Transmisión familiar del virus de la hepatitis C en un grupo de población chilena

Intravenous drug use, sexual promiscuity and a longer cohabitation period are considered risk factors for familial transmission of hepatitis C virus. The relative importance of this type of transmission is a subject of controversy. Aim: To study familial clustering of hepatitis C virus infection and...

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Autores principales:	Velasco R,Marta, Poniachik T,Jaime, Alegría Q,Silvia, Brahm B,Javier
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Antibodies viral Family health Hepatitis C antibodies
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003001000004
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spelling	oai:scielo:S0034-988720030010000042004-12-07Transmisión familiar del virus de la hepatitis C en un grupo de población chilenaVelasco R,MartaPoniachik T,JaimeAlegría Q,SilviaBrahm B,Javier Antibodies viral Family health Hepatitis C antibodies Intravenous drug use, sexual promiscuity and a longer cohabitation period are considered risk factors for familial transmission of hepatitis C virus. The relative importance of this type of transmission is a subject of controversy. Aim: To study familial clustering of hepatitis C virus infection and its risk factors. Material and methods: HCV positive patients (91 with chronic hepatitis, 88 with cirrhosis, nine with hepatic carcinoma and 29 hemophiliacs) were the index cases. HCV antibodies were measured by ELISA and the type of relationship with the index case was investigated in 317 family members. Results: Positive anti HVC antibodies were detected in 12 of 243 family members of patients with chronic liver disease and in none of the family members of patients with hemophilia. Of these, five were couples of an index case with a long cohabitation period. Ten members had an index case with a severe liver disease (three with Child C cirrhosis and seven with liver carcinoma). Conclusions: Family transmission of HCV infection is uncommon in Chile. The association of severe liver disease and family transmission could be due to a higher viral load as responsible for transmission during the early periods of a long lasting disease (Rev Méd Chile 2003; 131: 1123-27).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.10 20032003-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003001000004es10.4067/S0034-98872003001000004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antibodies viral Family health Hepatitis C antibodies
spellingShingle	Antibodies viral Family health Hepatitis C antibodies Velasco R,Marta Poniachik T,Jaime Alegría Q,Silvia Brahm B,Javier Transmisión familiar del virus de la hepatitis C en un grupo de población chilena
description	Intravenous drug use, sexual promiscuity and a longer cohabitation period are considered risk factors for familial transmission of hepatitis C virus. The relative importance of this type of transmission is a subject of controversy. Aim: To study familial clustering of hepatitis C virus infection and its risk factors. Material and methods: HCV positive patients (91 with chronic hepatitis, 88 with cirrhosis, nine with hepatic carcinoma and 29 hemophiliacs) were the index cases. HCV antibodies were measured by ELISA and the type of relationship with the index case was investigated in 317 family members. Results: Positive anti HVC antibodies were detected in 12 of 243 family members of patients with chronic liver disease and in none of the family members of patients with hemophilia. Of these, five were couples of an index case with a long cohabitation period. Ten members had an index case with a severe liver disease (three with Child C cirrhosis and seven with liver carcinoma). Conclusions: Family transmission of HCV infection is uncommon in Chile. The association of severe liver disease and family transmission could be due to a higher viral load as responsible for transmission during the early periods of a long lasting disease (Rev Méd Chile 2003; 131: 1123-27).
author	Velasco R,Marta Poniachik T,Jaime Alegría Q,Silvia Brahm B,Javier
author_facet	Velasco R,Marta Poniachik T,Jaime Alegría Q,Silvia Brahm B,Javier
author_sort	Velasco R,Marta
title	Transmisión familiar del virus de la hepatitis C en un grupo de población chilena
title_short	Transmisión familiar del virus de la hepatitis C en un grupo de población chilena
title_full	Transmisión familiar del virus de la hepatitis C en un grupo de población chilena
title_fullStr	Transmisión familiar del virus de la hepatitis C en un grupo de población chilena
title_full_unstemmed	Transmisión familiar del virus de la hepatitis C en un grupo de población chilena
title_sort	transmisión familiar del virus de la hepatitis c en un grupo de población chilena
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003001000004
work_keys_str_mv	AT velascormarta transmisionfamiliardelvirusdelahepatitiscenungrupodepoblacionchilena AT poniachiktjaime transmisionfamiliardelvirusdelahepatitiscenungrupodepoblacionchilena AT alegriaqsilvia transmisionfamiliardelvirusdelahepatitiscenungrupodepoblacionchilena AT brahmbjavier transmisionfamiliardelvirusdelahepatitiscenungrupodepoblacionchilena
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Transmisión familiar del virus de la hepatitis C en un grupo de población chilena

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