Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección

Chronic kidney disease is a worldwide health problem. The incidence and prevalence of kidney failure is in constant increase, involving poor outcomes and high costs. The leading causes of kidney failure are type 2 diabetes and hypertension. The new initiative "Kidney Disease Improving Global Ou...

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Autores principales:	Mezzano A,Sergio, Aros E,Claudio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Diabetic nephropathy Glomerular filtration rate Kidney diseases Kidney failure Proteinuria
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000300011
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spelling	oai:scielo:S0034-988720050003000112005-05-17Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotecciónMezzano A,SergioAros E,Claudio Diabetic nephropathy Glomerular filtration rate Kidney diseases Kidney failure Proteinuria Chronic kidney disease is a worldwide health problem. The incidence and prevalence of kidney failure is in constant increase, involving poor outcomes and high costs. The leading causes of kidney failure are type 2 diabetes and hypertension. The new initiative "Kidney Disease Improving Global Outcomes (KDIGO)" is a global public health approach to face this problem. A formal definition for chronic kidney disease and a staging of kidney diseases from kidney damage with preserved function to kidney failure, were proposed. We reviewed the main mechanisms involved in renal disease progression, with emphasis in the proteinuria and the intrarenal activation of renin angiotensin system. Moreover, the evidence in the literature of therapeutical interventions with proved efficacy in slowing the rate of reduction of renal function is discussed, particularly the optimal control of hypertension, reduction of proteinuria and renin angiotensin system blocking. Finally, we recommend a strategy for the clinical management of patients in the different stages of chronic kidney disease (Rev Méd Chile 2005; 133: 338-48)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.3 20052005-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000300011es10.4067/S0034-98872005000300011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetic nephropathy Glomerular filtration rate Kidney diseases Kidney failure Proteinuria
spellingShingle	Diabetic nephropathy Glomerular filtration rate Kidney diseases Kidney failure Proteinuria Mezzano A,Sergio Aros E,Claudio Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección
description	Chronic kidney disease is a worldwide health problem. The incidence and prevalence of kidney failure is in constant increase, involving poor outcomes and high costs. The leading causes of kidney failure are type 2 diabetes and hypertension. The new initiative "Kidney Disease Improving Global Outcomes (KDIGO)" is a global public health approach to face this problem. A formal definition for chronic kidney disease and a staging of kidney diseases from kidney damage with preserved function to kidney failure, were proposed. We reviewed the main mechanisms involved in renal disease progression, with emphasis in the proteinuria and the intrarenal activation of renin angiotensin system. Moreover, the evidence in the literature of therapeutical interventions with proved efficacy in slowing the rate of reduction of renal function is discussed, particularly the optimal control of hypertension, reduction of proteinuria and renin angiotensin system blocking. Finally, we recommend a strategy for the clinical management of patients in the different stages of chronic kidney disease (Rev Méd Chile 2005; 133: 338-48)
author	Mezzano A,Sergio Aros E,Claudio
author_facet	Mezzano A,Sergio Aros E,Claudio
author_sort	Mezzano A,Sergio
title	Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección
title_short	Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección
title_full	Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección
title_fullStr	Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección
title_full_unstemmed	Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección
title_sort	enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000300011
work_keys_str_mv	AT mezzanoasergio enfermedadrenalcronicaclasificacionmecanismosdeprogresionyestrategiasderenoproteccion AT aroseclaudio enfermedadrenalcronicaclasificacionmecanismosdeprogresionyestrategiasderenoproteccion
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Enfermedad renal crónica: clasificación, mecanismos de progresión y estrategias de renoprotección

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