Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003

Background: In Chile, the emergence of drug-resistant strains of Streptococcus pneumoniae has complicated treatment decisions and may lead to treatment failures. Aim: to examine antimicrobial resistance trends among pneumococcal isolates from the Catholic University Hospital between 1997 and 2003. M...

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Autores principales:	Saldías P,Fernando, Flores S,Luis José, Torres M,Catalina, García C,Patricia, Díaz F,Alejandro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Drug resistance, bacterial Pneumococcal infections Streptococcus pneumoniae
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000100006
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spelling	oai:scielo:S0034-988720050001000062014-08-12Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003Saldías P,FernandoFlores S,Luis JoséTorres M,CatalinaGarcía C,PatriciaDíaz F,Alejandro Drug resistance, bacterial Pneumococcal infections Streptococcus pneumoniae Background: In Chile, the emergence of drug-resistant strains of Streptococcus pneumoniae has complicated treatment decisions and may lead to treatment failures. Aim: to examine antimicrobial resistance trends among pneumococcal isolates from the Catholic University Hospital between 1997 and 2003. Material and methods: During a seven-year period, we examined 901 strains of S. pneumoniae isolated from sterile and non-sterile samples from adult and pediatric population. Results: Overall, 20% of isolates showed intermediate resistance to penicillin (MIC: 0.12-1 µg/ml) y 10.8% high level of resistance to penicillin (MIC <FONT FACE=Symbol>³</FONT> 2 µg/ml). Pneumococcal resistance to penicillin did not change significantly during the study period, but it was more common in pediatric patients and isolates from non-sterile samples. No isolate had a MIC <FONT FACE=Symbol>³</FONT> 8 µg/ml for penicillin. Twenty one percent of pneumococcal strains were resistant to erythromycin, 41.6% to trimethoprim-sulfamethoxazole and 3.6% to chloramphenicol. Macrolides resistance tended to increase between 1997 and 2003. Fourteen percent of strains showed intermediate resistance (MIC: 1 µg/ml) and 2.5%, a high level of resistance to cefotaxime (MIC: <FONT FACE=Symbol>³</FONT> 2 µg/ml). No isolate had a CIM <FONT FACE=Symbol>³</FONT> 4 µg/ml for cefotaxime. Among those isolates with intermediate or high level of resistance to penicillin, there were significantly more isolates highly resistant to erythromycin, trimethoprim-sulfamethoxazole and cefotaxime. Conclusions: Multidrug-resistant pneumococci are common and are increasing in our country, particularly in pediatric population, probably associated to indiscriminate ambulatory prescription of antimicrobials (Rev Méd Chile 2005; 133: 42-49)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.1 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000100006es10.4067/S0034-98872005000100006
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Drug resistance, bacterial Pneumococcal infections Streptococcus pneumoniae
spellingShingle	Drug resistance, bacterial Pneumococcal infections Streptococcus pneumoniae Saldías P,Fernando Flores S,Luis José Torres M,Catalina García C,Patricia Díaz F,Alejandro Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003
description	Background: In Chile, the emergence of drug-resistant strains of Streptococcus pneumoniae has complicated treatment decisions and may lead to treatment failures. Aim: to examine antimicrobial resistance trends among pneumococcal isolates from the Catholic University Hospital between 1997 and 2003. Material and methods: During a seven-year period, we examined 901 strains of S. pneumoniae isolated from sterile and non-sterile samples from adult and pediatric population. Results: Overall, 20% of isolates showed intermediate resistance to penicillin (MIC: 0.12-1 µg/ml) y 10.8% high level of resistance to penicillin (MIC <FONT FACE=Symbol>³</FONT> 2 µg/ml). Pneumococcal resistance to penicillin did not change significantly during the study period, but it was more common in pediatric patients and isolates from non-sterile samples. No isolate had a MIC <FONT FACE=Symbol>³</FONT> 8 µg/ml for penicillin. Twenty one percent of pneumococcal strains were resistant to erythromycin, 41.6% to trimethoprim-sulfamethoxazole and 3.6% to chloramphenicol. Macrolides resistance tended to increase between 1997 and 2003. Fourteen percent of strains showed intermediate resistance (MIC: 1 µg/ml) and 2.5%, a high level of resistance to cefotaxime (MIC: <FONT FACE=Symbol>³</FONT> 2 µg/ml). No isolate had a CIM <FONT FACE=Symbol>³</FONT> 4 µg/ml for cefotaxime. Among those isolates with intermediate or high level of resistance to penicillin, there were significantly more isolates highly resistant to erythromycin, trimethoprim-sulfamethoxazole and cefotaxime. Conclusions: Multidrug-resistant pneumococci are common and are increasing in our country, particularly in pediatric population, probably associated to indiscriminate ambulatory prescription of antimicrobials (Rev Méd Chile 2005; 133: 42-49)
author	Saldías P,Fernando Flores S,Luis José Torres M,Catalina García C,Patricia Díaz F,Alejandro
author_facet	Saldías P,Fernando Flores S,Luis José Torres M,Catalina García C,Patricia Díaz F,Alejandro
author_sort	Saldías P,Fernando
title	Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003
title_short	Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003
title_full	Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003
title_fullStr	Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003
title_full_unstemmed	Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003
title_sort	susceptibilidad a antimicrobianos de streptococcus pneumoniae en poblacion infantil y adulta de santiago: periodo 1997-2003
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000100006
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Susceptibilidad a antimicrobianos de Streptococcus pneumoniae en poblacion infantil y adulta de Santiago: Periodo 1997-2003

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