Daño hepático por fármacos: características clínicas e histológicas en 33 casos

Drug induced liver disease (DILD) is common and of difficult diagnosis. Aim: To report the clinical, laboratory and pathological findings in 33 patients with DILD. Patients and methods: We revised 1,164 liver biopsies and 57 were selected as suspicious of DILD. In these, the scale proposed by Maria...

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Autores principales:	Contreras B,Jorge, Poniachik T,Jaime, Planzer D,Marcela, Lazarte C,Raúl, Smok S,Gladys, Oksenberg R,Danny, Madrid S,Ana María, Brahm B,Javier
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Drug hypersensitivity Drug toxicity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003001000005
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spelling	oai:scielo:S0034-988720030010000052004-12-07Daño hepático por fármacos: características clínicas e histológicas en 33 casosContreras B,JorgePoniachik T,JaimePlanzer D,MarcelaLazarte C,RaúlSmok S,GladysOksenberg R,DannyMadrid S,Ana MaríaBrahm B,Javier Drug hypersensitivity Drug toxicity Drug induced liver disease (DILD) is common and of difficult diagnosis. Aim: To report the clinical, laboratory and pathological findings in 33 patients with DILD. Patients and methods: We revised 1,164 liver biopsies and 57 were selected as suspicious of DILD. In these, the scale proposed by Maria et al was applied to assess the possibility of hepatotoxicity reactions and 33 were selected. Results: The 33 cases had a mean age of 48±18 years and 14 were male. Forty eight medications were involved, with an average of 1.4 drugs per patient. The main drugs were antimicrobials, antineoplastics-immunosuppresives and non-steroidal antiinflammatory drugs. The clinical presentations in order of frequency were cholestasis, hepatitis, asymptomatic, fulminant hepatitis and cirrhosis. The laboratory alterations observed in cases with hepatitis were 20 fold transaminase and bilirubin elevation. In cholestasis, moderate elevations of alkaline phosphatases and gamma glytamyl transferase were observed. Pathology showed hepatocellular damage, cholestasis and mixed damage, but also submassive necrosis and cirrhosis in one case. Conclusions: The present study confirms that DILD is frequently unpredictable and that it can cause a wide variety of clinical and pathological presentations, that can even evolve to chronicity (Rev Méd Chile 2003; 131: 1128-34).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.10 20032003-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003001000005es10.4067/S0034-98872003001000005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Drug hypersensitivity Drug toxicity
spellingShingle	Drug hypersensitivity Drug toxicity Contreras B,Jorge Poniachik T,Jaime Planzer D,Marcela Lazarte C,Raúl Smok S,Gladys Oksenberg R,Danny Madrid S,Ana María Brahm B,Javier Daño hepático por fármacos: características clínicas e histológicas en 33 casos
description	Drug induced liver disease (DILD) is common and of difficult diagnosis. Aim: To report the clinical, laboratory and pathological findings in 33 patients with DILD. Patients and methods: We revised 1,164 liver biopsies and 57 were selected as suspicious of DILD. In these, the scale proposed by Maria et al was applied to assess the possibility of hepatotoxicity reactions and 33 were selected. Results: The 33 cases had a mean age of 48±18 years and 14 were male. Forty eight medications were involved, with an average of 1.4 drugs per patient. The main drugs were antimicrobials, antineoplastics-immunosuppresives and non-steroidal antiinflammatory drugs. The clinical presentations in order of frequency were cholestasis, hepatitis, asymptomatic, fulminant hepatitis and cirrhosis. The laboratory alterations observed in cases with hepatitis were 20 fold transaminase and bilirubin elevation. In cholestasis, moderate elevations of alkaline phosphatases and gamma glytamyl transferase were observed. Pathology showed hepatocellular damage, cholestasis and mixed damage, but also submassive necrosis and cirrhosis in one case. Conclusions: The present study confirms that DILD is frequently unpredictable and that it can cause a wide variety of clinical and pathological presentations, that can even evolve to chronicity (Rev Méd Chile 2003; 131: 1128-34).
author	Contreras B,Jorge Poniachik T,Jaime Planzer D,Marcela Lazarte C,Raúl Smok S,Gladys Oksenberg R,Danny Madrid S,Ana María Brahm B,Javier
author_facet	Contreras B,Jorge Poniachik T,Jaime Planzer D,Marcela Lazarte C,Raúl Smok S,Gladys Oksenberg R,Danny Madrid S,Ana María Brahm B,Javier
author_sort	Contreras B,Jorge
title	Daño hepático por fármacos: características clínicas e histológicas en 33 casos
title_short	Daño hepático por fármacos: características clínicas e histológicas en 33 casos
title_full	Daño hepático por fármacos: características clínicas e histológicas en 33 casos
title_fullStr	Daño hepático por fármacos: características clínicas e histológicas en 33 casos
title_full_unstemmed	Daño hepático por fármacos: características clínicas e histológicas en 33 casos
title_sort	daño hepático por fármacos: características clínicas e histológicas en 33 casos
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003001000005
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Daño hepático por fármacos: características clínicas e histológicas en 33 casos

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