Trastornos del ánimo, psicofármacos y tiroides

For more than 40 years thyroid hormones and mood disorders have been associated. Some psychiatric symptoms are produced by thyroid illnesses and there is a frequent association of thyroid dysfunction with mood disorders. Therefore, routine thyroid function assessment in patients with mood disorders...

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Autores principales:	Quiroz L,Danilo, Gloger K,Sergio, Valdivieso F,Sergio, Ivelic Z,José, Fardella B,Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2004
Materias:	Mood disorders Psychopharmacology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001100012
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spelling	oai:scielo:S0034-988720040011000122005-01-12Trastornos del ánimo, psicofármacos y tiroidesQuiroz L,DaniloGloger K,SergioValdivieso F,SergioIvelic Z,JoséFardella B,Carlos Mood disorders Psychopharmacology For more than 40 years thyroid hormones and mood disorders have been associated. Some psychiatric symptoms are produced by thyroid illnesses and there is a frequent association of thyroid dysfunction with mood disorders. Therefore, routine thyroid function assessment in patients with mood disorders and the treatment of sub-clinical thyroid dysfunctions is recommended. The usefulness of adding thyroid hormones to antidepressive treatment in euthyroid patients to obtain a potentiation effect has been probed repeatedly. The most common strategy is potentiation with T3, but high doses of T4 have been also used in patients with resistant depression. Thyroid hormones exert their action in the central nervous system through a variety of mechanisms: modulation of gene expression of several groups of proteins, some of them with known physiopathological implications in mood disorders and the influence over serotonin and noradrenergic neurotransmission, known to be one of the modes of action of antidepressants. Finally, it is also important to stress the complex relationship between psychiatric drugs, deiodinases and thyroid hormones, that can potentially help to understand the mechanisms of action of these drugsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.11 20042004-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001100012es10.4067/S0034-98872004001100012
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Mood disorders Psychopharmacology
spellingShingle	Mood disorders Psychopharmacology Quiroz L,Danilo Gloger K,Sergio Valdivieso F,Sergio Ivelic Z,José Fardella B,Carlos Trastornos del ánimo, psicofármacos y tiroides
description	For more than 40 years thyroid hormones and mood disorders have been associated. Some psychiatric symptoms are produced by thyroid illnesses and there is a frequent association of thyroid dysfunction with mood disorders. Therefore, routine thyroid function assessment in patients with mood disorders and the treatment of sub-clinical thyroid dysfunctions is recommended. The usefulness of adding thyroid hormones to antidepressive treatment in euthyroid patients to obtain a potentiation effect has been probed repeatedly. The most common strategy is potentiation with T3, but high doses of T4 have been also used in patients with resistant depression. Thyroid hormones exert their action in the central nervous system through a variety of mechanisms: modulation of gene expression of several groups of proteins, some of them with known physiopathological implications in mood disorders and the influence over serotonin and noradrenergic neurotransmission, known to be one of the modes of action of antidepressants. Finally, it is also important to stress the complex relationship between psychiatric drugs, deiodinases and thyroid hormones, that can potentially help to understand the mechanisms of action of these drugs
author	Quiroz L,Danilo Gloger K,Sergio Valdivieso F,Sergio Ivelic Z,José Fardella B,Carlos
author_facet	Quiroz L,Danilo Gloger K,Sergio Valdivieso F,Sergio Ivelic Z,José Fardella B,Carlos
author_sort	Quiroz L,Danilo
title	Trastornos del ánimo, psicofármacos y tiroides
title_short	Trastornos del ánimo, psicofármacos y tiroides
title_full	Trastornos del ánimo, psicofármacos y tiroides
title_fullStr	Trastornos del ánimo, psicofármacos y tiroides
title_full_unstemmed	Trastornos del ánimo, psicofármacos y tiroides
title_sort	trastornos del ánimo, psicofármacos y tiroides
publisher	Sociedad Médica de Santiago
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001100012
work_keys_str_mv	AT quirozldanilo trastornosdelanimopsicofarmacosytiroides AT glogerksergio trastornosdelanimopsicofarmacosytiroides AT valdiviesofsergio trastornosdelanimopsicofarmacosytiroides AT iveliczjose trastornosdelanimopsicofarmacosytiroides AT fardellabcarlos trastornosdelanimopsicofarmacosytiroides
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Trastornos del ánimo, psicofármacos y tiroides

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