Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica

Background:Infantile obesity is associated with metabolic disturbances (hiperinsulinism, impaired glucose, dislypidemia) that determine a higher risk of type 2 diabetes, high blood pressure and atherosclerotic vascular disease in adulthood. Insulin resistance is a central mechanism of complications...

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Autores principales:	Burrows A,Raquel, Burgueño A,Medardo, Leiva B,Laura, Ceballos S,Ximena, Guillier O,Ivette, Gattas Z,Vivien, Lera M,Lidia, Albala B,Cecilia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Body mass index Homeostasis Insulin resistance Obesity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000700007
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spelling	oai:scielo:S0034-988720050007000072014-08-12Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínicaBurrows A,RaquelBurgueño A,MedardoLeiva B,LauraCeballos S,XimenaGuillier O,IvetteGattas Z,VivienLera M,LidiaAlbala B,Cecilia Body mass index Homeostasis Insulin resistance Obesity Background:Infantile obesity is associated with metabolic disturbances (hiperinsulinism, impaired glucose, dislypidemia) that determine a higher risk of type 2 diabetes, high blood pressure and atherosclerotic vascular disease in adulthood. Insulin resistance is a central mechanism of complications of obesity and is associated to body fat mass. Aim: To investigate insulin sensitivity and its association with anthropometric and metabolic variables in obese children. Patients and methods: We studied 314 children aged 6 to 15 years. Of these, 235 had a body mass index (BMI) over the 95 percentile for age and sex (classified as obese) and 79 had a normal body mass index; 161 were pre-pubescent and 153 were pubescent. Weight, height, percentage of total body fat (% TBF) using the sum of 4 skinfolds, blood pressure (BP), waist circumference (WC), basal glucose (Glu) and insulin (Ins) were measured. Insulin sensitivity (IS) was calculated with the homeostasis model assessment (HOMA) and QUICKI index. Serum lipids, postprandial Glu and Ins were measured only in obese children. Results: BMI, WC and % TBF had an inverse and significant correlation with basal IS (p <0.001). Obese children had higher BP, basal Ins, and HOMA and a lower QUICKI index, compared to normal weight children. A low basal IS was present in 58% of obese children. Obese children with low IS had higher WC, % TBF, triglycerides, total/HDL-cholesterol ratio, basal and 2-h post glucose Gli and Ins and lower HDL-cholesterol than obese children with normal IS. In prepubescent children, the risk of a low IS was 2.43 times higher with a TBF over 33%. In pubescent children, it was 2.92 times higher with a TBF over 37%. Conclusions: Low IS in prepubescent and pubescent obese children is associated with central obesity and a higher cardiovascularinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.7 20052005-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000700007es10.4067/S0034-98872005000700007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Body mass index Homeostasis Insulin resistance Obesity
spellingShingle	Body mass index Homeostasis Insulin resistance Obesity Burrows A,Raquel Burgueño A,Medardo Leiva B,Laura Ceballos S,Ximena Guillier O,Ivette Gattas Z,Vivien Lera M,Lidia Albala B,Cecilia Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica
description	Background:Infantile obesity is associated with metabolic disturbances (hiperinsulinism, impaired glucose, dislypidemia) that determine a higher risk of type 2 diabetes, high blood pressure and atherosclerotic vascular disease in adulthood. Insulin resistance is a central mechanism of complications of obesity and is associated to body fat mass. Aim: To investigate insulin sensitivity and its association with anthropometric and metabolic variables in obese children. Patients and methods: We studied 314 children aged 6 to 15 years. Of these, 235 had a body mass index (BMI) over the 95 percentile for age and sex (classified as obese) and 79 had a normal body mass index; 161 were pre-pubescent and 153 were pubescent. Weight, height, percentage of total body fat (% TBF) using the sum of 4 skinfolds, blood pressure (BP), waist circumference (WC), basal glucose (Glu) and insulin (Ins) were measured. Insulin sensitivity (IS) was calculated with the homeostasis model assessment (HOMA) and QUICKI index. Serum lipids, postprandial Glu and Ins were measured only in obese children. Results: BMI, WC and % TBF had an inverse and significant correlation with basal IS (p <0.001). Obese children had higher BP, basal Ins, and HOMA and a lower QUICKI index, compared to normal weight children. A low basal IS was present in 58% of obese children. Obese children with low IS had higher WC, % TBF, triglycerides, total/HDL-cholesterol ratio, basal and 2-h post glucose Gli and Ins and lower HDL-cholesterol than obese children with normal IS. In prepubescent children, the risk of a low IS was 2.43 times higher with a TBF over 33%. In pubescent children, it was 2.92 times higher with a TBF over 37%. Conclusions: Low IS in prepubescent and pubescent obese children is associated with central obesity and a higher cardiovascular
author	Burrows A,Raquel Burgueño A,Medardo Leiva B,Laura Ceballos S,Ximena Guillier O,Ivette Gattas Z,Vivien Lera M,Lidia Albala B,Cecilia
author_facet	Burrows A,Raquel Burgueño A,Medardo Leiva B,Laura Ceballos S,Ximena Guillier O,Ivette Gattas Z,Vivien Lera M,Lidia Albala B,Cecilia
author_sort	Burrows A,Raquel
title	Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica
title_short	Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica
title_full	Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica
title_fullStr	Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica
title_full_unstemmed	Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica
title_sort	perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000700007
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Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica

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