Variabilidad y variantesde la enfermedad de Alzheimer

The heterogeneity and variants of Alzheimer disease (AD) are reviewed. There are cases with a slow or fast evolution and with early or late onset. Most cases are sporadic but there are also hereditary forms. About 50% of patients show neuropsychiatric disorders (depression and psychoses). Some cases...

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Autores principales:	Donoso S,Archibaldo, Behrens P,María Isabel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Early onset Alzheimer disease Focal onset Alzheimer disease Late onset Alzheimer disease Psychosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400013
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spelling	oai:scielo:S0034-988720050004000132005-06-13Variabilidad y variantesde la enfermedad de AlzheimerDonoso S,ArchibaldoBehrens P,María Isabel Early onset Alzheimer disease Focal onset Alzheimer disease Late onset Alzheimer disease Psychosis The heterogeneity and variants of Alzheimer disease (AD) are reviewed. There are cases with a slow or fast evolution and with early or late onset. Most cases are sporadic but there are also hereditary forms. About 50% of patients show neuropsychiatric disorders (depression and psychoses). Some cases have a greater deficit of right or left hemispheric functions. Among the variants, there are forms that start as pure aphasias, predominantly prefrontal cases and posterior cortical forms. Occasionally AD may simulate other disorders such as supranuclear palsy, corticobasal ganglionar degeneration and Jacob-Creutzfeldt disease. Finally, there are mixed forms, in which AD is associated with cerebrovascular disease (very commonly) and with other diseases such as dementia with Lewy bodies. We conclude that AD is a heterogeneous disorder and, therefore, clinical diagnosis may be insufficient. Biological markers and specific imaging studies are needed for a correct clinical diagnosisinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.4 20052005-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400013es10.4067/S0034-98872005000400013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Early onset Alzheimer disease Focal onset Alzheimer disease Late onset Alzheimer disease Psychosis
spellingShingle	Early onset Alzheimer disease Focal onset Alzheimer disease Late onset Alzheimer disease Psychosis Donoso S,Archibaldo Behrens P,María Isabel Variabilidad y variantesde la enfermedad de Alzheimer
description	The heterogeneity and variants of Alzheimer disease (AD) are reviewed. There are cases with a slow or fast evolution and with early or late onset. Most cases are sporadic but there are also hereditary forms. About 50% of patients show neuropsychiatric disorders (depression and psychoses). Some cases have a greater deficit of right or left hemispheric functions. Among the variants, there are forms that start as pure aphasias, predominantly prefrontal cases and posterior cortical forms. Occasionally AD may simulate other disorders such as supranuclear palsy, corticobasal ganglionar degeneration and Jacob-Creutzfeldt disease. Finally, there are mixed forms, in which AD is associated with cerebrovascular disease (very commonly) and with other diseases such as dementia with Lewy bodies. We conclude that AD is a heterogeneous disorder and, therefore, clinical diagnosis may be insufficient. Biological markers and specific imaging studies are needed for a correct clinical diagnosis
author	Donoso S,Archibaldo Behrens P,María Isabel
author_facet	Donoso S,Archibaldo Behrens P,María Isabel
author_sort	Donoso S,Archibaldo
title	Variabilidad y variantesde la enfermedad de Alzheimer
title_short	Variabilidad y variantesde la enfermedad de Alzheimer
title_full	Variabilidad y variantesde la enfermedad de Alzheimer
title_fullStr	Variabilidad y variantesde la enfermedad de Alzheimer
title_full_unstemmed	Variabilidad y variantesde la enfermedad de Alzheimer
title_sort	variabilidad y variantesde la enfermedad de alzheimer
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400013
work_keys_str_mv	AT donososarchibaldo variabilidadyvariantesdelaenfermedaddealzheimer AT behrenspmariaisabel variabilidadyvariantesdelaenfermedaddealzheimer
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Variabilidad y variantesde la enfermedad de Alzheimer

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