Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentos

Background: Shiga toxin-producing E coli (STEC) are zoonotic pathogens associated to sporadic episodes of bloody diarrhea, foodborne outbreaks, and Hemolytic Uremic Syndrome (HUS), with worldwide public health impact. Antibiotic use in STEC infections is controversial because of the potential to inc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Reyes S,Marcelo, Durán T,Claudia, Prado J,Valeria
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Escherichia coli O157 Hemolytic-uremic syndrome Shiga toxin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001000008
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872004001000008
record_format	dspace
spelling	oai:scielo:S0034-988720040010000082004-12-15Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentosReyes S,MarceloDurán T,ClaudiaPrado J,Valeria Escherichia coli O157 Hemolytic-uremic syndrome Shiga toxin Background: Shiga toxin-producing E coli (STEC) are zoonotic pathogens associated to sporadic episodes of bloody diarrhea, foodborne outbreaks, and Hemolytic Uremic Syndrome (HUS), with worldwide public health impact. Antibiotic use in STEC infections is controversial because of the potential to increase production and secretion of Shiga toxins. Aim: To study the in vitro antimicrobial susceptibility profile of STEC. Material and methods: The in vitro susceptibility profile against 10 antimicrobials of STEC strains isolated from 29 meat products, 20 patients with diarrhea and 9 HUS patients was studied. Minimal Inhibitory Concentrations (µg/ml) by agar dilution method for ampicillin, cloramphenicol, ciprofloxacin, amikacin, gentamycin, cotrimoxazol, ceftriaxone, tetracycline, fosfomycin and azithromycin were measured according to NCCLS recommendations. Results: Strains from patients with diarrhea or HUS were all susceptible to the 10 antimicrobials and only 13.7% had intermediate resistance to cloramphenicol. Strains from meat products had a similar susceptibility profile, with only 3.5% resistance to tetracycline, 3.5% intermediate resistance to cloramphenicol and 7% to fosfomycin. All 58 strains were considered resistant to azithromycin (MIC >32 ug/ml). Conclusions: Similarity of susceptibility profiles between STEC strains from human and food origin suggests a role of food chain in transmission to humans (Rev Méd Chile 2004; 132: 1211-6)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.10 20042004-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001000008es10.4067/S0034-98872004001000008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Escherichia coli O157 Hemolytic-uremic syndrome Shiga toxin
spellingShingle	Escherichia coli O157 Hemolytic-uremic syndrome Shiga toxin Reyes S,Marcelo Durán T,Claudia Prado J,Valeria Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentos
description	Background: Shiga toxin-producing E coli (STEC) are zoonotic pathogens associated to sporadic episodes of bloody diarrhea, foodborne outbreaks, and Hemolytic Uremic Syndrome (HUS), with worldwide public health impact. Antibiotic use in STEC infections is controversial because of the potential to increase production and secretion of Shiga toxins. Aim: To study the in vitro antimicrobial susceptibility profile of STEC. Material and methods: The in vitro susceptibility profile against 10 antimicrobials of STEC strains isolated from 29 meat products, 20 patients with diarrhea and 9 HUS patients was studied. Minimal Inhibitory Concentrations (µg/ml) by agar dilution method for ampicillin, cloramphenicol, ciprofloxacin, amikacin, gentamycin, cotrimoxazol, ceftriaxone, tetracycline, fosfomycin and azithromycin were measured according to NCCLS recommendations. Results: Strains from patients with diarrhea or HUS were all susceptible to the 10 antimicrobials and only 13.7% had intermediate resistance to cloramphenicol. Strains from meat products had a similar susceptibility profile, with only 3.5% resistance to tetracycline, 3.5% intermediate resistance to cloramphenicol and 7% to fosfomycin. All 58 strains were considered resistant to azithromycin (MIC >32 ug/ml). Conclusions: Similarity of susceptibility profiles between STEC strains from human and food origin suggests a role of food chain in transmission to humans (Rev Méd Chile 2004; 132: 1211-6)
author	Reyes S,Marcelo Durán T,Claudia Prado J,Valeria
author_facet	Reyes S,Marcelo Durán T,Claudia Prado J,Valeria
author_sort	Reyes S,Marcelo
title	Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentos
title_short	Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentos
title_full	Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentos
title_fullStr	Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentos
title_full_unstemmed	Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentos
title_sort	perfil de susceptibilidad a los antimicrobianos en cepas de e coli productoras de shiga toxina (stec) aisladas de infecciones humanas y de alimentos
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001000008
work_keys_str_mv	AT reyessmarcelo perfildesusceptibilidadalosantimicrobianosencepasdeecoliproductorasdeshigatoxinastecaisladasdeinfeccioneshumanasydealimentos AT durantclaudia perfildesusceptibilidadalosantimicrobianosencepasdeecoliproductorasdeshigatoxinastecaisladasdeinfeccioneshumanasydealimentos AT pradojvaleria perfildesusceptibilidadalosantimicrobianosencepasdeecoliproductorasdeshigatoxinastecaisladasdeinfeccioneshumanasydealimentos
_version_	1718436172293734400

Perfil de susceptibilidad a los antimicrobianos en cepas de E coli productoras de Shiga toxina (STEC) aisladas de infecciones humanas y de alimentos

Ejemplares similares