Poliposis familiar: Alternativas terapéuticas y estudio de los familiares

Background: To reduce the mortality associated to Familial Adenomatous Polyposis (FAP), screening of close relatives of patients with the disease is crucial. Aim: To analyze the results of the surgical treatment of patients with FAP, and to evaluate the family screening. Patients and Methods: Clinic...

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Autores principales:	Soto D,Gonzalo, López-Köstner,Francisco, Zárate C,Alejandro, Vuletin S,Fernando, Rahmer O,Alejandro, León G,Francisca, Zúñiga D,Álvaro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Adenomatous polyposis coli Colorectal neoplasms Familial adenomatous polyposis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000900007
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spelling	oai:scielo:S0034-988720050009000072005-11-09Poliposis familiar: Alternativas terapéuticas y estudio de los familiaresSoto D,GonzaloLópez-Köstner,FranciscoZárate C,AlejandroVuletin S,FernandoRahmer O,AlejandroLeón G,FranciscaZúñiga D,Álvaro Adenomatous polyposis coli Colorectal neoplasms Familial adenomatous polyposis Background: To reduce the mortality associated to Familial Adenomatous Polyposis (FAP), screening of close relatives of patients with the disease is crucial. Aim: To analyze the results of the surgical treatment of patients with FAP, and to evaluate the family screening. Patients and Methods: Clinical records of patients operated in our institution since 1977, were reviewed analyzing surgical and pathological results, and follow up. In their family members, we evaluated and analyzed the performance of screening tests, former surgeries, history of disease-related cancer and mortality, all due to FAP. Results: Between January 1977 and August 2002, 15 patients were operated on. Of these, only 33% consulted on the setting of a familial screening. A proctocolectomy and terminal ileostomy was performed in 27% of patients; 20% had a proctocolectomy and ileal pouch, and 53% underwent a total colectomy with ileo-rectal anastomosis. Morbidity and mortality were 7% and 0%, respectively. Twenty percent had a colorectal cancer. During a median of 68 months follow-up, the disease-related survival was 92%; no cancer of the rectal stump was detected. Of the 122 family members identified, only 33% with clear indication of screening underwent a colonoscopy. Twenty-nine percent had a confirmed FAP and were operated: in 61% of them a colorectal cancer was found, and 91% of these died. Conclusions: The results of the surgical treatment of FAP are satisfactory. Nevertheless, family screening should be improved to reduce the high rates of mortality revealed in the study of other family members (Rev Méd Chile 2005; 133: 1043-50).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.9 20052005-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000900007es10.4067/S0034-98872005000900007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Adenomatous polyposis coli Colorectal neoplasms Familial adenomatous polyposis
spellingShingle	Adenomatous polyposis coli Colorectal neoplasms Familial adenomatous polyposis Soto D,Gonzalo López-Köstner,Francisco Zárate C,Alejandro Vuletin S,Fernando Rahmer O,Alejandro León G,Francisca Zúñiga D,Álvaro Poliposis familiar: Alternativas terapéuticas y estudio de los familiares
description	Background: To reduce the mortality associated to Familial Adenomatous Polyposis (FAP), screening of close relatives of patients with the disease is crucial. Aim: To analyze the results of the surgical treatment of patients with FAP, and to evaluate the family screening. Patients and Methods: Clinical records of patients operated in our institution since 1977, were reviewed analyzing surgical and pathological results, and follow up. In their family members, we evaluated and analyzed the performance of screening tests, former surgeries, history of disease-related cancer and mortality, all due to FAP. Results: Between January 1977 and August 2002, 15 patients were operated on. Of these, only 33% consulted on the setting of a familial screening. A proctocolectomy and terminal ileostomy was performed in 27% of patients; 20% had a proctocolectomy and ileal pouch, and 53% underwent a total colectomy with ileo-rectal anastomosis. Morbidity and mortality were 7% and 0%, respectively. Twenty percent had a colorectal cancer. During a median of 68 months follow-up, the disease-related survival was 92%; no cancer of the rectal stump was detected. Of the 122 family members identified, only 33% with clear indication of screening underwent a colonoscopy. Twenty-nine percent had a confirmed FAP and were operated: in 61% of them a colorectal cancer was found, and 91% of these died. Conclusions: The results of the surgical treatment of FAP are satisfactory. Nevertheless, family screening should be improved to reduce the high rates of mortality revealed in the study of other family members (Rev Méd Chile 2005; 133: 1043-50).
author	Soto D,Gonzalo López-Köstner,Francisco Zárate C,Alejandro Vuletin S,Fernando Rahmer O,Alejandro León G,Francisca Zúñiga D,Álvaro
author_facet	Soto D,Gonzalo López-Köstner,Francisco Zárate C,Alejandro Vuletin S,Fernando Rahmer O,Alejandro León G,Francisca Zúñiga D,Álvaro
author_sort	Soto D,Gonzalo
title	Poliposis familiar: Alternativas terapéuticas y estudio de los familiares
title_short	Poliposis familiar: Alternativas terapéuticas y estudio de los familiares
title_full	Poliposis familiar: Alternativas terapéuticas y estudio de los familiares
title_fullStr	Poliposis familiar: Alternativas terapéuticas y estudio de los familiares
title_full_unstemmed	Poliposis familiar: Alternativas terapéuticas y estudio de los familiares
title_sort	poliposis familiar: alternativas terapéuticas y estudio de los familiares
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000900007
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Poliposis familiar: Alternativas terapéuticas y estudio de los familiares

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