Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de Chile

The great variability in the clinical presentation of Chagas disease may depend in part in the genetic variability of Trypanosoma cruzi populations. Aim: To compare prepatent period, parasitemia, mortality and histological lesions in mice infected with two populations of Trypanosoma cruzi isolated i...

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Autores principales:	Pizzi P,Tulio, Wallace R,Anne, Villagra O,Rebeca, Muñoz V,Sergio, Ortiz Z,Sylvia, Solari I,Aldo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Chagas disease Protozoan infections
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400006
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spelling	oai:scielo:S0034-988720050004000062005-06-13Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de ChilePizzi P,TulioWallace R,AnneVillagra O,RebecaMuñoz V,SergioOrtiz Z,SylviaSolari I,Aldo Chagas disease Protozoan infections The great variability in the clinical presentation of Chagas disease may depend in part in the genetic variability of Trypanosoma cruzi populations. Aim: To compare prepatent period, parasitemia, mortality and histological lesions in mice infected with two populations of Trypanosoma cruzi isolated in Chile. Material and methods: Two Trypanosoma cruzi populations, isolated from Chilean Triatomides and genetically characterized by kinetoplast restriction fragment DNA profiles, were compared. Two groups of 40 Balb/c mice were studied. Each mouse was inoculated with 10(4) trypomastigotes, of the V-121 and sp COMB 2 Trypanosoma cruzi populations. The prepatent period, parasitemia, mortality and histopathological lesions, at different evolutionary stages of infection were registered during 32 days. Results: Prepatency and mortality were similar in both groups of mice. However, parasitemia was significantly greater in mice inoculated with V-121 than those inoculated with sp COMB 2. Amastigote pseudocysts and inflammation were present only in skeletal muscle and myocardium in both groups of mice. The intensity of tissue involvement was associated to the level of parasitemia, therefore it was greater in mice inoculated with V-121 population. Conclusions: V-121 population of Trypanosoma cruzi caused a greater parasitemia than COMB 2, in inoculated miceinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.4 20052005-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400006es10.4067/S0034-98872005000400006
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Chagas disease Protozoan infections
spellingShingle	Chagas disease Protozoan infections Pizzi P,Tulio Wallace R,Anne Villagra O,Rebeca Muñoz V,Sergio Ortiz Z,Sylvia Solari I,Aldo Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de Chile
description	The great variability in the clinical presentation of Chagas disease may depend in part in the genetic variability of Trypanosoma cruzi populations. Aim: To compare prepatent period, parasitemia, mortality and histological lesions in mice infected with two populations of Trypanosoma cruzi isolated in Chile. Material and methods: Two Trypanosoma cruzi populations, isolated from Chilean Triatomides and genetically characterized by kinetoplast restriction fragment DNA profiles, were compared. Two groups of 40 Balb/c mice were studied. Each mouse was inoculated with 10(4) trypomastigotes, of the V-121 and sp COMB 2 Trypanosoma cruzi populations. The prepatent period, parasitemia, mortality and histopathological lesions, at different evolutionary stages of infection were registered during 32 days. Results: Prepatency and mortality were similar in both groups of mice. However, parasitemia was significantly greater in mice inoculated with V-121 than those inoculated with sp COMB 2. Amastigote pseudocysts and inflammation were present only in skeletal muscle and myocardium in both groups of mice. The intensity of tissue involvement was associated to the level of parasitemia, therefore it was greater in mice inoculated with V-121 population. Conclusions: V-121 population of Trypanosoma cruzi caused a greater parasitemia than COMB 2, in inoculated mice
author	Pizzi P,Tulio Wallace R,Anne Villagra O,Rebeca Muñoz V,Sergio Ortiz Z,Sylvia Solari I,Aldo
author_facet	Pizzi P,Tulio Wallace R,Anne Villagra O,Rebeca Muñoz V,Sergio Ortiz Z,Sylvia Solari I,Aldo
author_sort	Pizzi P,Tulio
title	Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de Chile
title_short	Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de Chile
title_full	Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de Chile
title_fullStr	Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de Chile
title_full_unstemmed	Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de Chile
title_sort	concordancia de lesiones histológicas en ratones infectados por dos poblaciones de trypanosoma cruzi de chile
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400006
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Concordancia de lesiones histológicas en ratones infectados por dos poblaciones de Trypanosoma cruzi de Chile

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