Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular

Hyperhomocysteinemia is an independent cardiovascular risk factor that depends on folate and vitamin B12 nutrition. Aim: To measure homocysteine, folic acid and vitamin B12 serum levels in healthy children with and without a family history of cardiovascular disease. Subjects and methods: Forty child...

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Autores principales:	Casanueva E,Víctor, Cid C,Ximena, Cancino M,Matilde, Borzone T,Laura, Cid S,Luis
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Cardiovascular diseases Folic acid Homocysteine Risk factors Vitamin B12
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000900005
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spelling	oai:scielo:S0034-988720030009000052004-12-13Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascularCasanueva E,VíctorCid C,XimenaCancino M,MatildeBorzone T,LauraCid S,Luis Cardiovascular diseases Folic acid Homocysteine Risk factors Vitamin B12 Hyperhomocysteinemia is an independent cardiovascular risk factor that depends on folate and vitamin B12 nutrition. Aim: To measure homocysteine, folic acid and vitamin B12 serum levels in healthy children with and without a family history of cardiovascular disease. Subjects and methods: Forty children aged 6 to 15 years with a family history of cardiovascular disease, and 40 age and sex matched children without such history were studied. Serum homocysteine, folic acid and vitamin B12 were measured in a fasting blood sample. Homocysteine was measured by a fluorescence polarization immunoassay (FPIA), vitamin B12 by enzymatic microparticle assay, covered with intrinsic factor and folic acid by ionic capture, using commercial kits. Results: Children with family history of cardiovascular disease had higher homocysteine levels than their counterparts without family history (7.9±3 and 5.8±2 µmol/l respectively, p <0.03), but similar folic acid (5.2±1.8 and 5.5±1.4 pg/ml respectively) and vitamin B12 levels (431±213 and 445±209 ng/ml respectively). There was a negative and significant correlation between homocysteine and folic acid and vitamin B12 levels. Conclusions: Children with a family history of cardiovascular disease have higher levels of serum homocysteine than those without such history, despite having similar levels of folic acid and vitamin B12info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.9 20032003-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000900005es10.4067/S0034-98872003000900005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cardiovascular diseases Folic acid Homocysteine Risk factors Vitamin B12
spellingShingle	Cardiovascular diseases Folic acid Homocysteine Risk factors Vitamin B12 Casanueva E,Víctor Cid C,Ximena Cancino M,Matilde Borzone T,Laura Cid S,Luis Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular
description	Hyperhomocysteinemia is an independent cardiovascular risk factor that depends on folate and vitamin B12 nutrition. Aim: To measure homocysteine, folic acid and vitamin B12 serum levels in healthy children with and without a family history of cardiovascular disease. Subjects and methods: Forty children aged 6 to 15 years with a family history of cardiovascular disease, and 40 age and sex matched children without such history were studied. Serum homocysteine, folic acid and vitamin B12 were measured in a fasting blood sample. Homocysteine was measured by a fluorescence polarization immunoassay (FPIA), vitamin B12 by enzymatic microparticle assay, covered with intrinsic factor and folic acid by ionic capture, using commercial kits. Results: Children with family history of cardiovascular disease had higher homocysteine levels than their counterparts without family history (7.9±3 and 5.8±2 µmol/l respectively, p <0.03), but similar folic acid (5.2±1.8 and 5.5±1.4 pg/ml respectively) and vitamin B12 levels (431±213 and 445±209 ng/ml respectively). There was a negative and significant correlation between homocysteine and folic acid and vitamin B12 levels. Conclusions: Children with a family history of cardiovascular disease have higher levels of serum homocysteine than those without such history, despite having similar levels of folic acid and vitamin B12
author	Casanueva E,Víctor Cid C,Ximena Cancino M,Matilde Borzone T,Laura Cid S,Luis
author_facet	Casanueva E,Víctor Cid C,Ximena Cancino M,Matilde Borzone T,Laura Cid S,Luis
author_sort	Casanueva E,Víctor
title	Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular
title_short	Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular
title_full	Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular
title_fullStr	Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular
title_full_unstemmed	Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular
title_sort	homocisteína en niños y adolescentes. relación con historia familiar de enfermedad cardiovascular
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000900005
work_keys_str_mv	AT casanuevaevictor homocisteinaenninosyadolescentesrelacionconhistoriafamiliardeenfermedadcardiovascular AT cidcximena homocisteinaenninosyadolescentesrelacionconhistoriafamiliardeenfermedadcardiovascular AT cancinommatilde homocisteinaenninosyadolescentesrelacionconhistoriafamiliardeenfermedadcardiovascular AT borzonetlaura homocisteinaenninosyadolescentesrelacionconhistoriafamiliardeenfermedadcardiovascular AT cidsluis homocisteinaenninosyadolescentesrelacionconhistoriafamiliardeenfermedadcardiovascular
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Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular

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