Tumores neuroendocrinos del páncreas

All pancreatic neuroendocrine tumors derive from Langerhans islet cells and have a low incidence. Half of them are functioning tumors that produce diverse hormones and occasionally cause serious clinical endocrine syndromes. They may be malignant, but they have a better survival, if compared to panc...

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Autores principales:	Burgos S J,Luis, Burgos de C.,María Eugenia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Langerhans cells Neuroendocrine tumors Pancreatic neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000500014
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spelling	oai:scielo:S0034-988720040005000142005-11-18Tumores neuroendocrinos del páncreasBurgos S J,LuisBurgos de C.,María Eugenia Langerhans cells Neuroendocrine tumors Pancreatic neoplasms All pancreatic neuroendocrine tumors derive from Langerhans islet cells and have a low incidence. Half of them are functioning tumors that produce diverse hormones and occasionally cause serious clinical endocrine syndromes. They may be malignant, but they have a better survival, if compared to pancreatic ductal adenocarcinoma. Insulinoma, gastrinoma, glucagonoma, VIPoma (VIP=vasoactive intestinal peptide), somatostatinoma and ACTHoma are functioning tumors and they may also be part of Multiple Endocrine Neoplasia type I (MEN 1) syndrome and of von Hippel-Lindau disease. Diagnosis of non-functioning tumors is usually late, when they reach a big size and have even developed nodal and hepatic metastases. Nowadays, there are effective medical treatments for the medical problems secondary to excessive hormone production. For example, the hypergastrinemia typical of the Zollinger-Ellison syndrome in gastrinoma, can be adequately managed. Surgical resection is the most advisable therapy for pancreatic endocrine tumors, especially when they are small, when long time survival is better. Pre and intra operative imagenology is a great aid to locate these tumors. There are several surgical alternatives, according to the tumor size and location within the pancreas. Furthermore, palliative therapy can be used in disseminated disease. Treatment success is the result of a multidisciplinary medical team work of endocrinologists, surgeons, gastroenterologists, pathologists and geneticists (Rev Méd Chile 2004; 132: 627-34).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.5 20042004-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000500014es10.4067/S0034-98872004000500014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Langerhans cells Neuroendocrine tumors Pancreatic neoplasms
spellingShingle	Langerhans cells Neuroendocrine tumors Pancreatic neoplasms Burgos S J,Luis Burgos de C.,María Eugenia Tumores neuroendocrinos del páncreas
description	All pancreatic neuroendocrine tumors derive from Langerhans islet cells and have a low incidence. Half of them are functioning tumors that produce diverse hormones and occasionally cause serious clinical endocrine syndromes. They may be malignant, but they have a better survival, if compared to pancreatic ductal adenocarcinoma. Insulinoma, gastrinoma, glucagonoma, VIPoma (VIP=vasoactive intestinal peptide), somatostatinoma and ACTHoma are functioning tumors and they may also be part of Multiple Endocrine Neoplasia type I (MEN 1) syndrome and of von Hippel-Lindau disease. Diagnosis of non-functioning tumors is usually late, when they reach a big size and have even developed nodal and hepatic metastases. Nowadays, there are effective medical treatments for the medical problems secondary to excessive hormone production. For example, the hypergastrinemia typical of the Zollinger-Ellison syndrome in gastrinoma, can be adequately managed. Surgical resection is the most advisable therapy for pancreatic endocrine tumors, especially when they are small, when long time survival is better. Pre and intra operative imagenology is a great aid to locate these tumors. There are several surgical alternatives, according to the tumor size and location within the pancreas. Furthermore, palliative therapy can be used in disseminated disease. Treatment success is the result of a multidisciplinary medical team work of endocrinologists, surgeons, gastroenterologists, pathologists and geneticists (Rev Méd Chile 2004; 132: 627-34).
author	Burgos S J,Luis Burgos de C.,María Eugenia
author_facet	Burgos S J,Luis Burgos de C.,María Eugenia
author_sort	Burgos S J,Luis
title	Tumores neuroendocrinos del páncreas
title_short	Tumores neuroendocrinos del páncreas
title_full	Tumores neuroendocrinos del páncreas
title_fullStr	Tumores neuroendocrinos del páncreas
title_full_unstemmed	Tumores neuroendocrinos del páncreas
title_sort	tumores neuroendocrinos del páncreas
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000500014
work_keys_str_mv	AT burgossjluis tumoresneuroendocrinosdelpancreas AT burgosdecmariaeugenia tumoresneuroendocrinosdelpancreas
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Tumores neuroendocrinos del páncreas

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