Complicaciones asociadas a la trombocitopenia profunda en pacientes con dengue
Background: Thrombocytopenia is a distinctive characteristic of dengue; however, few studies have related thrombocytopenia with its clinical severity. Aim: To identify the complications of dengue, associated to severe thrombocytopenia, defined as a platelets count below 50,000/mm³). Patients and Met...
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Sociedad Médica de Santiago
2006
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oai:scielo:S0034-988720060002000052006-03-17Complicaciones asociadas a la trombocitopenia profunda en pacientes con dengueDíaz-Quijano,Fredi AlexanderVillar-Centeno,Luis AngelMartínez-Vega,Ruth Aralí Dengue hemorrhagic fever Purpura, thrombocytopenic Thrombocytopenia Background: Thrombocytopenia is a distinctive characteristic of dengue; however, few studies have related thrombocytopenia with its clinical severity. Aim: To identify the complications of dengue, associated to severe thrombocytopenia, defined as a platelets count below 50,000/mm³). Patients and Methods: Patients with clinical and serologic (positive IgM) diagnosis of dengue, consulting at hospitals located in Santander, Colombia, during the period 1993-1998, were studied. Clinical findings and laboratory tests (including hematocrit and platelets counts) were registered. The association between severe thrombocytopenia and the presence of complications, such as hemorrhagic manifestations (positive tourniquet test, petechiae, ecchymoses, bleeding from gums, epistaxis, hematemesis, hematuria and metrorrhagia) and signs of plasma leakage (pleural effusions and haemoconcentration), were evaluated using a univariate and multivariate analysis. Results: Of the 790 patients enrolled, 502 had a platelet count below 50,000/mm³. Severe thrombocytopenia was associated with hemorrhagic manifestations (OR= 3.16; 95% CI: 2.09-4.76; p <0.0001) and signs of plasma leakage (OR= 2.67; 95% CI: 1.86-3.84; p <0.0001). The associations between severe thrombocytopenia and the complications of dengue (with exception of bleeding from gums, hematuria and metrorrhagia), were confirmed with the multivariated analysis (p <0.05). Conclusion: There was a strong association between deep thrombocytopenia and the severity of dengueinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.2 20062006-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200005es10.4067/S0034-98872006000200005 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Dengue hemorrhagic fever Purpura, thrombocytopenic Thrombocytopenia |
| spellingShingle |
Dengue hemorrhagic fever Purpura, thrombocytopenic Thrombocytopenia Díaz-Quijano,Fredi Alexander Villar-Centeno,Luis Angel Martínez-Vega,Ruth Aralí Complicaciones asociadas a la trombocitopenia profunda en pacientes con dengue |
| description |
Background: Thrombocytopenia is a distinctive characteristic of dengue; however, few studies have related thrombocytopenia with its clinical severity. Aim: To identify the complications of dengue, associated to severe thrombocytopenia, defined as a platelets count below 50,000/mm³). Patients and Methods: Patients with clinical and serologic (positive IgM) diagnosis of dengue, consulting at hospitals located in Santander, Colombia, during the period 1993-1998, were studied. Clinical findings and laboratory tests (including hematocrit and platelets counts) were registered. The association between severe thrombocytopenia and the presence of complications, such as hemorrhagic manifestations (positive tourniquet test, petechiae, ecchymoses, bleeding from gums, epistaxis, hematemesis, hematuria and metrorrhagia) and signs of plasma leakage (pleural effusions and haemoconcentration), were evaluated using a univariate and multivariate analysis. Results: Of the 790 patients enrolled, 502 had a platelet count below 50,000/mm³. Severe thrombocytopenia was associated with hemorrhagic manifestations (OR= 3.16; 95% CI: 2.09-4.76; p <0.0001) and signs of plasma leakage (OR= 2.67; 95% CI: 1.86-3.84; p <0.0001). The associations between severe thrombocytopenia and the complications of dengue (with exception of bleeding from gums, hematuria and metrorrhagia), were confirmed with the multivariated analysis (p <0.05). Conclusion: There was a strong association between deep thrombocytopenia and the severity of dengue |
| author |
Díaz-Quijano,Fredi Alexander Villar-Centeno,Luis Angel Martínez-Vega,Ruth Aralí |
| author_facet |
Díaz-Quijano,Fredi Alexander Villar-Centeno,Luis Angel Martínez-Vega,Ruth Aralí |
| author_sort |
Díaz-Quijano,Fredi Alexander |
| title |
Complicaciones asociadas a la trombocitopenia profunda en pacientes con dengue |
| title_short |
Complicaciones asociadas a la trombocitopenia profunda en pacientes con dengue |
| title_full |
Complicaciones asociadas a la trombocitopenia profunda en pacientes con dengue |
| title_fullStr |
Complicaciones asociadas a la trombocitopenia profunda en pacientes con dengue |
| title_full_unstemmed |
Complicaciones asociadas a la trombocitopenia profunda en pacientes con dengue |
| title_sort |
complicaciones asociadas a la trombocitopenia profunda en pacientes con dengue |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2006 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200005 |
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| _version_ |
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