Valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónica

Background: Hyperuricemia has been proposed as a risk marker in chronic heart failure, but its value as an independent prognostic is not well established. Aim: To determine the prognostic value of hyperuricemia, in patients with chronic stable heart failure. Patients and methods: Forty six male pati...

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Autores principales:	Martínez S,Alejandro, González M,Alejandro, Cerda D,Cristián, Pérez C,Pedro, Castro G,Pablo, Pérez P,Osvaldo, Isa P,Rodrigo, Corbalán H,Ramón
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Heart failure congestive Hyperuricemia Stroke volume Ventricular ejection fraction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000900002
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spelling	oai:scielo:S0034-988720040009000022005-11-22Valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónicaMartínez S,AlejandroGonzález M,AlejandroCerda D,CristiánPérez C,PedroCastro G,PabloPérez P,OsvaldoIsa P,RodrigoCorbalán H,Ramón Heart failure congestive Hyperuricemia Stroke volume Ventricular ejection fraction Background: Hyperuricemia has been proposed as a risk marker in chronic heart failure, but its value as an independent prognostic is not well established. Aim: To determine the prognostic value of hyperuricemia, in patients with chronic stable heart failure. Patients and methods: Forty six male patients with chronic heart failure, aged 62±13 years, were studied. Their ejection fraction was less than 40% and their serum creatinine was less than 2 mg/dl. Serum uric acid and catecholamines, maximal oxygen consumption (VO2 max) and left ventricular ejection fraction were measured. Mortality and the need for cardiac transplant were recorded as endpoints during a mean follow up of 39±18 months. The relationship between basal measures and the occurrence of events was analyzed using univariate and multivariate methods. Results: Basal VO2 max and left ventricular ejection fraction were 16±4.6 ml/kg/min and 22±7% respectively. Eighteen patients died and three required transplantation during the follow up. Patients reaching these endpoints had a lower VO2 max and left ventricular ejection fraction and higher uric acid levels. Multivariate analysis accepted left ventricular ejection fraction (relative risk 0.89, 95% CI 0.82-0.97) and serum uric acid (relative risk 1.335 95% CI 1.02-1.74) as significant predictors of events. The relative risk for cardiac transplantation was 7.07 times higher among those with a serum uric acid over 7 mg/dl. Conclusions: A high serum uric acid is an independent predictor of bad prognosis in patients with stable chronic heart failure (Rev Méd Chile 2004; 132: 1031-6info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.9 20042004-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000900002es10.4067/S0034-98872004000900002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Heart failure congestive Hyperuricemia Stroke volume Ventricular ejection fraction
spellingShingle	Heart failure congestive Hyperuricemia Stroke volume Ventricular ejection fraction Martínez S,Alejandro González M,Alejandro Cerda D,Cristián Pérez C,Pedro Castro G,Pablo Pérez P,Osvaldo Isa P,Rodrigo Corbalán H,Ramón Valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónica
description	Background: Hyperuricemia has been proposed as a risk marker in chronic heart failure, but its value as an independent prognostic is not well established. Aim: To determine the prognostic value of hyperuricemia, in patients with chronic stable heart failure. Patients and methods: Forty six male patients with chronic heart failure, aged 62±13 years, were studied. Their ejection fraction was less than 40% and their serum creatinine was less than 2 mg/dl. Serum uric acid and catecholamines, maximal oxygen consumption (VO2 max) and left ventricular ejection fraction were measured. Mortality and the need for cardiac transplant were recorded as endpoints during a mean follow up of 39±18 months. The relationship between basal measures and the occurrence of events was analyzed using univariate and multivariate methods. Results: Basal VO2 max and left ventricular ejection fraction were 16±4.6 ml/kg/min and 22±7% respectively. Eighteen patients died and three required transplantation during the follow up. Patients reaching these endpoints had a lower VO2 max and left ventricular ejection fraction and higher uric acid levels. Multivariate analysis accepted left ventricular ejection fraction (relative risk 0.89, 95% CI 0.82-0.97) and serum uric acid (relative risk 1.335 95% CI 1.02-1.74) as significant predictors of events. The relative risk for cardiac transplantation was 7.07 times higher among those with a serum uric acid over 7 mg/dl. Conclusions: A high serum uric acid is an independent predictor of bad prognosis in patients with stable chronic heart failure (Rev Méd Chile 2004; 132: 1031-6
author	Martínez S,Alejandro González M,Alejandro Cerda D,Cristián Pérez C,Pedro Castro G,Pablo Pérez P,Osvaldo Isa P,Rodrigo Corbalán H,Ramón
author_facet	Martínez S,Alejandro González M,Alejandro Cerda D,Cristián Pérez C,Pedro Castro G,Pablo Pérez P,Osvaldo Isa P,Rodrigo Corbalán H,Ramón
author_sort	Martínez S,Alejandro
title	Valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónica
title_short	Valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónica
title_full	Valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónica
title_fullStr	Valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónica
title_full_unstemmed	Valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónica
title_sort	valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónica
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000900002
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Valor pronóstico de la hiperuricemia en la insuficiencia cardíaca crónica

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