Síndrome miasteniforme de Lambert-Eaton idiopático: Report of one case

Lambert-Eaton myasthenic syndrome (LEMS) is an autoinmune idiopathic or paraneoplastic syndrome producing antibodies agaisnt presynaptic voltage calcium channels. The clinical features of patients with LEMS are muscle weakness and autonomic dysfunction. We report a 40 years old man with a four years...

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Autores principales: Guevara O,Carlos, Pedraza C,Luis, Idiáquez C,Juan, Delgado M,Marcela
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2006
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200013
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spelling oai:scielo:S0034-988720060002000132006-03-17Síndrome miasteniforme de Lambert-Eaton idiopático: Report of one caseGuevara O,CarlosPedraza C,LuisIdiáquez C,JuanDelgado M,Marcela Lambert-Eaton Myasthenic syndrome Lambert-Eaton myasthenic syndrome (LEMS) is an autoinmune idiopathic or paraneoplastic syndrome producing antibodies agaisnt presynaptic voltage calcium channels. The clinical features of patients with LEMS are muscle weakness and autonomic dysfunction. We report a 40 years old man with a four years history of proximal weakness, absent tendon reflexes and dry mouth. The diagnosis was confirmed by characteristic electromyographic findings, showing a low-amplitude muscle response that increased dramatically after activation. Circulating antibodies to voltage-gated calcium channel were present. The search for malignant tumors was negative. The patient was treated with prednisone and azathioprine and after four months, he was able to walk and signs of autonomic dysfunction started to subsideinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.2 20062006-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200013es10.4067/S0034-98872006000200013
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Lambert-Eaton
Myasthenic syndrome
spellingShingle Lambert-Eaton
Myasthenic syndrome
Guevara O,Carlos
Pedraza C,Luis
Idiáquez C,Juan
Delgado M,Marcela
Síndrome miasteniforme de Lambert-Eaton idiopático: Report of one case
description Lambert-Eaton myasthenic syndrome (LEMS) is an autoinmune idiopathic or paraneoplastic syndrome producing antibodies agaisnt presynaptic voltage calcium channels. The clinical features of patients with LEMS are muscle weakness and autonomic dysfunction. We report a 40 years old man with a four years history of proximal weakness, absent tendon reflexes and dry mouth. The diagnosis was confirmed by characteristic electromyographic findings, showing a low-amplitude muscle response that increased dramatically after activation. Circulating antibodies to voltage-gated calcium channel were present. The search for malignant tumors was negative. The patient was treated with prednisone and azathioprine and after four months, he was able to walk and signs of autonomic dysfunction started to subside
author Guevara O,Carlos
Pedraza C,Luis
Idiáquez C,Juan
Delgado M,Marcela
author_facet Guevara O,Carlos
Pedraza C,Luis
Idiáquez C,Juan
Delgado M,Marcela
author_sort Guevara O,Carlos
title Síndrome miasteniforme de Lambert-Eaton idiopático: Report of one case
title_short Síndrome miasteniforme de Lambert-Eaton idiopático: Report of one case
title_full Síndrome miasteniforme de Lambert-Eaton idiopático: Report of one case
title_fullStr Síndrome miasteniforme de Lambert-Eaton idiopático: Report of one case
title_full_unstemmed Síndrome miasteniforme de Lambert-Eaton idiopático: Report of one case
title_sort síndrome miasteniforme de lambert-eaton idiopático: report of one case
publisher Sociedad Médica de Santiago
publishDate 2006
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200013
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AT idiaquezcjuan sindromemiasteniformedelamberteatonidiopaticoreportofonecase
AT delgadommarcela sindromemiasteniformedelamberteatonidiopaticoreportofonecase
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