Enfermedad Celíaca del adulto: Experiencia clínica

The prevalence of celiac disease (CD) is unknown in Chile. We have recently noted a rise in the number of cases diagnosed among adults. Aim: To describe the clinical characteristics of a group of adult celiac patients. Patients and methods: Clinical data of patients older than 15 years with positive...

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Autores principales:	Mancilla A,Carla, Madrid S,Ana María, Valenzuela E,Jorge, Morales B,Antonio, Hurtado H,Carmen, Smok S,Gladys, Ledezma R,Rodrigo, Castillo M,Iván, Rivas Q,Mauricio, Brahm B,Javier
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2005
Materias:	Celiac disease Gluten Transglutaminase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005001100007
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spelling	oai:scielo:S0034-988720050011000072006-01-24Enfermedad Celíaca del adulto: Experiencia clínicaMancilla A,CarlaMadrid S,Ana MaríaValenzuela E,JorgeMorales B,AntonioHurtado H,CarmenSmok S,GladysLedezma R,RodrigoCastillo M,IvánRivas Q,MauricioBrahm B,Javier Celiac disease Gluten Transglutaminase The prevalence of celiac disease (CD) is unknown in Chile. We have recently noted a rise in the number of cases diagnosed among adults. Aim: To describe the clinical characteristics of a group of adult celiac patients. Patients and methods: Clinical data of patients older than 15 years with positive antitransglutaminase or antiendomysial autoantibodies and a duodenal biopsy characteristic of CD were retrospectively reviewed. Age at diagnosis, symptoms and signs and laboratory, endoscopic and histological findings, were analyzed. Results: Thirty seven patients (28 women), were studied. Median age at diagnosis was 41 years (range 15-69). Main symptoms and signs were diarrhea (78%), weight loss (38%) and abdominal pain (38%). Anemia was found in 49%, elevation of ESR in 57%, elevation of alkaline phosphatases in 54%, elevation of aspartate aminotransferase in 38% and a rise in alanine aminotransferase in 27%. Antiendomysial antibodies were positive in 17/22 (77%) and antitransglutaminase in 19/22 (86%) patients. Endoscopic findings were suggestive of CD in 47% of cases and duodenal biopsy showed intestinal villi atrophy in 34 (92%) patients. The three patients with normal histology had positive serology and a good response to gluten free diet. Conclusions: CD should be considered in the differential diagnosis of patients with unespecific digestive symptons, even when they present late in adult life. Serologic markers are a good diagnostic tool. A normal duodenal pathology does not exclude the diagnosis, if other diagnostic features are presentinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.133 n.11 20052005-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005001100007es10.4067/S0034-98872005001100007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Celiac disease Gluten Transglutaminase
spellingShingle	Celiac disease Gluten Transglutaminase Mancilla A,Carla Madrid S,Ana María Valenzuela E,Jorge Morales B,Antonio Hurtado H,Carmen Smok S,Gladys Ledezma R,Rodrigo Castillo M,Iván Rivas Q,Mauricio Brahm B,Javier Enfermedad Celíaca del adulto: Experiencia clínica
description	The prevalence of celiac disease (CD) is unknown in Chile. We have recently noted a rise in the number of cases diagnosed among adults. Aim: To describe the clinical characteristics of a group of adult celiac patients. Patients and methods: Clinical data of patients older than 15 years with positive antitransglutaminase or antiendomysial autoantibodies and a duodenal biopsy characteristic of CD were retrospectively reviewed. Age at diagnosis, symptoms and signs and laboratory, endoscopic and histological findings, were analyzed. Results: Thirty seven patients (28 women), were studied. Median age at diagnosis was 41 years (range 15-69). Main symptoms and signs were diarrhea (78%), weight loss (38%) and abdominal pain (38%). Anemia was found in 49%, elevation of ESR in 57%, elevation of alkaline phosphatases in 54%, elevation of aspartate aminotransferase in 38% and a rise in alanine aminotransferase in 27%. Antiendomysial antibodies were positive in 17/22 (77%) and antitransglutaminase in 19/22 (86%) patients. Endoscopic findings were suggestive of CD in 47% of cases and duodenal biopsy showed intestinal villi atrophy in 34 (92%) patients. The three patients with normal histology had positive serology and a good response to gluten free diet. Conclusions: CD should be considered in the differential diagnosis of patients with unespecific digestive symptons, even when they present late in adult life. Serologic markers are a good diagnostic tool. A normal duodenal pathology does not exclude the diagnosis, if other diagnostic features are present
author	Mancilla A,Carla Madrid S,Ana María Valenzuela E,Jorge Morales B,Antonio Hurtado H,Carmen Smok S,Gladys Ledezma R,Rodrigo Castillo M,Iván Rivas Q,Mauricio Brahm B,Javier
author_facet	Mancilla A,Carla Madrid S,Ana María Valenzuela E,Jorge Morales B,Antonio Hurtado H,Carmen Smok S,Gladys Ledezma R,Rodrigo Castillo M,Iván Rivas Q,Mauricio Brahm B,Javier
author_sort	Mancilla A,Carla
title	Enfermedad Celíaca del adulto: Experiencia clínica
title_short	Enfermedad Celíaca del adulto: Experiencia clínica
title_full	Enfermedad Celíaca del adulto: Experiencia clínica
title_fullStr	Enfermedad Celíaca del adulto: Experiencia clínica
title_full_unstemmed	Enfermedad Celíaca del adulto: Experiencia clínica
title_sort	enfermedad celíaca del adulto: experiencia clínica
publisher	Sociedad Médica de Santiago
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872005001100007
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Enfermedad Celíaca del adulto: Experiencia clínica

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