Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos

Background: High density lipoprotein (HDL) cholesterol is inversely associated to atherosclerotic cardiovascular risk. Disturbances in HDL cholesterol plasma leves are frecuent in the Chilean population, however the pathophysiological mechanisms are unknown. Aim: To evaluate the mechanisms involved...

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Autores principales:	Cuevas M,Ada, Alvarez V,Verónica, Acosta B,Ana María, Altayó F,Marcela, Montero L,Joaquín, Rigotti R,Attilio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Lecithin acyltransferasa deficiency Lipoproteins, HDL Lipoproteins, HDL cholesterol Lipoproteins, VLDL cholesterol
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000400003
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spelling	oai:scielo:S0034-988720040004000032004-12-13Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenosCuevas M,AdaAlvarez V,VerónicaAcosta B,Ana MaríaAltayó F,MarcelaMontero L,JoaquínRigotti R,Attilio Lecithin acyltransferasa deficiency Lipoproteins, HDL Lipoproteins, HDL cholesterol Lipoproteins, VLDL cholesterol Background: High density lipoprotein (HDL) cholesterol is inversely associated to atherosclerotic cardiovascular risk. Disturbances in HDL cholesterol plasma leves are frecuent in the Chilean population, however the pathophysiological mechanisms are unknown. Aim: To evaluate the mechanisms involved in the hypo and hyper alfalipoproteinemias in Chilean subjects. Materials and Methods: Twenty three subjects with hyperalphalipoproteinemia and 12 with hypoalphalipoproteinemia, paired with control subjects (col-HDL between 35 and 55 mg/dl) were studied. We measured plasma lipids, subfractions and sizing of HDL particles and enzymatic activity of cholesteryl ester transfer protein (CETP), lecithin: cholesterol acyltransferase (LCAT), lipoprotein lipase (LPL) and hepatic lipase (LH). Results: Subjects with hyperalphalipoproteinemia showed significantly higher levels of total HDL-cholesterol (70±2 vs 44±1 mg/dl), HDL 2 (30±3 vs 5±1 mg/dl), Apo A I (175±3 vs 146±4 mg/dl), lower HL activity (23,7±0,8 vs 32,4±1,8 mmol/h/l) and HDL particles of greater size, compared to their controls. Subjects with hypoalphalipoproteinemia, showed significantly lower levels of total HDL-cholesterol (26±1 vs 48±2 mg/dl), HDL 3 (21±1 vs 40±2 mg/dl), Apo A I (107±5 vs 145±7 mg/dl), lower LCAT activity (18,6±1,9 vs 26,2±1,6 nmol/h/ml) and smaller HDL particles, compared to their controls. Conclusion: Changes in hepatic lipase and lecithin cholesterol acyltransferase activities may explain the hyper and hypo alphalipoproteinemia respectively, in Chilean subjects (Rev Méd Chile 2004; 132: 421-8)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.4 20042004-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000400003es10.4067/S0034-98872004000400003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Lecithin acyltransferasa deficiency Lipoproteins, HDL Lipoproteins, HDL cholesterol Lipoproteins, VLDL cholesterol
spellingShingle	Lecithin acyltransferasa deficiency Lipoproteins, HDL Lipoproteins, HDL cholesterol Lipoproteins, VLDL cholesterol Cuevas M,Ada Alvarez V,Verónica Acosta B,Ana María Altayó F,Marcela Montero L,Joaquín Rigotti R,Attilio Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos
description	Background: High density lipoprotein (HDL) cholesterol is inversely associated to atherosclerotic cardiovascular risk. Disturbances in HDL cholesterol plasma leves are frecuent in the Chilean population, however the pathophysiological mechanisms are unknown. Aim: To evaluate the mechanisms involved in the hypo and hyper alfalipoproteinemias in Chilean subjects. Materials and Methods: Twenty three subjects with hyperalphalipoproteinemia and 12 with hypoalphalipoproteinemia, paired with control subjects (col-HDL between 35 and 55 mg/dl) were studied. We measured plasma lipids, subfractions and sizing of HDL particles and enzymatic activity of cholesteryl ester transfer protein (CETP), lecithin: cholesterol acyltransferase (LCAT), lipoprotein lipase (LPL) and hepatic lipase (LH). Results: Subjects with hyperalphalipoproteinemia showed significantly higher levels of total HDL-cholesterol (70±2 vs 44±1 mg/dl), HDL 2 (30±3 vs 5±1 mg/dl), Apo A I (175±3 vs 146±4 mg/dl), lower HL activity (23,7±0,8 vs 32,4±1,8 mmol/h/l) and HDL particles of greater size, compared to their controls. Subjects with hypoalphalipoproteinemia, showed significantly lower levels of total HDL-cholesterol (26±1 vs 48±2 mg/dl), HDL 3 (21±1 vs 40±2 mg/dl), Apo A I (107±5 vs 145±7 mg/dl), lower LCAT activity (18,6±1,9 vs 26,2±1,6 nmol/h/ml) and smaller HDL particles, compared to their controls. Conclusion: Changes in hepatic lipase and lecithin cholesterol acyltransferase activities may explain the hyper and hypo alphalipoproteinemia respectively, in Chilean subjects (Rev Méd Chile 2004; 132: 421-8)
author	Cuevas M,Ada Alvarez V,Verónica Acosta B,Ana María Altayó F,Marcela Montero L,Joaquín Rigotti R,Attilio
author_facet	Cuevas M,Ada Alvarez V,Verónica Acosta B,Ana María Altayó F,Marcela Montero L,Joaquín Rigotti R,Attilio
author_sort	Cuevas M,Ada
title	Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos
title_short	Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos
title_full	Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos
title_fullStr	Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos
title_full_unstemmed	Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos
title_sort	mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000400003
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Mecanismos de hipo e hiper alfalipoproteinemia en individuos adultos chilenos

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