Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr

Background: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. Aim: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein...

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Autores principales:	Corvalán R,Alejandro, Akiba,Suminori, Valenzuela B,María Teresa, Cumsille G,Miguel Angel, Koriyama,Chihaya, Argandoña C,Jorge, Backhouse E,Claudia, Bal C,Matilde, Mena U,Fernando, Palma V,Mariana, Eizuru,Yoshito
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Epstein-Barr virus infections Herpes virus 4 human Stomach neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000700001
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spelling	oai:scielo:S0034-988720050007000012014-08-12Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein BarrCorvalán R,AlejandroAkiba,SuminoriValenzuela B,María TeresaCumsille G,Miguel AngelKoriyama,ChihayaArgandoña C,JorgeBackhouse E,ClaudiaBal C,MatildeMena U,FernandoPalma V,MarianaEizuru,Yoshito Epstein-Barr virus infections Herpes virus 4 human Stomach neoplasms Background: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. Aim: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. Material and methods: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus. Results: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57). Conclusions: Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barrinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.7 20052005-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000700001es10.4067/S0034-98872005000700001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Epstein-Barr virus infections Herpes virus 4 human Stomach neoplasms
spellingShingle	Epstein-Barr virus infections Herpes virus 4 human Stomach neoplasms Corvalán R,Alejandro Akiba,Suminori Valenzuela B,María Teresa Cumsille G,Miguel Angel Koriyama,Chihaya Argandoña C,Jorge Backhouse E,Claudia Bal C,Matilde Mena U,Fernando Palma V,Mariana Eizuru,Yoshito Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr
description	Background: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. Aim: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. Material and methods: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus. Results: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus, respectively (p=0.57). Conclusions: Our results, although not significant, show a tendency towards unique characteristics of cardial gastric tumors associated to Epstein Barr
author	Corvalán R,Alejandro Akiba,Suminori Valenzuela B,María Teresa Cumsille G,Miguel Angel Koriyama,Chihaya Argandoña C,Jorge Backhouse E,Claudia Bal C,Matilde Mena U,Fernando Palma V,Mariana Eizuru,Yoshito
author_facet	Corvalán R,Alejandro Akiba,Suminori Valenzuela B,María Teresa Cumsille G,Miguel Angel Koriyama,Chihaya Argandoña C,Jorge Backhouse E,Claudia Bal C,Matilde Mena U,Fernando Palma V,Mariana Eizuru,Yoshito
author_sort	Corvalán R,Alejandro
title	Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr
title_short	Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr
title_full	Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr
title_fullStr	Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr
title_full_unstemmed	Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr
title_sort	características clínico-moleculares del cáncer gástrico cardial asociado al virus epstein barr
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000700001
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Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr

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