Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico

Background: The family of lectins known as galectins (galectins 1-14) are involved in the regulation of the immune system and in oncogenesis. During a search for antigens recognized by antibodies produced by a patient with systemic lupus erythematosus (SLE) we found reactivity against galectin-8, fo...

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Autores principales:	Pardo,Evelyn, Cárcamo,Claudia, Massardo,Loreto, Mezzano,Verónica, Jacobelli,Sergio, González,Alfonso, Soza G,Andrea
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Autoantibodies Galectin 8 Lupus erythematosus, systemic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200004
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spelling	oai:scielo:S0034-988720060002000042006-03-17Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémicoPardo,EvelynCárcamo,ClaudiaMassardo,LoretoMezzano,VerónicaJacobelli,SergioGonzález,AlfonsoSoza G,Andrea Autoantibodies Galectin 8 Lupus erythematosus, systemic Background: The family of lectins known as galectins (galectins 1-14) are involved in the regulation of the immune system and in oncogenesis. During a search for antigens recognized by antibodies produced by a patient with systemic lupus erythematosus (SLE) we found reactivity against galectin-8, for which autoantibodies have not been previously described. Aim: To determine the frequency of autoantibodies against galectin-8 in lupus patients compared with healthy controls. Patients and Methods: Galectin-8 was purified from a bacterial expression system and used in immunoblot assays as antigen to screen the sera of 55 SLE patients and matched controls. Disease activity was evaluated using the Mexican Modification of the Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). Results: Reactivity against galectin-8 was detected in 30% of SLE patients, compared to 7% of controls (p=0.003). We could not detect any particular SLE manifestation associated to the presence of these autoantibodies. Conclusions: This is the first description of autoantibodies against galectin-8. Its higher frequency in patients with SLE suggests a pathogenic role. Further studies are needed to determine their clinical relevanceinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.2 20062006-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200004es10.4067/S0034-98872006000200004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Autoantibodies Galectin 8 Lupus erythematosus, systemic
spellingShingle	Autoantibodies Galectin 8 Lupus erythematosus, systemic Pardo,Evelyn Cárcamo,Claudia Massardo,Loreto Mezzano,Verónica Jacobelli,Sergio González,Alfonso Soza G,Andrea Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico
description	Background: The family of lectins known as galectins (galectins 1-14) are involved in the regulation of the immune system and in oncogenesis. During a search for antigens recognized by antibodies produced by a patient with systemic lupus erythematosus (SLE) we found reactivity against galectin-8, for which autoantibodies have not been previously described. Aim: To determine the frequency of autoantibodies against galectin-8 in lupus patients compared with healthy controls. Patients and Methods: Galectin-8 was purified from a bacterial expression system and used in immunoblot assays as antigen to screen the sera of 55 SLE patients and matched controls. Disease activity was evaluated using the Mexican Modification of the Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI). Results: Reactivity against galectin-8 was detected in 30% of SLE patients, compared to 7% of controls (p=0.003). We could not detect any particular SLE manifestation associated to the presence of these autoantibodies. Conclusions: This is the first description of autoantibodies against galectin-8. Its higher frequency in patients with SLE suggests a pathogenic role. Further studies are needed to determine their clinical relevance
author	Pardo,Evelyn Cárcamo,Claudia Massardo,Loreto Mezzano,Verónica Jacobelli,Sergio González,Alfonso Soza G,Andrea
author_facet	Pardo,Evelyn Cárcamo,Claudia Massardo,Loreto Mezzano,Verónica Jacobelli,Sergio González,Alfonso Soza G,Andrea
author_sort	Pardo,Evelyn
title	Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico
title_short	Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico
title_full	Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico
title_fullStr	Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico
title_full_unstemmed	Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico
title_sort	autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200004
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Autoanticuerpos anti-galectina-8 en pacientes con lupus eritematoso sistémico

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