Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar

Gallbladder cancer is generally associated with a poor prognosis, being local recurrence the main pattern of failure. Aim: To evaluate neoadjuvant chemoradiation as a means to improve the prognosis in gallbladder cancer. Patients and methods: Twenty three gallbladder cancer patients were prospective...

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Autores principales:	de Aretxabala U,Xabier, Losada M,Héctor, Mora P,Javier, Roa E,Iván, Burgos S,Luis, Yáñez R,Eduardo, Quijada P,Ingrid, Roa S,Juan Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Chemotherapy adjuvant Gallbladder neoplasms Radiotherapy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000100008
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spelling	oai:scielo:S0034-988720040001000082014-08-14Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliarde Aretxabala U,XabierLosada M,HéctorMora P,JavierRoa E,IvánBurgos S,LuisYáñez R,EduardoQuijada P,IngridRoa S,Juan Carlos Chemotherapy adjuvant Gallbladder neoplasms Radiotherapy adjuvant Gallbladder cancer is generally associated with a poor prognosis, being local recurrence the main pattern of failure. Aim: To evaluate neoadjuvant chemoradiation as a means to improve the prognosis in gallbladder cancer. Patients and methods: Twenty three gallbladder cancer patients were prospectively treated between June 1993 and September 1999 in the Temuco Regional Hospital. Eighteen (82%) patients had subserosal infiltration, while three (13%) had serosal and two (9%) adipose tissue infiltration. Chemotherapy was done with 5-fluorouracil in continuous infusion during 5 days at day 1 and 28 of treatment. Radiotherapy consisted in a total dose of 4500 cGy, divided in 25 sessions. Patients' survival was compared with a series of 19 patients not subjected to chemoradiation, formerly treated at the institution. Results: Twenty patients had hematological problems secondary to the therapy. Leucopenia and thrombocytopenia were the most common toxic effects and eight had leucopenia under 2.0 x 10³ during the treatment course. Chemoradiation delayed surgical treatment in eight patients. After the chemoradiation protocol, seven patients were excluded from surgical treatment and 14 patients underwent resection. Three of the latter (11%) had liver involvement and four (14%) had lymph node involvement. Among the patients who underwent resection, five are still alive with a follow up of 43.8 months. Treated patients had a worst actuarial survival than subjects not treated with chemoradiation. Conclusions: In this series of patients chemoradiation had no positive effect and a potentially detrimental effect in patients with gallbladder cancer (Rev Méd Chile 2004; 132: 51-7).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.1 20042004-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000100008es10.4067/S0034-98872004000100008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Chemotherapy adjuvant Gallbladder neoplasms Radiotherapy adjuvant
spellingShingle	Chemotherapy adjuvant Gallbladder neoplasms Radiotherapy adjuvant de Aretxabala U,Xabier Losada M,Héctor Mora P,Javier Roa E,Iván Burgos S,Luis Yáñez R,Eduardo Quijada P,Ingrid Roa S,Juan Carlos Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar
description	Gallbladder cancer is generally associated with a poor prognosis, being local recurrence the main pattern of failure. Aim: To evaluate neoadjuvant chemoradiation as a means to improve the prognosis in gallbladder cancer. Patients and methods: Twenty three gallbladder cancer patients were prospectively treated between June 1993 and September 1999 in the Temuco Regional Hospital. Eighteen (82%) patients had subserosal infiltration, while three (13%) had serosal and two (9%) adipose tissue infiltration. Chemotherapy was done with 5-fluorouracil in continuous infusion during 5 days at day 1 and 28 of treatment. Radiotherapy consisted in a total dose of 4500 cGy, divided in 25 sessions. Patients' survival was compared with a series of 19 patients not subjected to chemoradiation, formerly treated at the institution. Results: Twenty patients had hematological problems secondary to the therapy. Leucopenia and thrombocytopenia were the most common toxic effects and eight had leucopenia under 2.0 x 10³ during the treatment course. Chemoradiation delayed surgical treatment in eight patients. After the chemoradiation protocol, seven patients were excluded from surgical treatment and 14 patients underwent resection. Three of the latter (11%) had liver involvement and four (14%) had lymph node involvement. Among the patients who underwent resection, five are still alive with a follow up of 43.8 months. Treated patients had a worst actuarial survival than subjects not treated with chemoradiation. Conclusions: In this series of patients chemoradiation had no positive effect and a potentially detrimental effect in patients with gallbladder cancer (Rev Méd Chile 2004; 132: 51-7).
author	de Aretxabala U,Xabier Losada M,Héctor Mora P,Javier Roa E,Iván Burgos S,Luis Yáñez R,Eduardo Quijada P,Ingrid Roa S,Juan Carlos
author_facet	de Aretxabala U,Xabier Losada M,Héctor Mora P,Javier Roa E,Iván Burgos S,Luis Yáñez R,Eduardo Quijada P,Ingrid Roa S,Juan Carlos
author_sort	de Aretxabala U,Xabier
title	Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar
title_short	Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar
title_full	Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar
title_fullStr	Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar
title_full_unstemmed	Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar
title_sort	quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000100008
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Quimiorradioterapia de neoadyuvancia en cáncer de vesícula biliar

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