Exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: Análisis de la evidencia epidemiológica y experimental
Several epidemiological studies link pesticide exposure to reproductive and developmental toxicity. However, additional studies have shown little or no evidence to support such relationship. On the other hand, experimental data show that some pesticides may indeed alter the reproductive function or...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Médica de Santiago
2004
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| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000700014 |
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oai:scielo:S0034-988720040007000142004-12-13Exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: Análisis de la evidencia epidemiológica y experimentalCavieres F,María Fernanda Abnormalities Pesticides Toxic actions Several epidemiological studies link pesticide exposure to reproductive and developmental toxicity. However, additional studies have shown little or no evidence to support such relationship. On the other hand, experimental data show that some pesticides may indeed alter the reproductive function or produce birth defects (as evidenced by intrauterine death, in utero growth retardation, visceral and skeletal malformations or functional deficits) in laboratory animals. This review is a critical analysis of the epidemiological and experimental evidence available to date, that links pesticide exposure with induction of reproductive or developmental defects. Factors that must be considered when establishing a cause-effect relationship are also discussed, including the shape of the dose-response curve, exposure to pesticides in chemical mixtures and the influence of genetic background (Rev Méd Chile 2004; 132: 873-9info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.7 20042004-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000700014es10.4067/S0034-98872004000700014 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Abnormalities Pesticides Toxic actions |
| spellingShingle |
Abnormalities Pesticides Toxic actions Cavieres F,María Fernanda Exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: Análisis de la evidencia epidemiológica y experimental |
| description |
Several epidemiological studies link pesticide exposure to reproductive and developmental toxicity. However, additional studies have shown little or no evidence to support such relationship. On the other hand, experimental data show that some pesticides may indeed alter the reproductive function or produce birth defects (as evidenced by intrauterine death, in utero growth retardation, visceral and skeletal malformations or functional deficits) in laboratory animals. This review is a critical analysis of the epidemiological and experimental evidence available to date, that links pesticide exposure with induction of reproductive or developmental defects. Factors that must be considered when establishing a cause-effect relationship are also discussed, including the shape of the dose-response curve, exposure to pesticides in chemical mixtures and the influence of genetic background (Rev Méd Chile 2004; 132: 873-9 |
| author |
Cavieres F,María Fernanda |
| author_facet |
Cavieres F,María Fernanda |
| author_sort |
Cavieres F,María Fernanda |
| title |
Exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: Análisis de la evidencia epidemiológica y experimental |
| title_short |
Exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: Análisis de la evidencia epidemiológica y experimental |
| title_full |
Exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: Análisis de la evidencia epidemiológica y experimental |
| title_fullStr |
Exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: Análisis de la evidencia epidemiológica y experimental |
| title_full_unstemmed |
Exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: Análisis de la evidencia epidemiológica y experimental |
| title_sort |
exposición a pesticidas y toxicidad reproductiva y del desarrollo en humanos: análisis de la evidencia epidemiológica y experimental |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2004 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000700014 |
| work_keys_str_mv |
AT cavieresfmariafernanda exposicionapesticidasytoxicidadreproductivaydeldesarrolloenhumanosanalisisdelaevidenciaepidemiologicayexperimental |
| _version_ |
1718436159713968128 |