B,Cecilia Salinas T,Alfonso Pérez B,Francisco
author_sort	Oyarzún A,Amaya
title	Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca
title_short	Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca
title_full	Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca
title_fullStr	Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca
title_full_unstemmed	Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca
title_sort	anticuerpos anti-albúmina bovina (bsa) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000800005
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Anticuerpos anti-albúmina bovina (BSA) en niños diabéticos tipo 1 recién diagnosticados y su asociación con lactancia materna y exposición a leche de vaca

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