Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad

Background: Zinc is important for insulin synthesis, storage and secretion. When zinc concentration decrease, there is a concomitant reduction in insulin secretion and peripheral insulin sensitivity Aim: To assess the effects of zinc sulfate on insulin sensitivity, leptin and androgens in obese indi...

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Autores principales:	Gómez-García,Anel, Hernández-Salazar,Eduardo, González-Ortiz,Manuel, Martínez-Abundis,Esperanza
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Hyperinsulinism Insulin Leptin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000300002
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spelling	oai:scielo:S0034-988720060003000022006-05-02Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidadGómez-García,AnelHernández-Salazar,EduardoGonzález-Ortiz,ManuelMartínez-Abundis,Esperanza Hyperinsulinism Insulin Leptin Background: Zinc is important for insulin synthesis, storage and secretion. When zinc concentration decrease, there is a concomitant reduction in insulin secretion and peripheral insulin sensitivity Aim: To assess the effects of zinc sulfate on insulin sensitivity, leptin and androgens in obese individuals. Material and methods: A randomized, double-blind, placebo-controlled clinical trial was performed in 14 obese volunteers between 21 and 30 years old, with body mass index (BMI) ³ 27 kg/m2. During one month, seven subjects received 100 mg/day of zinc sulfate orally (ZnG) and the other seven received placebo, as control group (CG). At baseline and after the intervention, insulin sensitivity was measured using a euglycemic-hyperinsulinemic clamp technique. Blood glucose, serum lipids, zinc, androgens and leptin were also measured in a fasting blood sample. Results: After the intervention, a rise in zinc concentrations from 11.8 to 16.9 umol/L; p=0.001 and in leptin levels from 15.2 to 27.7 ng/mL; p=0.029, was observed in the ZnG. No changes were observed in the CG. There were no significant changes in insulin sensitivity and androgens after the intervention with zinc sulfate. Conclusions: Zinc increased the leptin concentrations in obese individuals, but did not modify insulin sensitivity and androgensinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.3 20062006-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000300002es10.4067/S0034-98872006000300002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hyperinsulinism Insulin Leptin
spellingShingle	Hyperinsulinism Insulin Leptin Gómez-García,Anel Hernández-Salazar,Eduardo González-Ortiz,Manuel Martínez-Abundis,Esperanza Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad
description	Background: Zinc is important for insulin synthesis, storage and secretion. When zinc concentration decrease, there is a concomitant reduction in insulin secretion and peripheral insulin sensitivity Aim: To assess the effects of zinc sulfate on insulin sensitivity, leptin and androgens in obese individuals. Material and methods: A randomized, double-blind, placebo-controlled clinical trial was performed in 14 obese volunteers between 21 and 30 years old, with body mass index (BMI) ³ 27 kg/m2. During one month, seven subjects received 100 mg/day of zinc sulfate orally (ZnG) and the other seven received placebo, as control group (CG). At baseline and after the intervention, insulin sensitivity was measured using a euglycemic-hyperinsulinemic clamp technique. Blood glucose, serum lipids, zinc, androgens and leptin were also measured in a fasting blood sample. Results: After the intervention, a rise in zinc concentrations from 11.8 to 16.9 umol/L; p=0.001 and in leptin levels from 15.2 to 27.7 ng/mL; p=0.029, was observed in the ZnG. No changes were observed in the CG. There were no significant changes in insulin sensitivity and androgens after the intervention with zinc sulfate. Conclusions: Zinc increased the leptin concentrations in obese individuals, but did not modify insulin sensitivity and androgens
author	Gómez-García,Anel Hernández-Salazar,Eduardo González-Ortiz,Manuel Martínez-Abundis,Esperanza
author_facet	Gómez-García,Anel Hernández-Salazar,Eduardo González-Ortiz,Manuel Martínez-Abundis,Esperanza
author_sort	Gómez-García,Anel
title	Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad
title_short	Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad
title_full	Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad
title_fullStr	Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad
title_full_unstemmed	Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad
title_sort	efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000300002
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Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad

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