Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis

Background: Endometrioid carcinoma and clear cell carcinoma of the ovary are associated to endometriosis. Somatic mutations of PTEN (10q23.3) are present in endometrial endometrioid carcinoma. Therefore, these mutations could be also present in ovarian tumors. Molecular studies show that solitary en...

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Autores principales:	Castiblanco G,Adriana, Pires N,Yumay, Wistuba O,Ignacio, Riquelme S,Erick, Andrade M,Leonardo, Corvalán R,Alejandro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Endometrial neoplasms Endometriosis Ovarian neoplasms PTEN protein human
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000300001
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spelling	oai:scielo:S0034-988720060003000012006-05-02Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosisCastiblanco G,AdrianaPires N,YumayWistuba O,IgnacioRiquelme S,ErickAndrade M,LeonardoCorvalán R,Alejandro Endometrial neoplasms Endometriosis Ovarian neoplasms PTEN protein human Background: Endometrioid carcinoma and clear cell carcinoma of the ovary are associated to endometriosis. Somatic mutations of PTEN (10q23.3) are present in endometrial endometrioid carcinoma. Therefore, these mutations could be also present in ovarian tumors. Molecular studies show that solitary endometriotic cysts are monoclonal, have aneuploid DNA, have a loss of 9p,11q and 22q heterozygosity (LOH) and a higher cellular proliferation index of the epithelial component. Aim: To determine the cellular proliferation index using Ki 67, the immunohistochemical expression of PTEN and LOH in patients with ovarian endometriosis without atypia (EN), ovarian endometriosis with atypia (EA) and endometriosis with adjacent ovarian carcinoma (ET). Material and methods: Paraffin embedded samples of 37 endometrioid and clear cell carcinomas of the ovary (CC/CE), 15 solitary ovarian EN and 15 ovarian EA, were studied. Expression of Ki 67 and PTEN was measured by immunohistochemistry. LOH of 10q23.3 locus was measured by polymerase chain reaction. Results: Ki 67 was 5.5 and 2.3% in EA and EN, respectively (p <0.005). There was a histological correlation between EA and a higher cellular proliferation index. PTEN was negative in 5 of 15 EN, 9 of 15 EA and 30 of 37 CE/CC. There was a correlation between LOH and loss of PTEN protein in EN, EA and ET (60%). Conclusions: Negative expression on PTEN in EN; EA; ET and CE/CC is a manifestation of the inactivation of this gene. The mechanisms that cause this inactivation, must be elucidatedinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.3 20062006-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000300001es10.4067/S0034-98872006000300001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Endometrial neoplasms Endometriosis Ovarian neoplasms PTEN protein human
spellingShingle	Endometrial neoplasms Endometriosis Ovarian neoplasms PTEN protein human Castiblanco G,Adriana Pires N,Yumay Wistuba O,Ignacio Riquelme S,Erick Andrade M,Leonardo Corvalán R,Alejandro Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis
description	Background: Endometrioid carcinoma and clear cell carcinoma of the ovary are associated to endometriosis. Somatic mutations of PTEN (10q23.3) are present in endometrial endometrioid carcinoma. Therefore, these mutations could be also present in ovarian tumors. Molecular studies show that solitary endometriotic cysts are monoclonal, have aneuploid DNA, have a loss of 9p,11q and 22q heterozygosity (LOH) and a higher cellular proliferation index of the epithelial component. Aim: To determine the cellular proliferation index using Ki 67, the immunohistochemical expression of PTEN and LOH in patients with ovarian endometriosis without atypia (EN), ovarian endometriosis with atypia (EA) and endometriosis with adjacent ovarian carcinoma (ET). Material and methods: Paraffin embedded samples of 37 endometrioid and clear cell carcinomas of the ovary (CC/CE), 15 solitary ovarian EN and 15 ovarian EA, were studied. Expression of Ki 67 and PTEN was measured by immunohistochemistry. LOH of 10q23.3 locus was measured by polymerase chain reaction. Results: Ki 67 was 5.5 and 2.3% in EA and EN, respectively (p <0.005). There was a histological correlation between EA and a higher cellular proliferation index. PTEN was negative in 5 of 15 EN, 9 of 15 EA and 30 of 37 CE/CC. There was a correlation between LOH and loss of PTEN protein in EN, EA and ET (60%). Conclusions: Negative expression on PTEN in EN; EA; ET and CE/CC is a manifestation of the inactivation of this gene. The mechanisms that cause this inactivation, must be elucidated
author	Castiblanco G,Adriana Pires N,Yumay Wistuba O,Ignacio Riquelme S,Erick Andrade M,Leonardo Corvalán R,Alejandro
author_facet	Castiblanco G,Adriana Pires N,Yumay Wistuba O,Ignacio Riquelme S,Erick Andrade M,Leonardo Corvalán R,Alejandro
author_sort	Castiblanco G,Adriana
title	Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis
title_short	Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis
title_full	Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis
title_fullStr	Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis
title_full_unstemmed	Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis
title_sort	rol patogénico del gen supresor de tumores pten en cáncer ovárico asociado a endometriosis
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000300001
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Rol patogénico del gen supresor de tumores PTEN en cáncer ovárico asociado a endometriosis

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