Análogos de insulina: en búsqueda del reemplazo fisiológico

Insulin analogues, developed by molecular engineering, have structural changes in the A and B insulin chains. These modifications change their action profile, rendering insulin replacement closer to physiology. Rapid acting analogues like lispro, aspart and glulisine, are absorbed rapidly from the s...

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Autores principales:	Eyzaguirre C,Francisca, Codner,Ethel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Diabetes mellitus, insulin dependent Insulin Insulin, long acting Pro insulin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200016
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spelling	oai:scielo:S0034-988720060002000162006-03-17Análogos de insulina: en búsqueda del reemplazo fisiológicoEyzaguirre C,FranciscaCodner,Ethel Diabetes mellitus, insulin dependent Insulin Insulin, long acting Pro insulin Insulin analogues, developed by molecular engineering, have structural changes in the A and B insulin chains. These modifications change their action profile, rendering insulin replacement closer to physiology. Rapid acting analogues like lispro, aspart and glulisine, are absorbed rapidly from the subcutaneous tissue to the circulation. In addition, two long acting insulin analogues have been developed: glargine and detemir. The combination of a long acting insulin, to maintain baseline levels, and multiple daily doses of a rapid acting analogue are the mainstay of basal-bolus therapy. Multiples studies have compared human insulin (NPH and regular) with insulin analogues in patients with type 1 or 2 diabetes mellitus, showing an improvement in the metabolic control, fewer hypoglycemic events and better quality of life. In summary, insulin analogues offer new therapeutic options and allow an individualized intensive treatmentinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.2 20062006-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200016es10.4067/S0034-98872006000200016
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes mellitus, insulin dependent Insulin Insulin, long acting Pro insulin
spellingShingle	Diabetes mellitus, insulin dependent Insulin Insulin, long acting Pro insulin Eyzaguirre C,Francisca Codner,Ethel Análogos de insulina: en búsqueda del reemplazo fisiológico
description	Insulin analogues, developed by molecular engineering, have structural changes in the A and B insulin chains. These modifications change their action profile, rendering insulin replacement closer to physiology. Rapid acting analogues like lispro, aspart and glulisine, are absorbed rapidly from the subcutaneous tissue to the circulation. In addition, two long acting insulin analogues have been developed: glargine and detemir. The combination of a long acting insulin, to maintain baseline levels, and multiple daily doses of a rapid acting analogue are the mainstay of basal-bolus therapy. Multiples studies have compared human insulin (NPH and regular) with insulin analogues in patients with type 1 or 2 diabetes mellitus, showing an improvement in the metabolic control, fewer hypoglycemic events and better quality of life. In summary, insulin analogues offer new therapeutic options and allow an individualized intensive treatment
author	Eyzaguirre C,Francisca Codner,Ethel
author_facet	Eyzaguirre C,Francisca Codner,Ethel
author_sort	Eyzaguirre C,Francisca
title	Análogos de insulina: en búsqueda del reemplazo fisiológico
title_short	Análogos de insulina: en búsqueda del reemplazo fisiológico
title_full	Análogos de insulina: en búsqueda del reemplazo fisiológico
title_fullStr	Análogos de insulina: en búsqueda del reemplazo fisiológico
title_full_unstemmed	Análogos de insulina: en búsqueda del reemplazo fisiológico
title_sort	análogos de insulina: en búsqueda del reemplazo fisiológico
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000200016
work_keys_str_mv	AT eyzaguirrecfrancisca analogosdeinsulinaenbusquedadelreemplazofisiologico AT codnerethel analogosdeinsulinaenbusquedadelreemplazofisiologico
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Análogos de insulina: en búsqueda del reemplazo fisiológico

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