Análisis crítico de un artículo: Critical appraisal: Band ligation and propranolol are equally effective for primary prevention of variceal bleeding. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W et al; German Study Group for the Primary Prophylaxis of Variceal Bleeding. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72.
In this randomized controlled multicenter trial, we compared endoscopic variceal banding ligation (VBL) with propranolol (PPL) for primary prophylaxis of variceal bleeding. One hundred fifty-two cirrhotic patients with 2 or more esophageal varices (diameter >5 mm) without prior bleeding were rand...
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2004
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oai:scielo:S0034-988720040012000172006-03-21Análisis crítico de un artículo: Critical appraisal: Band ligation and propranolol are equally effective for primary prevention of variceal bleeding. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W et al; German Study Group for the Primary Prophylaxis of Variceal Bleeding. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72.Larrondo G,Francisco JavierManríquez M,Juan JorgeIn this randomized controlled multicenter trial, we compared endoscopic variceal banding ligation (VBL) with propranolol (PPL) for primary prophylaxis of variceal bleeding. One hundred fifty-two cirrhotic patients with 2 or more esophageal varices (diameter >5 mm) without prior bleeding were randomized to VBL (n=75) or PPL (n=77). The groups were well matched with respect to baseline characteristics (age 56±10 years, alcoholic etiology 51%, Child-Pugh score 7.2±1.8). The mean follow-up was 34±19 months. Data were analyzed on an intention-to-treat basis. Neither bleeding incidence nor mortality differed significantly between the 2 groups. Variceal bleeding occurred in 25% of the VBL group and in 29% of the PPL group. The actuarial risks of bleeding after 2 years were 20% (VBL) and 18% (PPL). Fatal bleeding was observed in 12% (VBL) and 10% (PPL). It was associated with the ligation procedure in 2 patients (2.6%). Overall mortality was 45% (VBL) and 43% (PPL) with the 2-year actuarial risks being 28% (VBL) and 22% (PPL). 25% of patients withdrew from PPL treatment, 16% due to side effects. In conclusion, VBL and PPL were similarly effective for primary prophylaxis of variceal bleeding. VBL should be offered to patients who are not candidates for long-term PPL treatmentinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.132 n.12 20042004-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001200017es10.4067/S0034-98872004001200017 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| description |
In this randomized controlled multicenter trial, we compared endoscopic variceal banding ligation (VBL) with propranolol (PPL) for primary prophylaxis of variceal bleeding. One hundred fifty-two cirrhotic patients with 2 or more esophageal varices (diameter >5 mm) without prior bleeding were randomized to VBL (n=75) or PPL (n=77). The groups were well matched with respect to baseline characteristics (age 56±10 years, alcoholic etiology 51%, Child-Pugh score 7.2±1.8). The mean follow-up was 34±19 months. Data were analyzed on an intention-to-treat basis. Neither bleeding incidence nor mortality differed significantly between the 2 groups. Variceal bleeding occurred in 25% of the VBL group and in 29% of the PPL group. The actuarial risks of bleeding after 2 years were 20% (VBL) and 18% (PPL). Fatal bleeding was observed in 12% (VBL) and 10% (PPL). It was associated with the ligation procedure in 2 patients (2.6%). Overall mortality was 45% (VBL) and 43% (PPL) with the 2-year actuarial risks being 28% (VBL) and 22% (PPL). 25% of patients withdrew from PPL treatment, 16% due to side effects. In conclusion, VBL and PPL were similarly effective for primary prophylaxis of variceal bleeding. VBL should be offered to patients who are not candidates for long-term PPL treatment |
| author |
Larrondo G,Francisco Javier Manríquez M,Juan Jorge |
| spellingShingle |
Larrondo G,Francisco Javier Manríquez M,Juan Jorge Análisis crítico de un artículo: Critical appraisal: Band ligation and propranolol are equally effective for primary prevention of variceal bleeding. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W et al; German Study Group for the Primary Prophylaxis of Variceal Bleeding. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72. |
| author_facet |
Larrondo G,Francisco Javier Manríquez M,Juan Jorge |
| author_sort |
Larrondo G,Francisco Javier |
| title |
Análisis crítico de un artículo: Critical appraisal: Band ligation and propranolol are equally effective for primary prevention of variceal bleeding. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W et al; German Study Group for the Primary Prophylaxis of Variceal Bleeding. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72. |
| title_short |
Análisis crítico de un artículo: Critical appraisal: Band ligation and propranolol are equally effective for primary prevention of variceal bleeding. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W et al; German Study Group for the Primary Prophylaxis of Variceal Bleeding. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72. |
| title_full |
Análisis crítico de un artículo: Critical appraisal: Band ligation and propranolol are equally effective for primary prevention of variceal bleeding. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W et al; German Study Group for the Primary Prophylaxis of Variceal Bleeding. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72. |
| title_fullStr |
Análisis crítico de un artículo: Critical appraisal: Band ligation and propranolol are equally effective for primary prevention of variceal bleeding. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W et al; German Study Group for the Primary Prophylaxis of Variceal Bleeding. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72. |
| title_full_unstemmed |
Análisis crítico de un artículo: Critical appraisal: Band ligation and propranolol are equally effective for primary prevention of variceal bleeding. Schepke M, Kleber G, Nurnberg D, Willert J, Koch L, Veltzke-Schlieker W et al; German Study Group for the Primary Prophylaxis of Variceal Bleeding. Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2004; 40: 65-72. |
| title_sort |
análisis crítico de un artículo: critical appraisal: band ligation and propranolol are equally effective for primary prevention of variceal bleeding. schepke m, kleber g, nurnberg d, willert j, koch l, veltzke-schlieker w et al; german study group for the primary prophylaxis of variceal bleeding. ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis. hepatology 2004; 40: 65-72. |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2004 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001200017 |
| work_keys_str_mv |
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