Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar

Background: The clinical and morphological characterization of the subserous gallbladder carcinomas is controversial. Aim: To study the prognostic importance of DNA content of subserous gallbladder carcinoma. Material and methods: We studied 104 females aged 60±12 years old and 16 men aged 70±13 yea...

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Autores principales:	Roa E,Iván, Aretxabala U,Xabier de, Fuentealba A,Patricia, Cabrera C,María Elena, Araya O,Juan C, Roa S,Juan
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Adenocarcinoma DNA, neoplasm Gallbladder neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000700002
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spelling	oai:scielo:S0034-988720040007000022004-12-13Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliarRoa E,IvánAretxabala U,Xabier deFuentealba A,PatriciaCabrera C,María ElenaAraya O,Juan CRoa S,Juan Adenocarcinoma DNA, neoplasm Gallbladder neoplasms Background: The clinical and morphological characterization of the subserous gallbladder carcinomas is controversial. Aim: To study the prognostic importance of DNA content of subserous gallbladder carcinoma. Material and methods: We studied 104 females aged 60±12 years old and 16 men aged 70±13 years old. In all of them diagnosis was established after mapping of cholecystectomy sample and had a complete clinical follow up. DNA content was measured by flow cytometry. Results: All tumors were adenocarcinoma, and only 16% were well differentiated. Aneuploidy was observed in 29 cases (26%) with DNA index fluctuating between 1.1 and 1.8. Lymphatic vessel tumor involvement was present in 16 of 22 cases with aneuploidy and in 22 of 46 diploid tumors (p= 0.05). Eighty nine percent of aneuploid tumors were detected macroscopically and 11% were unapparent. Five years survival was non significantly better among patients with diploid tumors than in patients with aneuploid tumors (45 and 28%, respectively, p= 0.2). The histological differentiation was the only variable significantly associated with survival. Conclusions: Aneuploidy is present in 26% of subserous gallbladder carcinoma. It is not related with any of the morphological or clinical variables studied in this series of patients (Rev Méd Chile 2004; 132: 794-800)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.7 20042004-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000700002es10.4067/S0034-98872004000700002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Adenocarcinoma DNA, neoplasm Gallbladder neoplasms
spellingShingle	Adenocarcinoma DNA, neoplasm Gallbladder neoplasms Roa E,Iván Aretxabala U,Xabier de Fuentealba A,Patricia Cabrera C,María Elena Araya O,Juan C Roa S,Juan Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar
description	Background: The clinical and morphological characterization of the subserous gallbladder carcinomas is controversial. Aim: To study the prognostic importance of DNA content of subserous gallbladder carcinoma. Material and methods: We studied 104 females aged 60±12 years old and 16 men aged 70±13 years old. In all of them diagnosis was established after mapping of cholecystectomy sample and had a complete clinical follow up. DNA content was measured by flow cytometry. Results: All tumors were adenocarcinoma, and only 16% were well differentiated. Aneuploidy was observed in 29 cases (26%) with DNA index fluctuating between 1.1 and 1.8. Lymphatic vessel tumor involvement was present in 16 of 22 cases with aneuploidy and in 22 of 46 diploid tumors (p= 0.05). Eighty nine percent of aneuploid tumors were detected macroscopically and 11% were unapparent. Five years survival was non significantly better among patients with diploid tumors than in patients with aneuploid tumors (45 and 28%, respectively, p= 0.2). The histological differentiation was the only variable significantly associated with survival. Conclusions: Aneuploidy is present in 26% of subserous gallbladder carcinoma. It is not related with any of the morphological or clinical variables studied in this series of patients (Rev Méd Chile 2004; 132: 794-800)
author	Roa E,Iván Aretxabala U,Xabier de Fuentealba A,Patricia Cabrera C,María Elena Araya O,Juan C Roa S,Juan
author_facet	Roa E,Iván Aretxabala U,Xabier de Fuentealba A,Patricia Cabrera C,María Elena Araya O,Juan C Roa S,Juan
author_sort	Roa E,Iván
title	Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar
title_short	Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar
title_full	Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar
title_fullStr	Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar
title_full_unstemmed	Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar
title_sort	contenido de adn y sobrevida en el carcinoma subseroso de la vesícula biliar
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000700002
work_keys_str_mv	AT roaeivan contenidodeadnysobrevidaenelcarcinomasubserosodelavesiculabiliar AT aretxabalauxabierde contenidodeadnysobrevidaenelcarcinomasubserosodelavesiculabiliar AT fuentealbaapatricia contenidodeadnysobrevidaenelcarcinomasubserosodelavesiculabiliar AT cabreracmariaelena contenidodeadnysobrevidaenelcarcinomasubserosodelavesiculabiliar AT arayaojuanc contenidodeadnysobrevidaenelcarcinomasubserosodelavesiculabiliar AT roasjuan contenidodeadnysobrevidaenelcarcinomasubserosodelavesiculabiliar
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Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar

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