Ética científica de la terapia génica de individuos: Urgencia de la Cirugía Génica del ADN

Gene therapy for individuals is mainly directed to somatic or germ cells. The present technology aims to insert a DNA segment in the recipient cells. This therapy is useful in Mendelian recessive diseases. There is an ethical moratorium to perform insertion gene therapy in germ cells, because this p...

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Autor principal:	Valenzuela,Carlos Y
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2003
Materias:	Gene Therapy Gene surgery Genetic techniques Germ cells
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003001000018
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spelling	oai:scielo:S0034-988720030010000182004-12-07Ética científica de la terapia génica de individuos: Urgencia de la Cirugía Génica del ADNValenzuela,Carlos Y Gene Therapy Gene surgery Genetic techniques Germ cells Gene therapy for individuals is mainly directed to somatic or germ cells. The present technology aims to insert a DNA segment in the recipient cells. This therapy is useful in Mendelian recessive diseases. There is an ethical moratorium to perform insertion gene therapy in germ cells, because this procedure increases the human genome. Somatic cell gene therapy cures individuals but increases the gene frequency of genetic diseases in the population. This occurs because the descendants of the cured patient should carry his or her «ill» genes. We denote by «DNA gene surgery» the procedure that replaces «ill» nucleotide(s) by healthy one(s) conserving the genome size and the gene context of expression and regulation. Several procedures for gene surgery have been applied to cells and animals. Those based on DNA repair as Chimeric RNA/DNA, one stranded oligonucleotides and tristranded DNA. Those based on DNA recombination with oligo-DNA or one stranded DNA, and transposable DNA segments. Gene surgery can be applied to germ cell gene therapy without ethical contraindications. It can cure Mendelian dominant diseases and it can be applied to heterozygotes. It preserves the regulation and expression gene context. If a technical safe procedure is available, the entire mankind could be treated and cured of all the Mendelian diseases, in one generation. Susceptibilities for all diseases could also be treated. The moratorium for research on germ cell gene therapy by gene surgery should be interrupted. Safe gene surgery is a moral imperative for gene therapy of patients and their descendants, for the treatment of dominant genetic diseases and for heterozygous carriers of recessive disorders (Rev Méd Chile 2003; 131: 1208-14).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.131 n.10 20032003-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003001000018es10.4067/S0034-98872003001000018
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Gene Therapy Gene surgery Genetic techniques Germ cells
spellingShingle	Gene Therapy Gene surgery Genetic techniques Germ cells Valenzuela,Carlos Y Ética científica de la terapia génica de individuos: Urgencia de la Cirugía Génica del ADN
description	Gene therapy for individuals is mainly directed to somatic or germ cells. The present technology aims to insert a DNA segment in the recipient cells. This therapy is useful in Mendelian recessive diseases. There is an ethical moratorium to perform insertion gene therapy in germ cells, because this procedure increases the human genome. Somatic cell gene therapy cures individuals but increases the gene frequency of genetic diseases in the population. This occurs because the descendants of the cured patient should carry his or her «ill» genes. We denote by «DNA gene surgery» the procedure that replaces «ill» nucleotide(s) by healthy one(s) conserving the genome size and the gene context of expression and regulation. Several procedures for gene surgery have been applied to cells and animals. Those based on DNA repair as Chimeric RNA/DNA, one stranded oligonucleotides and tristranded DNA. Those based on DNA recombination with oligo-DNA or one stranded DNA, and transposable DNA segments. Gene surgery can be applied to germ cell gene therapy without ethical contraindications. It can cure Mendelian dominant diseases and it can be applied to heterozygotes. It preserves the regulation and expression gene context. If a technical safe procedure is available, the entire mankind could be treated and cured of all the Mendelian diseases, in one generation. Susceptibilities for all diseases could also be treated. The moratorium for research on germ cell gene therapy by gene surgery should be interrupted. Safe gene surgery is a moral imperative for gene therapy of patients and their descendants, for the treatment of dominant genetic diseases and for heterozygous carriers of recessive disorders (Rev Méd Chile 2003; 131: 1208-14).
author	Valenzuela,Carlos Y
author_facet	Valenzuela,Carlos Y
author_sort	Valenzuela,Carlos Y
title	Ética científica de la terapia génica de individuos: Urgencia de la Cirugía Génica del ADN
title_short	Ética científica de la terapia génica de individuos: Urgencia de la Cirugía Génica del ADN
title_full	Ética científica de la terapia génica de individuos: Urgencia de la Cirugía Génica del ADN
title_fullStr	Ética científica de la terapia génica de individuos: Urgencia de la Cirugía Génica del ADN
title_full_unstemmed	Ética científica de la terapia génica de individuos: Urgencia de la Cirugía Génica del ADN
title_sort	ética científica de la terapia génica de individuos: urgencia de la cirugía génica del adn
publisher	Sociedad Médica de Santiago
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872003001000018
work_keys_str_mv	AT valenzuelacarlosy eticacientificadelaterapiagenicadeindividuosurgenciadelacirugiagenicadeladn
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Ética científica de la terapia génica de individuos: Urgencia de la Cirugía Génica del ADN

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