Hiperinsulinismo neonatal persistente: Análisis del diagnóstico diferencial a propósito de dos casos clínicos

Persistent neonatal hyperinsulinism is the most common cause of refractory hypoglycemia during the first year of life. Inadequate insulin secretion is associated to mutations of four different genes, that can be diagnosed to orient patient management. We report two patients: a female newborn that pr...

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Autores principales:	Hernández C,M Isabel, Hodgson B,M Isabel, Cattani O,Andreina
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Endogenous hyperinsulism Hyperinsulism Hypoglicemia
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000800013
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id	oai:scielo:S0034-98872004000800013
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spelling	oai:scielo:S0034-988720040008000132014-08-14Hiperinsulinismo neonatal persistente: Análisis del diagnóstico diferencial a propósito de dos casos clínicosHernández C,M IsabelHodgson B,M IsabelCattani O,Andreina Endogenous hyperinsulism Hyperinsulism Hypoglicemia Persistent neonatal hyperinsulinism is the most common cause of refractory hypoglycemia during the first year of life. Inadequate insulin secretion is associated to mutations of four different genes, that can be diagnosed to orient patient management. We report two patients: a female newborn that presented a hypoglycemia of 16 mg/dl two hours after birth, was subjected to a subtotal pancreatectomy that did not correct hypoglycemia, requiring a total pancreatectomy. Pathological study of the pancreas showed a focal adenomatous hyperplasia. At the present time, she is three years of age and maintains euglycemia with fractionated feeding. A male newborn that had seizures at 28 hours of life and a hypoglycemia of 15 mg/dl was detected. He was also subjected to a subtotal pancreatectomy, that did not correct hypoglycemia and had to be extended to a total pancreatectomy. At the present time, he is 3 years and 11 months of age and has a normal psychomotor development (Rev Méd Chile 2004; 132: 995-1000)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.8 20042004-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000800013es10.4067/S0034-98872004000800013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Endogenous hyperinsulism Hyperinsulism Hypoglicemia
spellingShingle	Endogenous hyperinsulism Hyperinsulism Hypoglicemia Hernández C,M Isabel Hodgson B,M Isabel Cattani O,Andreina Hiperinsulinismo neonatal persistente: Análisis del diagnóstico diferencial a propósito de dos casos clínicos
description	Persistent neonatal hyperinsulinism is the most common cause of refractory hypoglycemia during the first year of life. Inadequate insulin secretion is associated to mutations of four different genes, that can be diagnosed to orient patient management. We report two patients: a female newborn that presented a hypoglycemia of 16 mg/dl two hours after birth, was subjected to a subtotal pancreatectomy that did not correct hypoglycemia, requiring a total pancreatectomy. Pathological study of the pancreas showed a focal adenomatous hyperplasia. At the present time, she is three years of age and maintains euglycemia with fractionated feeding. A male newborn that had seizures at 28 hours of life and a hypoglycemia of 15 mg/dl was detected. He was also subjected to a subtotal pancreatectomy, that did not correct hypoglycemia and had to be extended to a total pancreatectomy. At the present time, he is 3 years and 11 months of age and has a normal psychomotor development (Rev Méd Chile 2004; 132: 995-1000)
author	Hernández C,M Isabel Hodgson B,M Isabel Cattani O,Andreina
author_facet	Hernández C,M Isabel Hodgson B,M Isabel Cattani O,Andreina
author_sort	Hernández C,M Isabel
title	Hiperinsulinismo neonatal persistente: Análisis del diagnóstico diferencial a propósito de dos casos clínicos
title_short	Hiperinsulinismo neonatal persistente: Análisis del diagnóstico diferencial a propósito de dos casos clínicos
title_full	Hiperinsulinismo neonatal persistente: Análisis del diagnóstico diferencial a propósito de dos casos clínicos
title_fullStr	Hiperinsulinismo neonatal persistente: Análisis del diagnóstico diferencial a propósito de dos casos clínicos
title_full_unstemmed	Hiperinsulinismo neonatal persistente: Análisis del diagnóstico diferencial a propósito de dos casos clínicos
title_sort	hiperinsulinismo neonatal persistente: análisis del diagnóstico diferencial a propósito de dos casos clínicos
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000800013
work_keys_str_mv	AT hernandezcmisabel hiperinsulinismoneonatalpersistenteanalisisdeldiagnosticodiferencialapropositodedoscasosclinicos AT hodgsonbmisabel hiperinsulinismoneonatalpersistenteanalisisdeldiagnosticodiferencialapropositodedoscasosclinicos AT cattanioandreina hiperinsulinismoneonatalpersistenteanalisisdeldiagnosticodiferencialapropositodedoscasosclinicos
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Hiperinsulinismo neonatal persistente: Análisis del diagnóstico diferencial a propósito de dos casos clínicos

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