La detección antígeno-específica de linfocitos T y sus aplicaciones clínicas

The important role that T lymphocytes play during the immune response against pathogens and tumor cells has encouraged the development of technologies aimed to detect these immune cells in an antigen-specific fashion. Recently, a methodology consisting of the production of soluble ligands that bind...

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Autores principales:	Kalergis P,Alexis M, Fierro,Alberto, Figueroa G,Claudio, González M,Pablo, Tobar R,Jaime
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Histocompatibility antigens Immunity, cellular T Lymphocytes
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300014
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spelling	oai:scielo:S0034-988720040003000142004-12-13La detección antígeno-específica de linfocitos T y sus aplicaciones clínicasKalergis P,Alexis MFierro,AlbertoFigueroa G,ClaudioGonzález M,PabloTobar R,Jaime Histocompatibility antigens Immunity, cellular T Lymphocytes The important role that T lymphocytes play during the immune response against pathogens and tumor cells has encouraged the development of technologies aimed to detect these immune cells in an antigen-specific fashion. Recently, a methodology consisting of the production of soluble ligands that bind the T lymphocyte receptor was developed. Such ligands consist of molecules from the Major Histocompatibility Complex loaded with either pathogen or tumor derived peptides. These molecular complexes are tetramerized to enhance the binding efficiency to the T cell receptor (TCR), which improves the detection sensitivity of antigen specific T lymphocytes. This new technology is currently used successfully during the follow up patients that were vaccinated against certain tumor antigens, to evaluate the expansion of tumor specific T lymphocytes. This methodology is also promising for the detection and specific deletion of autoreactive T lymphocytes as a treatment for autoimmune disorders. In this article we review the molecular components involved in antigen recognition by T lymphocytes, and the potential benefits for Biomedicine that could result from the detection of these cells by soluble specific ligands (Rev Méd Chile 2004; 132: 371-80).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.3 20042004-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300014es10.4067/S0034-98872004000300014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Histocompatibility antigens Immunity, cellular T Lymphocytes
spellingShingle	Histocompatibility antigens Immunity, cellular T Lymphocytes Kalergis P,Alexis M Fierro,Alberto Figueroa G,Claudio González M,Pablo Tobar R,Jaime La detección antígeno-específica de linfocitos T y sus aplicaciones clínicas
description	The important role that T lymphocytes play during the immune response against pathogens and tumor cells has encouraged the development of technologies aimed to detect these immune cells in an antigen-specific fashion. Recently, a methodology consisting of the production of soluble ligands that bind the T lymphocyte receptor was developed. Such ligands consist of molecules from the Major Histocompatibility Complex loaded with either pathogen or tumor derived peptides. These molecular complexes are tetramerized to enhance the binding efficiency to the T cell receptor (TCR), which improves the detection sensitivity of antigen specific T lymphocytes. This new technology is currently used successfully during the follow up patients that were vaccinated against certain tumor antigens, to evaluate the expansion of tumor specific T lymphocytes. This methodology is also promising for the detection and specific deletion of autoreactive T lymphocytes as a treatment for autoimmune disorders. In this article we review the molecular components involved in antigen recognition by T lymphocytes, and the potential benefits for Biomedicine that could result from the detection of these cells by soluble specific ligands (Rev Méd Chile 2004; 132: 371-80).
author	Kalergis P,Alexis M Fierro,Alberto Figueroa G,Claudio González M,Pablo Tobar R,Jaime
author_facet	Kalergis P,Alexis M Fierro,Alberto Figueroa G,Claudio González M,Pablo Tobar R,Jaime
author_sort	Kalergis P,Alexis M
title	La detección antígeno-específica de linfocitos T y sus aplicaciones clínicas
title_short	La detección antígeno-específica de linfocitos T y sus aplicaciones clínicas
title_full	La detección antígeno-específica de linfocitos T y sus aplicaciones clínicas
title_fullStr	La detección antígeno-específica de linfocitos T y sus aplicaciones clínicas
title_full_unstemmed	La detección antígeno-específica de linfocitos T y sus aplicaciones clínicas
title_sort	la detección antígeno-específica de linfocitos t y sus aplicaciones clínicas
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000300014
work_keys_str_mv	AT kalergispalexism ladeteccionantigenoespecificadelinfocitostysusaplicacionesclinicas AT fierroalberto ladeteccionantigenoespecificadelinfocitostysusaplicacionesclinicas AT figueroagclaudio ladeteccionantigenoespecificadelinfocitostysusaplicacionesclinicas AT gonzalezmpablo ladeteccionantigenoespecificadelinfocitostysusaplicacionesclinicas AT tobarrjaime ladeteccionantigenoespecificadelinfocitostysusaplicacionesclinicas
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La detección antígeno-específica de linfocitos T y sus aplicaciones clínicas

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