Antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y recto

Background: CEA is widely used in the follow up of patients with colorectal carcinoma. Aim: To study the value of preoperative CEA as an independent prognostic factor in colorectal carcinoma. Patients and methods: Analysis of 373 operated patients (204 females, age range 21-92 years) with colorectal...

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Autores principales:	Bannura C,Guillermo, Cumsille G,Miguel A, Contreras P,Jaime, Barrera E,Alejandro, Melo L,Carlos, Soto C,Daniel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Carcinoembryonic antigen Colorectal neoplasms Neoplasm staging Tumor markers, biological
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000600005
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spelling	oai:scielo:S0034-988720040006000052014-08-14Antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y rectoBannura C,GuillermoCumsille G,Miguel AContreras P,JaimeBarrera E,AlejandroMelo L,CarlosSoto C,Daniel Carcinoembryonic antigen Colorectal neoplasms Neoplasm staging Tumor markers, biological Background: CEA is widely used in the follow up of patients with colorectal carcinoma. Aim: To study the value of preoperative CEA as an independent prognostic factor in colorectal carcinoma. Patients and methods: Analysis of 373 operated patients (204 females, age range 21-92 years) with colorectal carcinoma and a mean follow up of 53 months. The cutoff value for CEA was 5 ng/ml. Ninety four percent of patients had an excisable tumor, 79% had involvement of perirectal/pericolonic adipose tissue and 46% had lymph node involvement. Staging was done using Dukes-Turnbull and TNM classifications. Results: CEA was normal in 61% of cases, over 5 ng/ml in 39% and over 15 ng/ml in 22%. There was a strong correlation between mean preoperative CEA and tumor stage, depth and lymph node involvement. During the follow up, 140 patients died, 57 with normal and 83 with elevated CEA. Cancer mortality in patients subjected to a curative excision of the tumor (Dukes A-C2/TNM I-III) was 9% for colonic tumors and 36% for rectal tumors (p <0.001). There were no survival differences in patients with Dukes B/TNM II tumors according to preoperative CEA. Among Dukes C/TNM III tumors, survival difference was only significant for rectal tumors. A Cox model disclosed tumor stage, location and preoperative CEA as independent prognostic factors for survival. Conclusions: CEA is an independent prognostic factor for survival in colorectal carcinoma and high levels suggest an advanced disease (Rev Méd Chile 2004; 132: 691-700)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.6 20042004-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000600005es10.4067/S0034-98872004000600005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Carcinoembryonic antigen Colorectal neoplasms Neoplasm staging Tumor markers, biological
spellingShingle	Carcinoembryonic antigen Colorectal neoplasms Neoplasm staging Tumor markers, biological Bannura C,Guillermo Cumsille G,Miguel A Contreras P,Jaime Barrera E,Alejandro Melo L,Carlos Soto C,Daniel Antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y recto
description	Background: CEA is widely used in the follow up of patients with colorectal carcinoma. Aim: To study the value of preoperative CEA as an independent prognostic factor in colorectal carcinoma. Patients and methods: Analysis of 373 operated patients (204 females, age range 21-92 years) with colorectal carcinoma and a mean follow up of 53 months. The cutoff value for CEA was 5 ng/ml. Ninety four percent of patients had an excisable tumor, 79% had involvement of perirectal/pericolonic adipose tissue and 46% had lymph node involvement. Staging was done using Dukes-Turnbull and TNM classifications. Results: CEA was normal in 61% of cases, over 5 ng/ml in 39% and over 15 ng/ml in 22%. There was a strong correlation between mean preoperative CEA and tumor stage, depth and lymph node involvement. During the follow up, 140 patients died, 57 with normal and 83 with elevated CEA. Cancer mortality in patients subjected to a curative excision of the tumor (Dukes A-C2/TNM I-III) was 9% for colonic tumors and 36% for rectal tumors (p <0.001). There were no survival differences in patients with Dukes B/TNM II tumors according to preoperative CEA. Among Dukes C/TNM III tumors, survival difference was only significant for rectal tumors. A Cox model disclosed tumor stage, location and preoperative CEA as independent prognostic factors for survival. Conclusions: CEA is an independent prognostic factor for survival in colorectal carcinoma and high levels suggest an advanced disease (Rev Méd Chile 2004; 132: 691-700)
author	Bannura C,Guillermo Cumsille G,Miguel A Contreras P,Jaime Barrera E,Alejandro Melo L,Carlos Soto C,Daniel
author_facet	Bannura C,Guillermo Cumsille G,Miguel A Contreras P,Jaime Barrera E,Alejandro Melo L,Carlos Soto C,Daniel
author_sort	Bannura C,Guillermo
title	Antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y recto
title_short	Antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y recto
title_full	Antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y recto
title_fullStr	Antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y recto
title_full_unstemmed	Antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y recto
title_sort	antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y recto
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000600005
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Antígeno carcinoembrionario preoperatorio como factor pronóstico independiente en cáncer de colon y recto

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