Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria

Iloprost, a prostacyclin analogue administered by inhalation, improves hemodynamic and functional class variables in patients with primary pulmonary hypertension. However, repetitive inhalations are required due to its short term effects. One potential approach to prolong and increase the effects of...

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Autores principales:	Isa P,Rodrigo, Castro G,Pablo, Martínez S,Alejandro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Iloprost Phosphodiesterase inhibitors Pulmonary heart disease Sildenafil
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300011
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spelling	oai:scielo:S0034-988720040003000112004-12-13Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primariaIsa P,RodrigoCastro G,PabloMartínez S,Alejandro Iloprost Phosphodiesterase inhibitors Pulmonary heart disease Sildenafil Iloprost, a prostacyclin analogue administered by inhalation, improves hemodynamic and functional class variables in patients with primary pulmonary hypertension. However, repetitive inhalations are required due to its short term effects. One potential approach to prolong and increase the effects of aerosolized iloprost might be to combine its use with phosphodiesterase inhibitors. We report a 36 years old female patient with primary pulmonary hypertension treated with this combination. After 18 months of therapy the patient had an improvement in functional class and in the 6 min walk distance despite persistence of high pulmonary pressures. Our case is in agreement with the reported beneficial effect of the association of sildenafil and iloprost. We postulate that functional improvement in primary pulmonary hypertension is not always related to a decrease in pulmonary artery pressure (Rev Méd Chile 2004; 132: 353-6).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.3 20042004-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300011es10.4067/S0034-98872004000300011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Iloprost Phosphodiesterase inhibitors Pulmonary heart disease Sildenafil
spellingShingle	Iloprost Phosphodiesterase inhibitors Pulmonary heart disease Sildenafil Isa P,Rodrigo Castro G,Pablo Martínez S,Alejandro Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria
description	Iloprost, a prostacyclin analogue administered by inhalation, improves hemodynamic and functional class variables in patients with primary pulmonary hypertension. However, repetitive inhalations are required due to its short term effects. One potential approach to prolong and increase the effects of aerosolized iloprost might be to combine its use with phosphodiesterase inhibitors. We report a 36 years old female patient with primary pulmonary hypertension treated with this combination. After 18 months of therapy the patient had an improvement in functional class and in the 6 min walk distance despite persistence of high pulmonary pressures. Our case is in agreement with the reported beneficial effect of the association of sildenafil and iloprost. We postulate that functional improvement in primary pulmonary hypertension is not always related to a decrease in pulmonary artery pressure (Rev Méd Chile 2004; 132: 353-6).
author	Isa P,Rodrigo Castro G,Pablo Martínez S,Alejandro
author_facet	Isa P,Rodrigo Castro G,Pablo Martínez S,Alejandro
author_sort	Isa P,Rodrigo
title	Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria
title_short	Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria
title_full	Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria
title_fullStr	Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria
title_full_unstemmed	Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria
title_sort	tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300011
work_keys_str_mv	AT isaprodrigo tratamientocronicocombinadoconiloprostysildenafilenunpacienteconhipertensionpulmonarprimaria AT castrogpablo tratamientocronicocombinadoconiloprostysildenafilenunpacienteconhipertensionpulmonarprimaria AT martinezsalejandro tratamientocronicocombinadoconiloprostysildenafilenunpacienteconhipertensionpulmonarprimaria
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Tratamiento crónico combinado con iloprost y sildenafil en un paciente con hipertensión pulmonar primaria

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