Sensibilidad a IGF-I en niños pequeños para la edad gestacional

Background: The lack of catch up growth (CUG) in small for gestational age (SGA) children may be related to a reduced sensitivity to insulin growth factor 1 (IGF-I). Aim: To assess the sensitivity to IGF-I in small for gestational age children, measuring basal and post IGF-I nocturnal profile of gro...

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Autores principales:	Román R,Rossana, Iñíguez V,Germán, Salazar C,Teresa, Avila A,Alejandra, Barrera P,Alvaro, Fuentes G,Ariel, Mericq G,Verónica, Gunn,Ronald D, Cassorla G,Fernando
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Infant small for gestational age Insulin-like growth factor I Human growth hormone
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000100003
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spelling	oai:scielo:S0034-988720060001000032006-03-08Sensibilidad a IGF-I en niños pequeños para la edad gestacionalRomán R,RossanaIñíguez V,GermánSalazar C,TeresaAvila A,AlejandraBarrera P,AlvaroFuentes G,ArielMericq G,VerónicaGunn,Ronald DCassorla G,Fernando Infant small for gestational age Insulin-like growth factor I Human growth hormone Background: The lack of catch up growth (CUG) in small for gestational age (SGA) children may be related to a reduced sensitivity to insulin growth factor 1 (IGF-I). Aim: To assess the sensitivity to IGF-I in small for gestational age children, measuring basal and post IGF-I nocturnal profile of growth hormone (GH). Patients and methods: We studied 34 prepubertal SGA children aged 4 to 11 years. Twenty three had CUG and 11 did not have CUG. As an IGF-I sensitivity test, nocturnal GH levels were measured every 20 minutes from 23:00 h to 07:00 h, both under baseline conditions and after the administration of a subcutaneous bolus of 1 mg/kg/body weight of the IGF-I + IGFBP-3 complex (Somatokine®). Results: At the time of the study, the Z scores for height among children with and without CUG were -1.55 ± 0.22 and -3.24 ± 0.28, respectively (p <0.0001). There were no statistical differences between CUG + vs CUG- patients in mean basal GH (6.6 ± 0.5 and 5.6 ± 0.6 ng/ml, respectively). After Somatokine® administration, mean GH, and the mean GH area under the curve (AUC) decreased significantly in both groups. However, mean overnight GH AUC decreased in all SGA children with CUG, after Somatokine® administration, whereas 3 out of 11 SGA children without CUG had an increase in their mean GH AUC in response to Somatokine®. Conclusions: These findings suggest that pituitary sensitivity to IGF-I may be decreased in some SGA children without CUGinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.1 20062006-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000100003es10.4067/S0034-98872006000100003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Infant small for gestational age Insulin-like growth factor I Human growth hormone
spellingShingle	Infant small for gestational age Insulin-like growth factor I Human growth hormone Román R,Rossana Iñíguez V,Germán Salazar C,Teresa Avila A,Alejandra Barrera P,Alvaro Fuentes G,Ariel Mericq G,Verónica Gunn,Ronald D Cassorla G,Fernando Sensibilidad a IGF-I en niños pequeños para la edad gestacional
description	Background: The lack of catch up growth (CUG) in small for gestational age (SGA) children may be related to a reduced sensitivity to insulin growth factor 1 (IGF-I). Aim: To assess the sensitivity to IGF-I in small for gestational age children, measuring basal and post IGF-I nocturnal profile of growth hormone (GH). Patients and methods: We studied 34 prepubertal SGA children aged 4 to 11 years. Twenty three had CUG and 11 did not have CUG. As an IGF-I sensitivity test, nocturnal GH levels were measured every 20 minutes from 23:00 h to 07:00 h, both under baseline conditions and after the administration of a subcutaneous bolus of 1 mg/kg/body weight of the IGF-I + IGFBP-3 complex (Somatokine®). Results: At the time of the study, the Z scores for height among children with and without CUG were -1.55 ± 0.22 and -3.24 ± 0.28, respectively (p <0.0001). There were no statistical differences between CUG + vs CUG- patients in mean basal GH (6.6 ± 0.5 and 5.6 ± 0.6 ng/ml, respectively). After Somatokine® administration, mean GH, and the mean GH area under the curve (AUC) decreased significantly in both groups. However, mean overnight GH AUC decreased in all SGA children with CUG, after Somatokine® administration, whereas 3 out of 11 SGA children without CUG had an increase in their mean GH AUC in response to Somatokine®. Conclusions: These findings suggest that pituitary sensitivity to IGF-I may be decreased in some SGA children without CUG
author	Román R,Rossana Iñíguez V,Germán Salazar C,Teresa Avila A,Alejandra Barrera P,Alvaro Fuentes G,Ariel Mericq G,Verónica Gunn,Ronald D Cassorla G,Fernando
author_facet	Román R,Rossana Iñíguez V,Germán Salazar C,Teresa Avila A,Alejandra Barrera P,Alvaro Fuentes G,Ariel Mericq G,Verónica Gunn,Ronald D Cassorla G,Fernando
author_sort	Román R,Rossana
title	Sensibilidad a IGF-I en niños pequeños para la edad gestacional
title_short	Sensibilidad a IGF-I en niños pequeños para la edad gestacional
title_full	Sensibilidad a IGF-I en niños pequeños para la edad gestacional
title_fullStr	Sensibilidad a IGF-I en niños pequeños para la edad gestacional
title_full_unstemmed	Sensibilidad a IGF-I en niños pequeños para la edad gestacional
title_sort	sensibilidad a igf-i en niños pequeños para la edad gestacional
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000100003
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Sensibilidad a IGF-I en niños pequeños para la edad gestacional

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