Hepatitis crónica por virus C: factores asociados a la severidad del daño histológico

Twenty percent of patients with chronic hepatitis C evolve to cirrhosis in 10 to 20 years. The degree of steatosis and hepatic iron stores in liver biopsy increase the risk. Age, high body mass index, diabetes mellitus and alcohol consumption are factors associated to the severity of liver damage. A...

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Autores principales:	Orellana N,Ivonne, Poniachik T,Jaime, Smok S,Gladys, Madrid S,Ana María, Menéndez A,Alejandra, Tobar A,Eduardo, Brahm B,Javier
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Diabetes mellitus Hemochromatosis Hemosiderosis Hepatitis C chronic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005001100006
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spelling	oai:scielo:S0034-988720050011000062006-01-24Hepatitis crónica por virus C: factores asociados a la severidad del daño histológicoOrellana N,IvonnePoniachik T,JaimeSmok S,GladysMadrid S,Ana MaríaMenéndez A,AlejandraTobar A,EduardoBrahm B,Javier Diabetes mellitus Hemochromatosis Hemosiderosis Hepatitis C chronic Twenty percent of patients with chronic hepatitis C evolve to cirrhosis in 10 to 20 years. The degree of steatosis and hepatic iron stores in liver biopsy increase the risk. Age, high body mass index, diabetes mellitus and alcohol consumption are factors associated to the severity of liver damage. Aim: To study the association of steatosis and increased iron stores in the liver biopsy and age, overweight, alcohol consumption and diabetes with the severity of liver damage in patients with hepatitis C virus infection. Patients and methods: Retrospective study of 84 liver biopsies of patients with chronic infection with hepatitis C virus were studied. The pathological appearance was classified as stage I when chronic hepatitis with mild activity without fibrosis was observed; as stage II when moderate chronic hepatitis with mild fibrosis was observed and as stage III when there was a moderate chronic hepatitis with fibrosis or cirrhosis. The amount of steatosis and iron deposition in the biopsy were also assessed. Results: Forty one percent of patients were in stage I, 32% in stage II and 27% in stage III. Patients in stage I were younger than those in stages II and III (40.7 and 52.2 years respectively, p <0,001). No association between the severity of liver damage and the degree of steatosis, hemosiderosis, body mass index or alcohol intake, was observed. The frecuency of diabetes mellitus increased along with pathological staging (3, 15 and 30% in stages I, II and III, respectively, p <0,05). Conclusions: This study confirms that severity of chronic hepatitis C is associated with age and the presence of diabetes mellitusinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.11 20052005-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005001100006es10.4067/S0034-98872005001100006
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes mellitus Hemochromatosis Hemosiderosis Hepatitis C chronic
spellingShingle	Diabetes mellitus Hemochromatosis Hemosiderosis Hepatitis C chronic Orellana N,Ivonne Poniachik T,Jaime Smok S,Gladys Madrid S,Ana María Menéndez A,Alejandra Tobar A,Eduardo Brahm B,Javier Hepatitis crónica por virus C: factores asociados a la severidad del daño histológico
description	Twenty percent of patients with chronic hepatitis C evolve to cirrhosis in 10 to 20 years. The degree of steatosis and hepatic iron stores in liver biopsy increase the risk. Age, high body mass index, diabetes mellitus and alcohol consumption are factors associated to the severity of liver damage. Aim: To study the association of steatosis and increased iron stores in the liver biopsy and age, overweight, alcohol consumption and diabetes with the severity of liver damage in patients with hepatitis C virus infection. Patients and methods: Retrospective study of 84 liver biopsies of patients with chronic infection with hepatitis C virus were studied. The pathological appearance was classified as stage I when chronic hepatitis with mild activity without fibrosis was observed; as stage II when moderate chronic hepatitis with mild fibrosis was observed and as stage III when there was a moderate chronic hepatitis with fibrosis or cirrhosis. The amount of steatosis and iron deposition in the biopsy were also assessed. Results: Forty one percent of patients were in stage I, 32% in stage II and 27% in stage III. Patients in stage I were younger than those in stages II and III (40.7 and 52.2 years respectively, p <0,001). No association between the severity of liver damage and the degree of steatosis, hemosiderosis, body mass index or alcohol intake, was observed. The frecuency of diabetes mellitus increased along with pathological staging (3, 15 and 30% in stages I, II and III, respectively, p <0,05). Conclusions: This study confirms that severity of chronic hepatitis C is associated with age and the presence of diabetes mellitus
author	Orellana N,Ivonne Poniachik T,Jaime Smok S,Gladys Madrid S,Ana María Menéndez A,Alejandra Tobar A,Eduardo Brahm B,Javier
author_facet	Orellana N,Ivonne Poniachik T,Jaime Smok S,Gladys Madrid S,Ana María Menéndez A,Alejandra Tobar A,Eduardo Brahm B,Javier
author_sort	Orellana N,Ivonne
title	Hepatitis crónica por virus C: factores asociados a la severidad del daño histológico
title_short	Hepatitis crónica por virus C: factores asociados a la severidad del daño histológico
title_full	Hepatitis crónica por virus C: factores asociados a la severidad del daño histológico
title_fullStr	Hepatitis crónica por virus C: factores asociados a la severidad del daño histológico
title_full_unstemmed	Hepatitis crónica por virus C: factores asociados a la severidad del daño histológico
title_sort	hepatitis crónica por virus c: factores asociados a la severidad del daño histológico
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005001100006
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Hepatitis crónica por virus C: factores asociados a la severidad del daño histológico

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