Anticuerpos antifosfolípidos en nefropatía membranosa idiopática

Background: Antiphospholipid antibodies have been found in the sera from patients with idiopathic and secondary glomerulopathies, mainly related to lupus. No special attention has been devoted to idiopathic membranous nephropathy, a glomerular disease with a high frequency of thrombotic complication...

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Autores principales:	Ardiles A,Leopoldo, Blackburn T,Eileen, Alruiz S,Paula, Flores W,Claudio, Mezzano A,Sergio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Antibodies, anticardiolipin Antibodies, antiphospholipid Beta 2-glycoprotein I Glomerulonephritis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000300003
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spelling	oai:scielo:S0034-988720050003000032005-05-17Anticuerpos antifosfolípidos en nefropatía membranosa idiopáticaArdiles A,LeopoldoBlackburn T,EileenAlruiz S,PaulaFlores W,ClaudioMezzano A,Sergio Antibodies, anticardiolipin Antibodies, antiphospholipid Beta 2-glycoprotein I Glomerulonephritis Background: Antiphospholipid antibodies have been found in the sera from patients with idiopathic and secondary glomerulopathies, mainly related to lupus. No special attention has been devoted to idiopathic membranous nephropathy, a glomerular disease with a high frequency of thrombotic complications, particularly of the renal vein. Aim: To study the presence and significance of antiphospholipid antibodies in idiopathic membranous nephropathy. Material and methods: Anticardiolipin and anti-ß2-glycoprotein-I IgG antibodies were measured in serum samples from 21 patients with idiopathic membranous nephropathy (age range 11-75 years, 5 female). The medical records of 20 of these patients were reviewed, looking for vascular complications and nephrological evolution during a follow-up period that ranged from two to 277 months. Results: Five patients had anticardiolipin antibody titers over the cutoff for normal values, and two others were positive for anti-ß2-glycoprotein-I, without cross-reactivity. There was no difference in the incidence of thrombotic complications in the renal vein, or other locations, between these seven patients and the remaining patients. No differences in the clinical course of the nephropathy were detected either. Conclusions: Antiphospholipid antibodies may be found in patients with primary membranous nephropathy. They are not related to thrombosis or a worse evolution (Rev Méd Chile 2005; 133: 287-93)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.3 20052005-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000300003es10.4067/S0034-98872005000300003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antibodies, anticardiolipin Antibodies, antiphospholipid Beta 2-glycoprotein I Glomerulonephritis
spellingShingle	Antibodies, anticardiolipin Antibodies, antiphospholipid Beta 2-glycoprotein I Glomerulonephritis Ardiles A,Leopoldo Blackburn T,Eileen Alruiz S,Paula Flores W,Claudio Mezzano A,Sergio Anticuerpos antifosfolípidos en nefropatía membranosa idiopática
description	Background: Antiphospholipid antibodies have been found in the sera from patients with idiopathic and secondary glomerulopathies, mainly related to lupus. No special attention has been devoted to idiopathic membranous nephropathy, a glomerular disease with a high frequency of thrombotic complications, particularly of the renal vein. Aim: To study the presence and significance of antiphospholipid antibodies in idiopathic membranous nephropathy. Material and methods: Anticardiolipin and anti-ß2-glycoprotein-I IgG antibodies were measured in serum samples from 21 patients with idiopathic membranous nephropathy (age range 11-75 years, 5 female). The medical records of 20 of these patients were reviewed, looking for vascular complications and nephrological evolution during a follow-up period that ranged from two to 277 months. Results: Five patients had anticardiolipin antibody titers over the cutoff for normal values, and two others were positive for anti-ß2-glycoprotein-I, without cross-reactivity. There was no difference in the incidence of thrombotic complications in the renal vein, or other locations, between these seven patients and the remaining patients. No differences in the clinical course of the nephropathy were detected either. Conclusions: Antiphospholipid antibodies may be found in patients with primary membranous nephropathy. They are not related to thrombosis or a worse evolution (Rev Méd Chile 2005; 133: 287-93)
author	Ardiles A,Leopoldo Blackburn T,Eileen Alruiz S,Paula Flores W,Claudio Mezzano A,Sergio
author_facet	Ardiles A,Leopoldo Blackburn T,Eileen Alruiz S,Paula Flores W,Claudio Mezzano A,Sergio
author_sort	Ardiles A,Leopoldo
title	Anticuerpos antifosfolípidos en nefropatía membranosa idiopática
title_short	Anticuerpos antifosfolípidos en nefropatía membranosa idiopática
title_full	Anticuerpos antifosfolípidos en nefropatía membranosa idiopática
title_fullStr	Anticuerpos antifosfolípidos en nefropatía membranosa idiopática
title_full_unstemmed	Anticuerpos antifosfolípidos en nefropatía membranosa idiopática
title_sort	anticuerpos antifosfolípidos en nefropatía membranosa idiopática
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000300003
work_keys_str_mv	AT ardilesaleopoldo anticuerposantifosfolipidosennefropatiamembranosaidiopatica AT blackburnteileen anticuerposantifosfolipidosennefropatiamembranosaidiopatica AT alruizspaula anticuerposantifosfolipidosennefropatiamembranosaidiopatica AT floreswclaudio anticuerposantifosfolipidosennefropatiamembranosaidiopatica AT mezzanoasergio anticuerposantifosfolipidosennefropatiamembranosaidiopatica
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Anticuerpos antifosfolípidos en nefropatía membranosa idiopática

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