Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos

Background: Subacute combined degeneration is a clinical manifestation of vitamin B12 deficiency, that we observe with unusual frequency. Aim: To report a series of eleven patients with subacute combined degeneration. Patients and methods: Retrospective analysis of 11 patients hospitalized in a publ...

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Autores principales:	Nogales-Gaete,Jorge, Jiménez P,Paula, García F,Pía, Sáez M,David, Aracena C,Rodrigo, González V,Jorge, Lay-Son R,Luis, Tenhamm F,Eugenio, Figueroa R,Tatiana, Chávez M,Andrea, Oelker B,Carolina, Vega M,Luis
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Myelitis Spinal cord diseases Vitamin B12
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001100006
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spelling	oai:scielo:S0034-988720040011000062005-01-12Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casosNogales-Gaete,JorgeJiménez P,PaulaGarcía F,PíaSáez M,DavidAracena C,RodrigoGonzález V,JorgeLay-Son R,LuisTenhamm F,EugenioFigueroa R,TatianaChávez M,AndreaOelker B,CarolinaVega M,Luis Myelitis Spinal cord diseases Vitamin B12 Background: Subacute combined degeneration is a clinical manifestation of vitamin B12 deficiency, that we observe with unusual frequency. Aim: To report a series of eleven patients with subacute combined degeneration. Patients and methods: Retrospective analysis of 11 patients hospitalized in a public hospital in Santiago, between March 2001 and February 2003. All had a myelopathy of more than three weeks of evolution with serum vitamin B12 levels of less than 200 pg/ml. Results: A risk factor was identified in 10 cases and the most common was an age over 60 years old. The main presenting symptom was the presence of paresthesias. On admission, sphincter dysfunction, posterior column and pyramidal syndromes coexisted in nine patients. A level of sensitive deficit was detected in six. Ten patients had macrocytosis and eight were anemic. Serum vitamin B12 was measured in ten and in nine, it was below 200 pg/ml. The mean lapse between onset of symptoms and treatment was eight months. All received intramuscular vitamin B12 in doses on 1,000 to 10,000 IU/day. Sphincter dysfunction and propioception were the first symptoms to improve. Conclusions: Subacute combined degeneration must be suspected in patients older than 60 years with a subacute myelopathic syndrome and low serum vitamin B12 levelsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.11 20042004-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001100006es10.4067/S0034-98872004001100006
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Myelitis Spinal cord diseases Vitamin B12
spellingShingle	Myelitis Spinal cord diseases Vitamin B12 Nogales-Gaete,Jorge Jiménez P,Paula García F,Pía Sáez M,David Aracena C,Rodrigo González V,Jorge Lay-Son R,Luis Tenhamm F,Eugenio Figueroa R,Tatiana Chávez M,Andrea Oelker B,Carolina Vega M,Luis Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos
description	Background: Subacute combined degeneration is a clinical manifestation of vitamin B12 deficiency, that we observe with unusual frequency. Aim: To report a series of eleven patients with subacute combined degeneration. Patients and methods: Retrospective analysis of 11 patients hospitalized in a public hospital in Santiago, between March 2001 and February 2003. All had a myelopathy of more than three weeks of evolution with serum vitamin B12 levels of less than 200 pg/ml. Results: A risk factor was identified in 10 cases and the most common was an age over 60 years old. The main presenting symptom was the presence of paresthesias. On admission, sphincter dysfunction, posterior column and pyramidal syndromes coexisted in nine patients. A level of sensitive deficit was detected in six. Ten patients had macrocytosis and eight were anemic. Serum vitamin B12 was measured in ten and in nine, it was below 200 pg/ml. The mean lapse between onset of symptoms and treatment was eight months. All received intramuscular vitamin B12 in doses on 1,000 to 10,000 IU/day. Sphincter dysfunction and propioception were the first symptoms to improve. Conclusions: Subacute combined degeneration must be suspected in patients older than 60 years with a subacute myelopathic syndrome and low serum vitamin B12 levels
author	Nogales-Gaete,Jorge Jiménez P,Paula García F,Pía Sáez M,David Aracena C,Rodrigo González V,Jorge Lay-Son R,Luis Tenhamm F,Eugenio Figueroa R,Tatiana Chávez M,Andrea Oelker B,Carolina Vega M,Luis
author_facet	Nogales-Gaete,Jorge Jiménez P,Paula García F,Pía Sáez M,David Aracena C,Rodrigo González V,Jorge Lay-Son R,Luis Tenhamm F,Eugenio Figueroa R,Tatiana Chávez M,Andrea Oelker B,Carolina Vega M,Luis
author_sort	Nogales-Gaete,Jorge
title	Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos
title_short	Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos
title_full	Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos
title_fullStr	Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos
title_full_unstemmed	Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos
title_sort	mielopatía por déficit de vitamina b12: caracterización clínica de 11 casos
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001100006
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Mielopatía por déficit de vitamina B12: caracterización clínica de 11 casos

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