Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»

Background: The role of susceptibility low penetrance genes and environmental factors in the etiology of prostate cancer (PCa) is unclear, but may involve in some cases multiple alleles at multiple loci. Aim: To evaluate the association of gene-gene and gene-environment interactions with PCa. Patien...

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Autores principales:	Cáceres L,Dante, Iturrieta G,Jeannette, Acevedo C,Cristian, Huidobro A,Christian, Varela F,Nelson, Escala Z,Mario, Quiñones S,Luis
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Cytochrome P-450 CYP1A1 Glutathione S-transferase Polymorphism (Genetics) Prostatic neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000800008
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spelling	oai:scielo:S0034-988720040008000082014-08-14Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»Cáceres L,DanteIturrieta G,JeannetteAcevedo C,CristianHuidobro A,ChristianVarela F,NelsonEscala Z,MarioQuiñones S,Luis Cytochrome P-450 CYP1A1 Glutathione S-transferase Polymorphism (Genetics) Prostatic neoplasms Background: The role of susceptibility low penetrance genes and environmental factors in the etiology of prostate cancer (PCa) is unclear, but may involve in some cases multiple alleles at multiple loci. Aim: To evaluate the association of gene-gene and gene-environment interactions with PCa. Patients and methods: One hundred three subjects with biopsy proven PCa were studied, using a case-only design. All were interrogated about smoking habits. Polymorphisms for Glutathione-S-transferase (GST) and Cytochrome P4501A1 (CYP1A1), were measured in DNA extracted from peripheral Iymphocytes, using a restriction fragment length polymorphism analysis. Results: Our findings suggest that gene-gene interactions between GSTT1 and CYP1A1 high risk genotypes were positive modifiers and had a high predictive value for the presence of PCa, compared with non-susceptibility genotypes. The interaction between susceptibility genotypes and smoking did not modify the risk for PCa. Conclusions: Gene-gene interactions may play a role modulating the susceptibility to PCa in a proportion of affected individuals (Rev Méd Chile 2004; 132: 961-66).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.8 20042004-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000800008es10.4067/S0034-98872004000800008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cytochrome P-450 CYP1A1 Glutathione S-transferase Polymorphism (Genetics) Prostatic neoplasms
spellingShingle	Cytochrome P-450 CYP1A1 Glutathione S-transferase Polymorphism (Genetics) Prostatic neoplasms Cáceres L,Dante Iturrieta G,Jeannette Acevedo C,Cristian Huidobro A,Christian Varela F,Nelson Escala Z,Mario Quiñones S,Luis Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»
description	Background: The role of susceptibility low penetrance genes and environmental factors in the etiology of prostate cancer (PCa) is unclear, but may involve in some cases multiple alleles at multiple loci. Aim: To evaluate the association of gene-gene and gene-environment interactions with PCa. Patients and methods: One hundred three subjects with biopsy proven PCa were studied, using a case-only design. All were interrogated about smoking habits. Polymorphisms for Glutathione-S-transferase (GST) and Cytochrome P4501A1 (CYP1A1), were measured in DNA extracted from peripheral Iymphocytes, using a restriction fragment length polymorphism analysis. Results: Our findings suggest that gene-gene interactions between GSTT1 and CYP1A1 high risk genotypes were positive modifiers and had a high predictive value for the presence of PCa, compared with non-susceptibility genotypes. The interaction between susceptibility genotypes and smoking did not modify the risk for PCa. Conclusions: Gene-gene interactions may play a role modulating the susceptibility to PCa in a proportion of affected individuals (Rev Méd Chile 2004; 132: 961-66).
author	Cáceres L,Dante Iturrieta G,Jeannette Acevedo C,Cristian Huidobro A,Christian Varela F,Nelson Escala Z,Mario Quiñones S,Luis
author_facet	Cáceres L,Dante Iturrieta G,Jeannette Acevedo C,Cristian Huidobro A,Christian Varela F,Nelson Escala Z,Mario Quiñones S,Luis
author_sort	Cáceres L,Dante
title	Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»
title_short	Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»
title_full	Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»
title_fullStr	Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»
title_full_unstemmed	Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»
title_sort	interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000800008
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Interacciones genéticas y genético-ambientales como efecto modificador del riesgo de cáncer de próstata: un diseño «case-only»

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