Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos

Background: Studies performed in Anglo-Saxon countries show that 5% of patients are resistant to the antiplatelet effects of aspirin. Aim: To assess the prevalence of aspirin resistance in a sample of Chilean cardiovascular patients and its association with clinical and laboratory characteristics. P...

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Autores principales:	Dussaillant N,Gastón, Zapata M,Mario, Fardella B,Patricia, Conte L,Guillermo, Cuneo V,Marianela
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Aspirin Cardiovascular diseases Platelet aggregation inhibitors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400003
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spelling	oai:scielo:S0034-988720050004000032005-06-13Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenosDussaillant N,GastónZapata M,MarioFardella B,PatriciaConte L,GuillermoCuneo V,Marianela Aspirin Cardiovascular diseases Platelet aggregation inhibitors Background: Studies performed in Anglo-Saxon countries show that 5% of patients are resistant to the antiplatelet effects of aspirin. Aim: To assess the prevalence of aspirin resistance in a sample of Chilean cardiovascular patients and its association with clinical and laboratory characteristics. Patients and Methods: Ninety nine patients (30 women, 63±10 years) treated for stable cardiovascular diseases with aspirin 100-325 mg/day were studied. Clinical and basic coagulation variables were assessed. Platelet aggregation was studied with platelet rich plasma using three different agonists in an optical aggregometer. Aspirin resistance was defined as an aggregation 20% with arachidonic acid and an aggregation 70% with ADP or collagen. Results: Eleven patients (11.11%, 95% CI= 4.95-17.27%) complied with both criteria and were classified as aspirin resistant. Current smoking was more common in aspirin resistant patients (63.6 vs 29.6%, p=0.039). Conclusions: Aspirin resistance was found in a significant proportion of cardiovascular patients and was more common among current smokersinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.4 20052005-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400003es10.4067/S0034-98872005000400003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Aspirin Cardiovascular diseases Platelet aggregation inhibitors
spellingShingle	Aspirin Cardiovascular diseases Platelet aggregation inhibitors Dussaillant N,Gastón Zapata M,Mario Fardella B,Patricia Conte L,Guillermo Cuneo V,Marianela Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos
description	Background: Studies performed in Anglo-Saxon countries show that 5% of patients are resistant to the antiplatelet effects of aspirin. Aim: To assess the prevalence of aspirin resistance in a sample of Chilean cardiovascular patients and its association with clinical and laboratory characteristics. Patients and Methods: Ninety nine patients (30 women, 63±10 years) treated for stable cardiovascular diseases with aspirin 100-325 mg/day were studied. Clinical and basic coagulation variables were assessed. Platelet aggregation was studied with platelet rich plasma using three different agonists in an optical aggregometer. Aspirin resistance was defined as an aggregation 20% with arachidonic acid and an aggregation 70% with ADP or collagen. Results: Eleven patients (11.11%, 95% CI= 4.95-17.27%) complied with both criteria and were classified as aspirin resistant. Current smoking was more common in aspirin resistant patients (63.6 vs 29.6%, p=0.039). Conclusions: Aspirin resistance was found in a significant proportion of cardiovascular patients and was more common among current smokers
author	Dussaillant N,Gastón Zapata M,Mario Fardella B,Patricia Conte L,Guillermo Cuneo V,Marianela
author_facet	Dussaillant N,Gastón Zapata M,Mario Fardella B,Patricia Conte L,Guillermo Cuneo V,Marianela
author_sort	Dussaillant N,Gastón
title	Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos
title_short	Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos
title_full	Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos
title_fullStr	Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos
title_full_unstemmed	Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos
title_sort	frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400003
work_keys_str_mv	AT dussaillantngaston frecuenciaycaracteristicasdelaresistenciaaaspirinaenpacientescardiovasculareschilenos AT zapatammario frecuenciaycaracteristicasdelaresistenciaaaspirinaenpacientescardiovasculareschilenos AT fardellabpatricia frecuenciaycaracteristicasdelaresistenciaaaspirinaenpacientescardiovasculareschilenos AT contelguillermo frecuenciaycaracteristicasdelaresistenciaaaspirinaenpacientescardiovasculareschilenos AT cuneovmarianela frecuenciaycaracteristicasdelaresistenciaaaspirinaenpacientescardiovasculareschilenos
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Frecuencia y características de la resistencia a aspirina en pacientes cardiovasculares chilenos

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