Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en Chile

Background: The real prevalence of dementia in a given population must be determined through prevalence studies, using validated screening tests. Aim: To validate and determine cutoff points for a cognitive impairment screening test composed by the Folstein Mini Mental State Examination (MMSE) and P...

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Autores principales:	Quiroga L,Pilar, Albala B,Cecilia, Klaasen P,Gonzalo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Cognition disordes Cognitive symptoms Dementia
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000400009
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spelling	oai:scielo:S0034-988720040004000092004-12-13Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en ChileQuiroga L,PilarAlbala B,CeciliaKlaasen P,Gonzalo Cognition disordes Cognitive symptoms Dementia Background: The real prevalence of dementia in a given population must be determined through prevalence studies, using validated screening tests. Aim: To validate and determine cutoff points for a cognitive impairment screening test composed by the Folstein Mini Mental State Examination (MMSE) and Pfeffer Functional Activities Questionnaire (PFAQ). Material and methods: Validation of the diagnostic test in a sample of 100 subjects over 65 years old (85 from the project «Age associated dementias» and 15 with a confirmed diagnosis of dementia). All were subjected to a complete neuropsychological test by a trained neurologist, that constituted the «gold standard» for the diagnosis of dementia. An independent interviewer applied the MMSE to the subjects and the PFAQ to a next of kin informer. Cutoff points were calculated using ROC curves. The points with the better equilibrium between sensitivity and specificity were selected, considering differences in results between groups with low and high educational level. Results: The cutoff point for MMSE was 21/22, with a sensitivity of 93.6% (95% CI 70.6-99.7%) and a specificity of 46.1% (95% CI 34.7-57.8%). The figure for PFAQ was 5/6, with a sensitivity of 89.2% (95% CI 70.6-99.7%) and a specificity of 70.7% (95% CI 58.9-80.3%). The combination of both instruments gave a sensitivity of 94.4% (95% CI 58.9-80.3%) and a specificity of 83.3% (95% CI 72.3-90.7%). Conclusions: This screening test, using MMSE and PFAQ, has a good sensitivity and specificity for the diagnosis of dementia in Chile. Being simple and of low cost, it can be applied in primary health care (Rev Méd Chile 2004; 132: 467-78)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.4 20042004-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000400009es10.4067/S0034-98872004000400009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cognition disordes Cognitive symptoms Dementia
spellingShingle	Cognition disordes Cognitive symptoms Dementia Quiroga L,Pilar Albala B,Cecilia Klaasen P,Gonzalo Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en Chile
description	Background: The real prevalence of dementia in a given population must be determined through prevalence studies, using validated screening tests. Aim: To validate and determine cutoff points for a cognitive impairment screening test composed by the Folstein Mini Mental State Examination (MMSE) and Pfeffer Functional Activities Questionnaire (PFAQ). Material and methods: Validation of the diagnostic test in a sample of 100 subjects over 65 years old (85 from the project «Age associated dementias» and 15 with a confirmed diagnosis of dementia). All were subjected to a complete neuropsychological test by a trained neurologist, that constituted the «gold standard» for the diagnosis of dementia. An independent interviewer applied the MMSE to the subjects and the PFAQ to a next of kin informer. Cutoff points were calculated using ROC curves. The points with the better equilibrium between sensitivity and specificity were selected, considering differences in results between groups with low and high educational level. Results: The cutoff point for MMSE was 21/22, with a sensitivity of 93.6% (95% CI 70.6-99.7%) and a specificity of 46.1% (95% CI 34.7-57.8%). The figure for PFAQ was 5/6, with a sensitivity of 89.2% (95% CI 70.6-99.7%) and a specificity of 70.7% (95% CI 58.9-80.3%). The combination of both instruments gave a sensitivity of 94.4% (95% CI 58.9-80.3%) and a specificity of 83.3% (95% CI 72.3-90.7%). Conclusions: This screening test, using MMSE and PFAQ, has a good sensitivity and specificity for the diagnosis of dementia in Chile. Being simple and of low cost, it can be applied in primary health care (Rev Méd Chile 2004; 132: 467-78)
author	Quiroga L,Pilar Albala B,Cecilia Klaasen P,Gonzalo
author_facet	Quiroga L,Pilar Albala B,Cecilia Klaasen P,Gonzalo
author_sort	Quiroga L,Pilar
title	Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en Chile
title_short	Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en Chile
title_full	Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en Chile
title_fullStr	Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en Chile
title_full_unstemmed	Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en Chile
title_sort	validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en chile
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000400009
work_keys_str_mv	AT quirogalpilar validaciondeuntestdetamizajeparaeldiagnosticodedemenciaasociadaaedadenchile AT albalabcecilia validaciondeuntestdetamizajeparaeldiagnosticodedemenciaasociadaaedadenchile AT klaasenpgonzalo validaciondeuntestdetamizajeparaeldiagnosticodedemenciaasociadaaedadenchile
_version_	1718436144896540672

Validación de un test de tamizaje para el diagnóstico de demencia asociada a edad, en Chile

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