Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia

Background: Recent evidence from birth order data suggest that maternal factors can differently influence anencephaly and spina bifida. Aim: To study the influence of maternal age on the risk for neural tube defects. Material and methods: A meta-analysis of published data on neural tube defects (NTD...

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Autores principales:	Vieira,Alexandre R., Castillo Taucher,Silvia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Anencephaly Maternal age Neural tube defects Spinal dysraphism
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000100008
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spelling	oai:scielo:S0034-988720050001000082014-08-12Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefaliaVieira,Alexandre R.Castillo Taucher,Silvia Anencephaly Maternal age Neural tube defects Spinal dysraphism Background: Recent evidence from birth order data suggest that maternal factors can differently influence anencephaly and spina bifida. Aim: To study the influence of maternal age on the risk for neural tube defects. Material and methods: A meta-analysis of published data on neural tube defects (NTDs) was carried out to determine whether there is an increased risk to have a child with NTDs for younger and older mothers and if this risk differs depending on the type of NTD. All data available with information regarding the frequency of live births and NTDs cases by maternal age (five- or ten-year intervals) were included in the analysis. Effect sizes calculations were performed. Results: The analysis supports the hypothesis that there is an increased risk of having an offspring with NTDs for mothers 40 years of age or older. However, this effect is stronger for spina bifida than for anencephaly. There is also evidence that mothers 19 years old or younger have a higher risk for having a child with spina bifida. Conclusions: Maternal age influences the risk of having an offspring with neural tube defects (Rev Méd Chile 2005; 133: 62-70)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.1 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000100008es10.4067/S0034-98872005000100008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Anencephaly Maternal age Neural tube defects Spinal dysraphism
spellingShingle	Anencephaly Maternal age Neural tube defects Spinal dysraphism Vieira,Alexandre R. Castillo Taucher,Silvia Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia
description	Background: Recent evidence from birth order data suggest that maternal factors can differently influence anencephaly and spina bifida. Aim: To study the influence of maternal age on the risk for neural tube defects. Material and methods: A meta-analysis of published data on neural tube defects (NTDs) was carried out to determine whether there is an increased risk to have a child with NTDs for younger and older mothers and if this risk differs depending on the type of NTD. All data available with information regarding the frequency of live births and NTDs cases by maternal age (five- or ten-year intervals) were included in the analysis. Effect sizes calculations were performed. Results: The analysis supports the hypothesis that there is an increased risk of having an offspring with NTDs for mothers 40 years of age or older. However, this effect is stronger for spina bifida than for anencephaly. There is also evidence that mothers 19 years old or younger have a higher risk for having a child with spina bifida. Conclusions: Maternal age influences the risk of having an offspring with neural tube defects (Rev Méd Chile 2005; 133: 62-70)
author	Vieira,Alexandre R. Castillo Taucher,Silvia
author_facet	Vieira,Alexandre R. Castillo Taucher,Silvia
author_sort	Vieira,Alexandre R.
title	Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia
title_short	Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia
title_full	Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia
title_fullStr	Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia
title_full_unstemmed	Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia
title_sort	edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000100008
work_keys_str_mv	AT vieiraalexandrer edadmaternaydefectosdeltuboneuralevidenciaparaunefectomayorenespinabifidaqueanencefalia AT castillotauchersilvia edadmaternaydefectosdeltuboneuralevidenciaparaunefectomayorenespinabifidaqueanencefalia
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Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia

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