Enfermedad de von Willebrand como manifestación clínica inhabitual del hipotiroidismo primario: Caso clínico

Patients with hypothyroidism may have a minor increase in their bleeding tendency, causing easy bruising and menorrhagia. There is a positive correlation between factor VIII coagulant activity and thyroxin serum levels. Thus, patients with hypothyroidism have an acquired coagulation defect that is r...

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Autores principales:	Concha N,Rodrigo, Borzone V,María Alejandra, Castillo N,Marcelo, Rossle S,Alberto, Quevedo L,Iván
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Hashimoto disease Thyroiditis, autoimmune von Willebrand disease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000700009
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spelling	oai:scielo:S0034-988720050007000092014-08-12Enfermedad de von Willebrand como manifestación clínica inhabitual del hipotiroidismo primario: Caso clínicoConcha N,RodrigoBorzone V,María AlejandraCastillo N,MarceloRossle S,AlbertoQuevedo L,Iván Hashimoto disease Thyroiditis, autoimmune von Willebrand disease Patients with hypothyroidism may have a minor increase in their bleeding tendency, causing easy bruising and menorrhagia. There is a positive correlation between factor VIII coagulant activity and thyroxin serum levels. Thus, patients with hypothyroidism have an acquired coagulation defect that is reversible with thyroxin supplementation. We report two sisters, aged 13 and 11 years, who met the criteria for von Willebrand's disease at the age of eight. Both sisters had a primary hypothyroidism due to Hashimoto's thyroiditis, diagnosed three years later. Thyroid hormone replacement normalized von Willebrand factor, factor VIII, and the bleeding diathesis disappeared. Acquired von Willebrand's disease is an unusual manifestation of hypothyroidism. However the possibility of hypothyroidism should be considered in patients presenting with von Willebrand diseaseinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.7 20052005-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000700009es10.4067/S0034-98872005000700009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hashimoto disease Thyroiditis, autoimmune von Willebrand disease
spellingShingle	Hashimoto disease Thyroiditis, autoimmune von Willebrand disease Concha N,Rodrigo Borzone V,María Alejandra Castillo N,Marcelo Rossle S,Alberto Quevedo L,Iván Enfermedad de von Willebrand como manifestación clínica inhabitual del hipotiroidismo primario: Caso clínico
description	Patients with hypothyroidism may have a minor increase in their bleeding tendency, causing easy bruising and menorrhagia. There is a positive correlation between factor VIII coagulant activity and thyroxin serum levels. Thus, patients with hypothyroidism have an acquired coagulation defect that is reversible with thyroxin supplementation. We report two sisters, aged 13 and 11 years, who met the criteria for von Willebrand's disease at the age of eight. Both sisters had a primary hypothyroidism due to Hashimoto's thyroiditis, diagnosed three years later. Thyroid hormone replacement normalized von Willebrand factor, factor VIII, and the bleeding diathesis disappeared. Acquired von Willebrand's disease is an unusual manifestation of hypothyroidism. However the possibility of hypothyroidism should be considered in patients presenting with von Willebrand disease
author	Concha N,Rodrigo Borzone V,María Alejandra Castillo N,Marcelo Rossle S,Alberto Quevedo L,Iván
author_facet	Concha N,Rodrigo Borzone V,María Alejandra Castillo N,Marcelo Rossle S,Alberto Quevedo L,Iván
author_sort	Concha N,Rodrigo
title	Enfermedad de von Willebrand como manifestación clínica inhabitual del hipotiroidismo primario: Caso clínico
title_short	Enfermedad de von Willebrand como manifestación clínica inhabitual del hipotiroidismo primario: Caso clínico
title_full	Enfermedad de von Willebrand como manifestación clínica inhabitual del hipotiroidismo primario: Caso clínico
title_fullStr	Enfermedad de von Willebrand como manifestación clínica inhabitual del hipotiroidismo primario: Caso clínico
title_full_unstemmed	Enfermedad de von Willebrand como manifestación clínica inhabitual del hipotiroidismo primario: Caso clínico
title_sort	enfermedad de von willebrand como manifestación clínica inhabitual del hipotiroidismo primario: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000700009
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Enfermedad de von Willebrand como manifestación clínica inhabitual del hipotiroidismo primario: Caso clínico

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