Terapias emergentes en artritis reumatoide

The use of biological agents such as etanercept, infliximab, adalimumab and anakinra has been recently approved for the treatment of rheumatoid arthritis. All are effective controlling signs and symptoms and inhibiting disease progression. To overcome the problems generated by their high costs and p...

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Autores principales:	Aguillón G,Juan C, Cruzat C,Andrea, Contreras-Levicoy,Juan, Dotte G,Andrés, Pesce R,Bárbara, Aravena M,Octavio, Salazar A,Lorena, Catalán M,Diego, Abello C,Paula, Aguirre D,Adam, Llanos M,Carolina, Cuchacovich T,Miguel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Arthritis, rheumatoid Biological therapy Gene therapy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000800014
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spelling	oai:scielo:S0034-988720050008000142014-08-12Terapias emergentes en artritis reumatoideAguillón G,Juan CCruzat C,AndreaContreras-Levicoy,JuanDotte G,AndrésPesce R,BárbaraAravena M,OctavioSalazar A,LorenaCatalán M,DiegoAbello C,PaulaAguirre D,AdamLlanos M,CarolinaCuchacovich T,Miguel Arthritis, rheumatoid Biological therapy Gene therapy The use of biological agents such as etanercept, infliximab, adalimumab and anakinra has been recently approved for the treatment of rheumatoid arthritis. All are effective controlling signs and symptoms and inhibiting disease progression. To overcome the problems generated by their high costs and possible participation in reactivating latent infections, other therapeutic tools are being developed. Gene therapy using expression vectors carrying genes coding for specific proteins, may interfere in key points involved in the pathogenesis of the disease. Intra-articular administration of cDNA coding for soluble TNF receptors, IL-1, or IL-1Ra decreases signs of the disease in animal models. Vectors, expressing inhibitors of signal transduction pathways involving to NF-kB and JAK-STAT-3, are effective in modulating joint inflammation in mice. The use of antigen-pulsed antigen presenting cells or dendritic cells (DC) bound to apoptosis-inducing molecules, specifically eliminates autoreactive T cells. Other novel approach attempts the development of T regulatory-inducing tolerogenic DC-based vaccines that inhibit autoreactive T cells, through the secretion of suppressing cytokines or by other mechanisms to be elucidated. Oral tolerance induction to auto-antigens is also a successful experimental strategy under study. Current research aims to control peripheral tolerance in rheumatoid arthritis patientsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.8 20052005-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000800014es10.4067/S0034-98872005000800014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Arthritis, rheumatoid Biological therapy Gene therapy
spellingShingle	Arthritis, rheumatoid Biological therapy Gene therapy Aguillón G,Juan C Cruzat C,Andrea Contreras-Levicoy,Juan Dotte G,Andrés Pesce R,Bárbara Aravena M,Octavio Salazar A,Lorena Catalán M,Diego Abello C,Paula Aguirre D,Adam Llanos M,Carolina Cuchacovich T,Miguel Terapias emergentes en artritis reumatoide
description	The use of biological agents such as etanercept, infliximab, adalimumab and anakinra has been recently approved for the treatment of rheumatoid arthritis. All are effective controlling signs and symptoms and inhibiting disease progression. To overcome the problems generated by their high costs and possible participation in reactivating latent infections, other therapeutic tools are being developed. Gene therapy using expression vectors carrying genes coding for specific proteins, may interfere in key points involved in the pathogenesis of the disease. Intra-articular administration of cDNA coding for soluble TNF receptors, IL-1, or IL-1Ra decreases signs of the disease in animal models. Vectors, expressing inhibitors of signal transduction pathways involving to NF-kB and JAK-STAT-3, are effective in modulating joint inflammation in mice. The use of antigen-pulsed antigen presenting cells or dendritic cells (DC) bound to apoptosis-inducing molecules, specifically eliminates autoreactive T cells. Other novel approach attempts the development of T regulatory-inducing tolerogenic DC-based vaccines that inhibit autoreactive T cells, through the secretion of suppressing cytokines or by other mechanisms to be elucidated. Oral tolerance induction to auto-antigens is also a successful experimental strategy under study. Current research aims to control peripheral tolerance in rheumatoid arthritis patients
author	Aguillón G,Juan C Cruzat C,Andrea Contreras-Levicoy,Juan Dotte G,Andrés Pesce R,Bárbara Aravena M,Octavio Salazar A,Lorena Catalán M,Diego Abello C,Paula Aguirre D,Adam Llanos M,Carolina Cuchacovich T,Miguel
author_facet	Aguillón G,Juan C Cruzat C,Andrea Contreras-Levicoy,Juan Dotte G,Andrés Pesce R,Bárbara Aravena M,Octavio Salazar A,Lorena Catalán M,Diego Abello C,Paula Aguirre D,Adam Llanos M,Carolina Cuchacovich T,Miguel
author_sort	Aguillón G,Juan C
title	Terapias emergentes en artritis reumatoide
title_short	Terapias emergentes en artritis reumatoide
title_full	Terapias emergentes en artritis reumatoide
title_fullStr	Terapias emergentes en artritis reumatoide
title_full_unstemmed	Terapias emergentes en artritis reumatoide
title_sort	terapias emergentes en artritis reumatoide
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000800014
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Terapias emergentes en artritis reumatoide

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