Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas

Background: Chile has a high frequency of gallbladder cancer. Polyps are common lesions of gallbladder mucosa but there is little information about their morphological features. Aim: To report the clinical and pathological features of 219 gallbladder polyps. Material and methods: Cholecystectomies s...

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Autores principales:	Roa E,Iván, Aretxabala U,Xabier de, Morgan F,René, Molina U,Ricardo, Araya O,Juan C, Roa S,Juan, Ibacahe S,Gilda
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Biliary tract surgical procedures Cholelithiasis Gallbladder neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000600003
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spelling	oai:scielo:S0034-988720040006000032014-08-14Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicasRoa E,IvánAretxabala U,Xabier deMorgan F,RenéMolina U,RicardoAraya O,Juan CRoa S,JuanIbacahe S,Gilda Biliary tract surgical procedures Cholelithiasis Gallbladder neoplasms Background: Chile has a high frequency of gallbladder cancer. Polyps are common lesions of gallbladder mucosa but there is little information about their morphological features. Aim: To report the clinical and pathological features of 219 gallbladder polyps. Material and methods: Cholecystectomies samples in which a polypoid lesion was diagnosed microscopically. In all cases, complete clinical information and digitalized images of the complete surgical specimens was reviewed. Results: In a period of 10 years, 21.412 gallbladders were processed. Among these, 884 carcinomas were diagnosed and in 219 cases (1%) a polyp was found. One hundred and eighty three patients were females (mean age 49.3 years) and 36 males (mean age 53.4 years). The preoperative diagnosis of gallbladder polyp was done only in 26 cases (12%). Eighty five percent of polyps were non-neoplastic (metaplastic in 32%, cholesterol in 29%, hyperplastic in 22% and inflammatory in 2%). The remaining 15% were adenomas. Seventy five percent of non-neoplastic polyps were located in the proximal half of the gallbladder and 88% of adenomas in the distal half. Ninety five percent of non-neoplastic polyps measured less than 10 mm. Among adenomas, 47% measured less than 5 mm and 28% more than 10 mm. Smaller polyps were of cholesterol and larger polyps were adenomas. Eight adenomas were associated with an adenocarcinoma, two had less than 5 mm lenght. Mean age of patients with adenomas associated to cancer was higher than patients with pure adenomas (64.6 and 44.3 years respectively, p >0.001). Conclusions: There are size and location differences between non neoplastic polyps and adenomas. Adenomas associated to cancer may measure less than 5 mm. Therefore the polyp size criteria to decide surgical behavior in symptomatic gallstone patients may be misleading (Rev Méd Chile 2004; 132: 673-9)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.6 20042004-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000600003es10.4067/S0034-98872004000600003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Biliary tract surgical procedures Cholelithiasis Gallbladder neoplasms
spellingShingle	Biliary tract surgical procedures Cholelithiasis Gallbladder neoplasms Roa E,Iván Aretxabala U,Xabier de Morgan F,René Molina U,Ricardo Araya O,Juan C Roa S,Juan Ibacahe S,Gilda Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas
description	Background: Chile has a high frequency of gallbladder cancer. Polyps are common lesions of gallbladder mucosa but there is little information about their morphological features. Aim: To report the clinical and pathological features of 219 gallbladder polyps. Material and methods: Cholecystectomies samples in which a polypoid lesion was diagnosed microscopically. In all cases, complete clinical information and digitalized images of the complete surgical specimens was reviewed. Results: In a period of 10 years, 21.412 gallbladders were processed. Among these, 884 carcinomas were diagnosed and in 219 cases (1%) a polyp was found. One hundred and eighty three patients were females (mean age 49.3 years) and 36 males (mean age 53.4 years). The preoperative diagnosis of gallbladder polyp was done only in 26 cases (12%). Eighty five percent of polyps were non-neoplastic (metaplastic in 32%, cholesterol in 29%, hyperplastic in 22% and inflammatory in 2%). The remaining 15% were adenomas. Seventy five percent of non-neoplastic polyps were located in the proximal half of the gallbladder and 88% of adenomas in the distal half. Ninety five percent of non-neoplastic polyps measured less than 10 mm. Among adenomas, 47% measured less than 5 mm and 28% more than 10 mm. Smaller polyps were of cholesterol and larger polyps were adenomas. Eight adenomas were associated with an adenocarcinoma, two had less than 5 mm lenght. Mean age of patients with adenomas associated to cancer was higher than patients with pure adenomas (64.6 and 44.3 years respectively, p >0.001). Conclusions: There are size and location differences between non neoplastic polyps and adenomas. Adenomas associated to cancer may measure less than 5 mm. Therefore the polyp size criteria to decide surgical behavior in symptomatic gallstone patients may be misleading (Rev Méd Chile 2004; 132: 673-9)
author	Roa E,Iván Aretxabala U,Xabier de Morgan F,René Molina U,Ricardo Araya O,Juan C Roa S,Juan Ibacahe S,Gilda
author_facet	Roa E,Iván Aretxabala U,Xabier de Morgan F,René Molina U,Ricardo Araya O,Juan C Roa S,Juan Ibacahe S,Gilda
author_sort	Roa E,Iván
title	Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas
title_short	Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas
title_full	Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas
title_fullStr	Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas
title_full_unstemmed	Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas
title_sort	pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000600003
work_keys_str_mv	AT roaeivan poliposyadenomasdelavesiculabiliarconsideracionesclinicopatologicas AT aretxabalauxabierde poliposyadenomasdelavesiculabiliarconsideracionesclinicopatologicas AT morganfrene poliposyadenomasdelavesiculabiliarconsideracionesclinicopatologicas AT molinauricardo poliposyadenomasdelavesiculabiliarconsideracionesclinicopatologicas AT arayaojuanc poliposyadenomasdelavesiculabiliarconsideracionesclinicopatologicas AT roasjuan poliposyadenomasdelavesiculabiliarconsideracionesclinicopatologicas AT ibacahesgilda poliposyadenomasdelavesiculabiliarconsideracionesclinicopatologicas
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Pólipos y adenomas de la vesícula biliar: consideraciones clínico-patológicas

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