Octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntrico

Background: Acute variceal bleeding in cirrhotic patients is an emergency with a high risk of rebleeding and death. Endoscopic procedures such as sclerotherapy or banding, combined or not with drugs such as octreotide could be considered. Aim: To assess the value of octreotide in the control of acut...

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Autores principales:	Silva P,Guillermo, Quera P,Rodrigo, Fluxá G,Fernando, Sanhueza B,Edgar, Segovia M,Roberto, Brahm B,Javier, Muñoz T,Cristián, Morales B,Antonio, Muñoz C,Lorena, Urzúa F,Luis, Biagini A,Leandro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Esophageal and gastric varices Gastrointestinal hemorrhage Hypertension Octreotide Portal
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300002
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spelling	oai:scielo:S0034-988720040003000022004-12-13Octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntricoSilva P,GuillermoQuera P,RodrigoFluxá G,FernandoSanhueza B,EdgarSegovia M,RobertoBrahm B,JavierMuñoz T,CristiánMorales B,AntonioMuñoz C,LorenaUrzúa F,LuisBiagini A,Leandro Esophageal and gastric varices Gastrointestinal hemorrhage Hypertension Octreotide Portal Background: Acute variceal bleeding in cirrhotic patients is an emergency with a high risk of rebleeding and death. Endoscopic procedures such as sclerotherapy or banding, combined or not with drugs such as octreotide could be considered. Aim: To assess the value of octreotide in the control of acute variceal bleeding. Patients and methods: Ninety-two patients were randomized into three groups: endoscopic therapy plus octreotide 50 µg/h bolus and continuous infusion for 5 days (n= 36); octreotide (same dosage) (n= 13) and endoscopic therapy only (banding and/or sclerotherapy) (n= 43). Results: Haemostasis at 24 hours was achieved in 97% of patients with combined treatment, 69% of patients receiving octreotide, and 93% of patients with endoscopic therapy (p= 0.2). Three patients with combined treatment, four patients receiving octreotide and eight patients with endoscopic therapy, rebled during the first five days (p= 0.15). The mean of blood units transfused was similar in the three groups. No differences were observed in hospital days and side effects. At 42 days of follow up, eight patients with endoscopic therapy, one patients with combined therapy and 2 patients receiving octreotide, died (p=NS). Conclusions: Octreotide is useful in the management of acute variceal bleeding. The absence of important side effects, renders it as a safe adjuvant treatment associated with endoscopic treatment (Rev Méd Chile 2004; 132: 285-94).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.3 20042004-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300002es10.4067/S0034-98872004000300002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Esophageal and gastric varices Gastrointestinal hemorrhage Hypertension Octreotide Portal
spellingShingle	Esophageal and gastric varices Gastrointestinal hemorrhage Hypertension Octreotide Portal Silva P,Guillermo Quera P,Rodrigo Fluxá G,Fernando Sanhueza B,Edgar Segovia M,Roberto Brahm B,Javier Muñoz T,Cristián Morales B,Antonio Muñoz C,Lorena Urzúa F,Luis Biagini A,Leandro Octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntrico
description	Background: Acute variceal bleeding in cirrhotic patients is an emergency with a high risk of rebleeding and death. Endoscopic procedures such as sclerotherapy or banding, combined or not with drugs such as octreotide could be considered. Aim: To assess the value of octreotide in the control of acute variceal bleeding. Patients and methods: Ninety-two patients were randomized into three groups: endoscopic therapy plus octreotide 50 µg/h bolus and continuous infusion for 5 days (n= 36); octreotide (same dosage) (n= 13) and endoscopic therapy only (banding and/or sclerotherapy) (n= 43). Results: Haemostasis at 24 hours was achieved in 97% of patients with combined treatment, 69% of patients receiving octreotide, and 93% of patients with endoscopic therapy (p= 0.2). Three patients with combined treatment, four patients receiving octreotide and eight patients with endoscopic therapy, rebled during the first five days (p= 0.15). The mean of blood units transfused was similar in the three groups. No differences were observed in hospital days and side effects. At 42 days of follow up, eight patients with endoscopic therapy, one patients with combined therapy and 2 patients receiving octreotide, died (p=NS). Conclusions: Octreotide is useful in the management of acute variceal bleeding. The absence of important side effects, renders it as a safe adjuvant treatment associated with endoscopic treatment (Rev Méd Chile 2004; 132: 285-94).
author	Silva P,Guillermo Quera P,Rodrigo Fluxá G,Fernando Sanhueza B,Edgar Segovia M,Roberto Brahm B,Javier Muñoz T,Cristián Morales B,Antonio Muñoz C,Lorena Urzúa F,Luis Biagini A,Leandro
author_facet	Silva P,Guillermo Quera P,Rodrigo Fluxá G,Fernando Sanhueza B,Edgar Segovia M,Roberto Brahm B,Javier Muñoz T,Cristián Morales B,Antonio Muñoz C,Lorena Urzúa F,Luis Biagini A,Leandro
author_sort	Silva P,Guillermo
title	Octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntrico
title_short	Octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntrico
title_full	Octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntrico
title_fullStr	Octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntrico
title_full_unstemmed	Octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntrico
title_sort	octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntrico
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300002
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Octreótido, tratamiento endoscópico o ambos en la hemorragia variceal activa enpacientes cirróticos: estudio multicéntrico

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