Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae

Background : Streptococcus agalactiae or group B streptococcus, GBS, is the leading cause of neonatal and maternal infections and an opportunistic pathogen in adults with underlying disease. In the last decade, a dramatic increase in the resistance of this microorganism to erythromycin and clindamyc...

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Autores principales:	Martínez T,María Angélica, Ovalle S,Alfredo, Durán T,Claudia, Reid S,Iván, Urriola J,Gabriela, Garay G,Beatriz, Cifuentes D,Marcela
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Drug resistance, microbial Serotyping Streptococcus agalactiae
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000500003
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spelling	oai:scielo:S0034-988720040005000032005-11-18Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiaeMartínez T,María AngélicaOvalle S,AlfredoDurán T,ClaudiaReid S,IvánUrriola J,GabrielaGaray G,BeatrizCifuentes D,Marcela Drug resistance, microbial Serotyping Streptococcus agalactiae Background : Streptococcus agalactiae or group B streptococcus, GBS, is the leading cause of neonatal and maternal infections and an opportunistic pathogen in adults with underlying disease. In the last decade, a dramatic increase in the resistance of this microorganism to erythromycin and clindamycin has been observed. Aim: To determine the serotype distribution and antimicrobial susceptibility of isolates of S agalactiae collected from infections and colonization and to assess the genetic mechanisms of macrolide and clindamycin resistance. Material and methods: A total of 100 GBS isolates were collected between 1998 and 2002, in Santiago, Chile. They were isolated from the amniotic fluid from patients with premature rupture of membranes (7 isolates), blood from neonatal sepsis (10 isolates), neonate colonizations (2 strains), skin and soft tissue infections (7 isolates), urinary tract infections (5 isolates), genital infections (3 isolates), articular fluid (one isolate), and 65 strains were recovered from vaginal colonization55. Results: Serotypes Ia, II and III were the predominant serotypes identified in our study, accounting for 90 (90%) of the strains. Five isolates belonged to serotypes Ib (5%) and two (2%) to serotype V respectively; no strains belonging to serotype IV were found. All strains were susceptible to penicillin G, ampicillin and cefotaxime, and four isolates (4%) were resistant to both erythromycin (MIC >64 µg/ml) and clindamycin (MIC >64 µg/ml). The strains had a constitutive macrolide-lincosamide-streptogramin (cMLSB) resistance phenotype and the erm(A) gene was present in the four isolates. Conclusions: Serotypes Ia, II and III were the predominant serotypes in this study. All strains were susceptible to penicillin G, ampicillin and cefotaxime, and four (4%) strains were resistant to both erythromycin and clindamycin. The cMLSB resistance phenotype, and the erm(A) gene was detected in resistant strains (Rev Méd Chile 2004; 132: 549-55).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.5 20042004-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000500003es10.4067/S0034-98872004000500003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Drug resistance, microbial Serotyping Streptococcus agalactiae
spellingShingle	Drug resistance, microbial Serotyping Streptococcus agalactiae Martínez T,María Angélica Ovalle S,Alfredo Durán T,Claudia Reid S,Iván Urriola J,Gabriela Garay G,Beatriz Cifuentes D,Marcela Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae
description	Background : Streptococcus agalactiae or group B streptococcus, GBS, is the leading cause of neonatal and maternal infections and an opportunistic pathogen in adults with underlying disease. In the last decade, a dramatic increase in the resistance of this microorganism to erythromycin and clindamycin has been observed. Aim: To determine the serotype distribution and antimicrobial susceptibility of isolates of S agalactiae collected from infections and colonization and to assess the genetic mechanisms of macrolide and clindamycin resistance. Material and methods: A total of 100 GBS isolates were collected between 1998 and 2002, in Santiago, Chile. They were isolated from the amniotic fluid from patients with premature rupture of membranes (7 isolates), blood from neonatal sepsis (10 isolates), neonate colonizations (2 strains), skin and soft tissue infections (7 isolates), urinary tract infections (5 isolates), genital infections (3 isolates), articular fluid (one isolate), and 65 strains were recovered from vaginal colonization55. Results: Serotypes Ia, II and III were the predominant serotypes identified in our study, accounting for 90 (90%) of the strains. Five isolates belonged to serotypes Ib (5%) and two (2%) to serotype V respectively; no strains belonging to serotype IV were found. All strains were susceptible to penicillin G, ampicillin and cefotaxime, and four isolates (4%) were resistant to both erythromycin (MIC >64 µg/ml) and clindamycin (MIC >64 µg/ml). The strains had a constitutive macrolide-lincosamide-streptogramin (cMLSB) resistance phenotype and the erm(A) gene was present in the four isolates. Conclusions: Serotypes Ia, II and III were the predominant serotypes in this study. All strains were susceptible to penicillin G, ampicillin and cefotaxime, and four (4%) strains were resistant to both erythromycin and clindamycin. The cMLSB resistance phenotype, and the erm(A) gene was detected in resistant strains (Rev Méd Chile 2004; 132: 549-55).
author	Martínez T,María Angélica Ovalle S,Alfredo Durán T,Claudia Reid S,Iván Urriola J,Gabriela Garay G,Beatriz Cifuentes D,Marcela
author_facet	Martínez T,María Angélica Ovalle S,Alfredo Durán T,Claudia Reid S,Iván Urriola J,Gabriela Garay G,Beatriz Cifuentes D,Marcela
author_sort	Martínez T,María Angélica
title	Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae
title_short	Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae
title_full	Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae
title_fullStr	Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae
title_full_unstemmed	Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae
title_sort	serotipos y susceptibilidad antimicrobiana de streptococcus agalactiae
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000500003
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Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae

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