HBME-1 y ciclina D1: marcadores diagnósticos de carcinoma folicular del tiroides

Background: Follicular carcinomas account for 15% of thyroid malignant tumors. The differential diagnosis between adenoma and minimally invasive follicular carcinoma is difficult and lacks reproducibility especially in frozen sections. As the diagnosis depends on finding foci of capsular invasion, m...

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Autores principales:	Moyano S,Leonor, Franco T,Carmen, Carreño T,Laura, Robinson M,Patricia, Sánchez J,Gabriel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Cyclin D-1 Immunohistochemistry Thyroid neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300001
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spelling	oai:scielo:S0034-988720040003000012004-12-13HBME-1 y ciclina D1: marcadores diagnósticos de carcinoma folicular del tiroidesMoyano S,LeonorFranco T,CarmenCarreño T,LauraRobinson M,PatriciaSánchez J,Gabriel Cyclin D-1 Immunohistochemistry Thyroid neoplasms Background: Follicular carcinomas account for 15% of thyroid malignant tumors. The differential diagnosis between adenoma and minimally invasive follicular carcinoma is difficult and lacks reproducibility especially in frozen sections. As the diagnosis depends on finding foci of capsular invasion, multiple sections must be examined. Numerous immunohistochemical markers have been studied for determining malignancy. Aim: To assess the efficacy of HBME-1 and Cyclin-D1 as diagnostic markers for follicular thyroid carcinoma. Material and method: We evaluated retrospectively 21 thyroidectomy specimens of 18 women and 3 men with diagnosis of adenoma or follicular carcinomas, both by hematoxylin and eosin stain and by immunohistochemistry using the avidin biotin method for the markers HBME-1 and Cyclin D1. Results: The sensitivity and specificity of HBME-1 for the diagnosis of follicular thyroid carcinoma, were 88.9% and 100%, respectively whereas for Cyclin D1 the sensitivity and specificity were 22.2% and 100%, respectively. There were no false positive cases. Conclusions: HBME-1 has excellent sensitivity and specificity for the diagnosis of follicular carcinoma (Rev Méd Chile 2004; 132: 279-84).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.3 20042004-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300001es10.4067/S0034-98872004000300001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cyclin D-1 Immunohistochemistry Thyroid neoplasms
spellingShingle	Cyclin D-1 Immunohistochemistry Thyroid neoplasms Moyano S,Leonor Franco T,Carmen Carreño T,Laura Robinson M,Patricia Sánchez J,Gabriel HBME-1 y ciclina D1: marcadores diagnósticos de carcinoma folicular del tiroides
description	Background: Follicular carcinomas account for 15% of thyroid malignant tumors. The differential diagnosis between adenoma and minimally invasive follicular carcinoma is difficult and lacks reproducibility especially in frozen sections. As the diagnosis depends on finding foci of capsular invasion, multiple sections must be examined. Numerous immunohistochemical markers have been studied for determining malignancy. Aim: To assess the efficacy of HBME-1 and Cyclin-D1 as diagnostic markers for follicular thyroid carcinoma. Material and method: We evaluated retrospectively 21 thyroidectomy specimens of 18 women and 3 men with diagnosis of adenoma or follicular carcinomas, both by hematoxylin and eosin stain and by immunohistochemistry using the avidin biotin method for the markers HBME-1 and Cyclin D1. Results: The sensitivity and specificity of HBME-1 for the diagnosis of follicular thyroid carcinoma, were 88.9% and 100%, respectively whereas for Cyclin D1 the sensitivity and specificity were 22.2% and 100%, respectively. There were no false positive cases. Conclusions: HBME-1 has excellent sensitivity and specificity for the diagnosis of follicular carcinoma (Rev Méd Chile 2004; 132: 279-84).
author	Moyano S,Leonor Franco T,Carmen Carreño T,Laura Robinson M,Patricia Sánchez J,Gabriel
author_facet	Moyano S,Leonor Franco T,Carmen Carreño T,Laura Robinson M,Patricia Sánchez J,Gabriel
author_sort	Moyano S,Leonor
title	HBME-1 y ciclina D1: marcadores diagnósticos de carcinoma folicular del tiroides
title_short	HBME-1 y ciclina D1: marcadores diagnósticos de carcinoma folicular del tiroides
title_full	HBME-1 y ciclina D1: marcadores diagnósticos de carcinoma folicular del tiroides
title_fullStr	HBME-1 y ciclina D1: marcadores diagnósticos de carcinoma folicular del tiroides
title_full_unstemmed	HBME-1 y ciclina D1: marcadores diagnósticos de carcinoma folicular del tiroides
title_sort	hbme-1 y ciclina d1: marcadores diagnósticos de carcinoma folicular del tiroides
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300001
work_keys_str_mv	AT moyanosleonor hbme1yciclinad1marcadoresdiagnosticosdecarcinomafoliculardeltiroides AT francotcarmen hbme1yciclinad1marcadoresdiagnosticosdecarcinomafoliculardeltiroides AT carrenotlaura hbme1yciclinad1marcadoresdiagnosticosdecarcinomafoliculardeltiroides AT robinsonmpatricia hbme1yciclinad1marcadoresdiagnosticosdecarcinomafoliculardeltiroides AT sanchezjgabriel hbme1yciclinad1marcadoresdiagnosticosdecarcinomafoliculardeltiroides
_version_	1718436138658562048

HBME-1 y ciclina D1: marcadores diagnósticos de carcinoma folicular del tiroides

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