Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literatura

There is a strong association between low birth weight and insulin resistance. The thrifty phenotype hypothesis, which postulates fetal programming for adaptation to an adverse intrauterine environment, resulting in a lower insulin sensitivity in utero, is one of the hypothesis to explain this assoc...

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Autores principales:	Soto I,Néstor, Mericq G,Verónica
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Fetal growth retardation Insulin resistance Metabolic syndrome X
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000100013
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spelling	oai:scielo:S0034-988720050001000132014-08-12Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literaturaSoto I,NéstorMericq G,Verónica Fetal growth retardation Insulin resistance Metabolic syndrome X There is a strong association between low birth weight and insulin resistance. The thrifty phenotype hypothesis, which postulates fetal programming for adaptation to an adverse intrauterine environment, resulting in a lower insulin sensitivity in utero, is one of the hypothesis to explain this association. Later in life, syndrome X may develop, featuring hypertension, dyslipidemia, central obesity and type 2 diabetes, associated to an excessive food intake. Our investigation during the first three years of life in a prospective cohort of small (SGA) or appropriate for gestational age newborns, demonstrated that a significant increase of insulin levels is detected in SGA, as early as during the first year of life, but only when catch up growth (CUG) occurs. Orexigenic peptides such as Ghrelin appear to participate in this CUG phenomenon. We also sought to determine whether these associations were observed in individuals born with very low birth weight. We found that in utero as well as postnatal growth rates were independent determinants of insulin sensitivity and secretion. Education about feeding practices and physical activity in SGA children, is a future challenge to prevent the onset of syndrome X in this predisposed population (Rev Méd Chile 2005; 133: 97-104info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.1 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000100013es10.4067/S0034-98872005000100013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Fetal growth retardation Insulin resistance Metabolic syndrome X
spellingShingle	Fetal growth retardation Insulin resistance Metabolic syndrome X Soto I,Néstor Mericq G,Verónica Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literatura
description	There is a strong association between low birth weight and insulin resistance. The thrifty phenotype hypothesis, which postulates fetal programming for adaptation to an adverse intrauterine environment, resulting in a lower insulin sensitivity in utero, is one of the hypothesis to explain this association. Later in life, syndrome X may develop, featuring hypertension, dyslipidemia, central obesity and type 2 diabetes, associated to an excessive food intake. Our investigation during the first three years of life in a prospective cohort of small (SGA) or appropriate for gestational age newborns, demonstrated that a significant increase of insulin levels is detected in SGA, as early as during the first year of life, but only when catch up growth (CUG) occurs. Orexigenic peptides such as Ghrelin appear to participate in this CUG phenomenon. We also sought to determine whether these associations were observed in individuals born with very low birth weight. We found that in utero as well as postnatal growth rates were independent determinants of insulin sensitivity and secretion. Education about feeding practices and physical activity in SGA children, is a future challenge to prevent the onset of syndrome X in this predisposed population (Rev Méd Chile 2005; 133: 97-104
author	Soto I,Néstor Mericq G,Verónica
author_facet	Soto I,Néstor Mericq G,Verónica
author_sort	Soto I,Néstor
title	Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literatura
title_short	Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literatura
title_full	Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literatura
title_fullStr	Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literatura
title_full_unstemmed	Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literatura
title_sort	restricción del crecimiento fetal e insulinorresistencia: nuevos hallazgos y revisión de la literatura
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000100013
work_keys_str_mv	AT sotoinestor restricciondelcrecimientofetaleinsulinorresistencianuevoshallazgosyrevisiondelaliteratura AT mericqgveronica restricciondelcrecimientofetaleinsulinorresistencianuevoshallazgosyrevisiondelaliteratura
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Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literatura

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